In Vitro Drug Sensitivity-Gene Expression Correlations Involve a Tissue of Origin Dependency

Abstract

A major concern of chemogenomics is to associate drug activity with biological variables. Several reports have clustered cell line drug activity profiles as well as drug activity-gene expression correlation profiles and noted that the resulting groupings differ but still reflect mechanism of action. The present paper shows that these discrepancies can be viewed as a weighting of drug−drug distances, the weights depending on which cell lines the two drugs differ in.