In vitro evaluation of calcium binding capacity of chitosan and thiolated chitosan poly(isobutyl cyanoacrylate) core–shell nanoparticles

Bravo‐Osuna, Irene; Millotti, Gioconda; Vauthier, Christine; Ponchel, Gilles

doi:10.1016/j.ijpharm.2007.01.039

Cited by 64 publications

(38 citation statements)

References 29 publications

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“…Recently Bravo-Osuna and co-workers have proposed several approaches to elaborate the application of thiolated CS by preserving its mucoadhesive property and permeation-enhancing ability. They have utilised the emulsion polymerization method to prepare thiolated CS-NPs coated with poly-isobutylcyanoacrylate (110)(111)(112)(113). They evaluated the impact of different formulation factors like the effect of molecular weight and CS-thiobarbituric acid ratio for surface modification.…”

Section: Thiolated Chitosanmentioning

confidence: 99%

“…It can be said that these orally administered CS-NPs are still in their early stage of pre-clinical evaluation and would require further investigation before being considered for evaluation in humans. So far, most of the results obtained are based on in vitro (49,52,110,(132)(133)(134)(135) and ex vivo (74,77,78) studies. Although some pre-clinical studies for CS-NPs (oral, parenteral etc.)…”

Section: Current Perspective Of Chitosan Nanoparticles For Clinical Usementioning

confidence: 99%

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Recent Advancement of Chitosan-Based Nanoparticles for Oral Controlled Delivery of Insulin and Other Therapeutic Agents

2010

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Abstract. Nanoparticles composed of naturally occurring biodegradable polymers have emerged as potential carriers of various therapeutic agents for controlled drug delivery through the oral route. Chitosan, a cationic polysaccharide, is one of such biodegradable polymers, which has been extensively exploited for the preparation of nanoparticles for oral controlled delivery of several therapeutic agents. In recent years, the area of focus has shifted from chitosan to chitosan derivatized polymers for the preparation of oral nanoparticles due to its vastly improved properties, such as better drug retention capability, improved permeation, enhanced mucoadhesion and sustained release of therapeutic agents. Chitosan derivatized polymers are primarily the quaternized chitosan derivatives, chitosan cyclodextrin complexes, thiolated chitosan, pegylated chitosan and chitosan combined with other peptides. The current review focuses on the recent advancements in the field of oral controlled release via chitosan nanoparticles and discusses about its in vitro and in vivo implications.

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Section: Thiolated Chitosanmentioning

confidence: 99%

Section: Current Perspective Of Chitosan Nanoparticles For Clinical Usementioning

confidence: 99%

Recent Advancement of Chitosan-Based Nanoparticles for Oral Controlled Delivery of Insulin and Other Therapeutic Agents

2010

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“…Many nonspecific enzymes, namely, cellulases, lipases and proteases, or specific enzymes chitosanases, have been used to prepare COS (Thadathil and Velappan 2014). The 10 kDa or less COS have been found lots of biological activities owe to their structures and physicochemical properties (Xia et al, 2011), such as hypocholesterolemic (Kim and Rajapakse, 2005), antimicrobial Kim, 2000, 2001), immunity-enhancing and anticancer effects (Xia et al, 2011), accelerating calcium and iron absorption (Bravo-Osuna et al, 2007), antioxidant (Je et al, 2004;Mendis et al, 2007;Fang et al, 2013) and so on. However, relatively little is known about the effects and mechanism of COS on the vase life of cut roses.…”

Section: Introductionmentioning

confidence: 99%

Chitooligosaccharide Prolongs Vase Life of Cut Roses by Decreasing Reactive Oxygen Species

Jing

HuanQing²

2015

HST

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Chitooligosaccharide (COS), as antioxidant, extensively applied to food and juice preservation. In the present study, influences of COS on vase life and ornamental value of cut roses were investigated. Results showed that vase life of cut roses treated by COS was longer 6.4 days than one of control and ornamental character of cut roses was improved effectively by COS. The increase of vase life and ornamental value were chiefly governed by that COS improved water absorption capacity of cut roses. Besides that, COS decreased the contents of superoxide anion and hydrogen peroxide and lowered the levels of malondialdehyde in turn during the senescence process of cut roses. That was because that COS not only enhanced activities of antioxidant enzymes glutathione reductase, but also improved reduced glutathione contents in petals of cut rose. Therefore, COS could be used in commercial preservatives to improve the longevity of cut roses.

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“…In recent years, numerous studies have been carried out to investigate the synthesis and the application of polysaccharide-based self-aggregate nanoparticles as drug delivery systems. Generally, these hydrophobic molecules can be divided into linear [184,185], cyclic hydrophobic molecules [186,187], polyacrylate family [188,189], etc.…”

Section: Self-assembly Polysaccharide Nanoparticlesmentioning

confidence: 99%

Novel nanoparticle materials for drug/food delivery-polysaccharides

Chen

Liu

Wong

2016

Physical Sciences Reviews

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In vitro evaluation of calcium binding capacity of chitosan and thiolated chitosan poly(isobutyl cyanoacrylate) core–shell nanoparticles

Cited by 64 publications

References 29 publications

Recent Advancement of Chitosan-Based Nanoparticles for Oral Controlled Delivery of Insulin and Other Therapeutic Agents

Recent Advancement of Chitosan-Based Nanoparticles for Oral Controlled Delivery of Insulin and Other Therapeutic Agents

Chitooligosaccharide Prolongs Vase Life of Cut Roses by Decreasing Reactive Oxygen Species

Novel nanoparticle materials for drug/food delivery-polysaccharides

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