In vitro evaluation and comparison of antioxidant activities of various extracts of leaves and stems of Kalanchoe pinnatum

Kamboj, Anjoo; Saluja, AjayKumar; Jain, UpendraK; Bhatti, Manisha

doi:10.4103/0973-8258.108255

Cited by 14 publications

(4 citation statements)

References 10 publications

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“…Furthermore, the absorbance was found to be increased with the dose increase which indicates the increase in reducing power. Bhatti et al (2012) also have done similar studies for K. Pinnata extracts of leaves and stems by both PM and FRAP assays and confirmed that scavenging capacity increases with increase in concentration, which supports our findings [24].…”

Section: Discussionsupporting

confidence: 91%

Antioxidant Activity Evaluation of Kalanchoe Pinnata (Lam.) Pers. Fresh Leaf Juice

Bhavsar

Chandel²

2022

Asian J Pharm Clin Res

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Objective: The objective of this study was to determine the antioxidant and free radical scavenging properties of Kalanchoe pinnata (Lam.) Pers. fresh leaf juice for standardized doses using different types of assays. Methods: The investigation of the antioxidant activity was carried out for the previously standardized doses (by cytotoxicity and genotoxicity analysis) – 50 μl (low dose - LD) and 70 μl (high dose-HD) by Phosphomolybdenum (PM), Ferric Reducing Antioxidant Power (FRAP), 2, 2-diphenyl-1- picrylhydrazyl (DPPH) radical scavenging activity, and 2, 2’-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging activity assays. Results: The activity measured by PM assay for LD and HD of the extract was equivalent to 109 μg/ml and 141 μg/ml of ascorbic acid, respectively, while by FRAP assay, it was equivalent to 17.5 μg/ml and 47 μg/ml of ascorbic acid, respectively. The activity measured by DPPH assay was found equivalent to 83 μg/ml and 177.5 μg/ml of ascorbic acid for LD and HD, with the percent scavenging activity 4.55% and 17.04%, respectively. Similarly, the activity of LD and HD by ABTS assay was found equivalent to 277.5 μg/ml and 308 μg/ml of ascorbic acid with the percent scavenging activity 39.01% and 47.93%, respectively. Conclusion: The changes observed in the absorbance values for all the assays reflected the increasing antioxidant activity of the plant extract in dose-dependent manner, which justifies the traditional use of this herb in prevention of diseases induced by oxidative stress. The antioxidant activity of K. pinnata fresh leaf juice has been conducted for the 1st time and has not been previously reported.

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Section: Discussionsupporting

confidence: 91%

Antioxidant Activity Evaluation of Kalanchoe Pinnata (Lam.) Pers. Fresh Leaf Juice

Bhavsar

Chandel²

2022

Asian J Pharm Clin Res

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“…56 The phosphomolybdenum method is quantitative since the total antioxidant activity is expressed as the number of equivalents of ascorbic acid. Total antioxidant capacity of the extract was 248.26%.…”

Section: Resultsmentioning

confidence: 99%

Chemical Profile and Antioxidant Properties of Mundulea sericea

Khyade¹,

Waman²

2017

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Objectives: To evaluate the phytochemical composition and the antioxidant activity of aqueous-methanolic (20:80) leaves extract of Mundulea sericea Willd. Methods: The extract of leaves was tested for antioxidant activity using various in vitro models viz., 2,2-diphenyl-1-picrylhydrazyl (DPPH), nitric oxide, ABTS, ferric reducing antioxidant power (FRAP), total antioxidant activity and reducing power. The phytochemical composition (GC-MS and HPLC) along with total phenolic and flavonoid content of the extract at different concentrations were also determined. Results: Total phenolic and flavonoid contents were found to be equivalents to 107.86 ± 0.53 µg of gallic acid and 44.53 ± 0.156 µg of rutin /mg of dried hydro-methanolic methanolic extract, respectively. Among various antioxidant assays performed, maximum inhibition was observed for ABTS (IC 50 13.26 ± 0.396 μg) followed by DPPH (IC 50 79.83 ± 0.306 μg) and NO (IC 50 6.35 ± 0.23 μg/mL) assay. The GC-MS analysis revealed over 38 compounds; the prevailing compounds were Sec-Butyl ethyl sulfoxide and Di-methyl sulfoxonium formyl methylide. The RP-HPLC analysis further confirmed the presence of rutin, cinnamic acid and salicylic acid. Conclusion:The results of the present study demonstrated that Mundulea sericea leaves possess high phenolic with flavonoid contents and also revealed potential antioxidant activity so these leaves could be used as a viable source of natural antioxidants for industrial and pharmaceutical preparations.

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“…The leaves were reported to show maximum scavenging effects than stems and the ethanolic extract showed more total phenolic and flavonoid content than other extracts. The high amount of phenols and flavonoids in the extracts may be the reason for their high antioxidative activity (Bhatti et al, 2012). The phenolic constituents have the ability to interact with the transition metals even in lipid phase and chelate them by filling their aqua-coordination sites and generating metal-coordinated insoluble complexes.…”

Section: Antioxidant Activitymentioning

confidence: 99%

“…Inhibition of lipid auto-oxidation could be attributed to the ability of phenolics to stabilise the radicals through generation of stabilised phenoxyl radicals by directly scavenging peroxyl radicals. 29…”

Section: Antioxidant Activitymentioning

confidence: 99%

A review on kalanchoe pinnata (Crassulaceae)

Singh

Singh²,

Singh³

2021

IJPP

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The primary goal of this study is to offer preliminary data for drug discovery research using Kalanchoe pinnata a heavenly plant that has a broad variety of active chemicals, including alkaloids, Phenols, Phenylpropanoids, Flavanoids, Triterpenoids, steroids, organic Salts. This plant was discovered to have a variety of pharmacological properties, including Antihypertensiveactivity, Hepatoprotective activity, Antimutagenic activity, Anti-ulcer activity, Uterine Contractility, Antidiabetic activity, Wound-healing activity, Antioxidant activity, Antitumour activity, Antiviral activity, Antimicrobial activity, Antileishmanial activity, Insecticidal activity, Antipyreticactivity, Antilithiatic activity, Neuropharmacological Immunosuppressive antibacterial activity, Cytotoxicity of testis. This study provides phytoconstituents and pharmacological activity of K. pinnata, a medicinal plant that may help researchers conduct more advanced qualitative research.

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In vitro evaluation and comparison of antioxidant activities of various extracts of leaves and stems of Kalanchoe pinnatum

Cited by 14 publications

References 10 publications

Antioxidant Activity Evaluation of Kalanchoe Pinnata (Lam.) Pers. Fresh Leaf Juice

Antioxidant Activity Evaluation of Kalanchoe Pinnata (Lam.) Pers. Fresh Leaf Juice

Chemical Profile and Antioxidant Properties of Mundulea sericea

A review on kalanchoe pinnata (Crassulaceae)

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