In vitro evaluation of a spacer in a pediatric model of mechanical ventilation

Boukhettala, Nabile; Diot, Patrice; Porée, Thierry; Vecellio, Laurent

doi:10.1183/13993003.congress-2015.pa1868

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“…During invasive mechanical ventilation with a 2-limb circuit, the large spacer has been shown to deliver a larger inhaled dose than the T-piece for aerosol delivery from vibrating mesh nebulizers. 6,8,9 However, those findings may not be relevant to use in a single-limb circuit with a noninvasive ventilator, in which higher continuous gas flow passes through a fixed orifice resistor. In addition, the patient interface (mask vs endotracheal tube) and placement of the aerosol generator differ with noninvasive ventilation (NIV) compared with conventional invasive ventilation.…”

Section: Introductionmentioning

confidence: 99%

Performance of Large Spacer Versus Nebulizer T-Piece in Single-Limb Noninvasive Ventilation

et al. 2018

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The T-piece and large spacer were equally efficient for salbutamol delivery from the mesh nebulizer in patients with COPD and on single-limb noninvasive ventilation. Adding a preliminary bronchodilator dose by pMDI prenebulization showed a trend toward greater pulmonary bioavailability of nebulized salbutamol and may be worth considering to maximize delivery of salbutamol to patients who are severely ill.

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Section: Introductionmentioning

confidence: 99%