In Vitro Fertilization and Early Pregnancy Outcomes After Coronavirus Disease 2019 (COVID-19) Vaccination

Aharon, Devora; Lederman, M.; Ghofranian, Atoosa; Hernández-Nieto, Carlos; Canon, Chelsea M.; Hanley, William J.; Gounko, Dmitry; Lee, Joseph A.; Stein, Daniel E.; Büyük, Erkan; Copperman, A.B.

doi:10.1097/aog.0000000000004713

Cited by 63 publications

(91 citation statements)

References 20 publications

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“…A retrospective study conducted in the USA compared the pregnancy outcomes of 214 infertile patients vaccinated with BioNTech/Pfizer (BNT162b2) or Moderna (mRNA-1273) vaccines and 733 infertile patients who had not been vaccinated. The results showed no significant differences in CPR, BPR, and ongoing pregnancy rates between the two groups [ 12 ]. A study conducted in Israel analyzed the effect of patients’ immunization after COVID-19 infection or vaccination with an mRNA vaccine on FET.…”

Section: Discussionmentioning

confidence: 99%

“…Orvieto et al were the first to report the effect of mRNA vaccines on embryo quality and IVF outcomes [ 11 ]. A few studies on the effects of mRNA vaccines on embryo quality and pregnancy outcomes have been conducted in the USA and Israel [ 12 – 15 ]. To date, only one study has investigated the effect of inactivated vaccines on embryo quality and pregnancy outcomes in infertile patients treated with ART [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

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Effects of COVID-19 vaccination status, vaccine type, and vaccination interval on IVF pregnancy outcomes in infertile couples

Dong

Zhang

et al. 2022

J Assist Reprod Genet

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Purpose This study aimed to explore whether the coronavirus disease (COVID-19) vaccination of both partners in infertile couples, different types of COVID-19 vaccines, and the interval between complete vaccination and oocyte retrieval or embryo transfer (ET) affect the quality of embryos and pregnancy rates in in vitro fertilization (IVF). Methods This was a prospective cohort study, comprising 735 infertile couples conducted between December 6, 2021, and March 31, 2022, in a single university hospital-based IVF center. The patients were divided into different groups according to the vaccination status of both partners in infertile couples, type of vaccine, and interval between complete vaccination and IVF treatment. The embryo quality and pregnancy rates were compared among different groups. Results The results showed that embryo quality and pregnancy rates had no significant differences among different groups. The multivariate regression model showed that the vaccination status of both infertile couples, types of vaccines, and intervals had no significant effects on the clinical pregnancy rate. Conclusions The vaccination status of both partners in infertile couples, different types of vaccines, and time intervals have no effect on embryo quality and pregnancy rates in IVF. This is the first study to compare the vaccination status of both partners in infertile couples and the impact of different vaccine types on pregnancy rates and embryo quality in detail. Our findings provide evidence of vaccine safety for infertile couples wishing to undergo IVF treatment. This evidence is crucial for decision-making by clinicians and policymakers involved in IVF cycles.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of COVID-19 vaccination status, vaccine type, and vaccination interval on IVF pregnancy outcomes in infertile couples

Dong

Zhang

et al. 2022

J Assist Reprod Genet

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“…In our study, we found no difference in the biochemical and clinical pregnancy rate between vaccine group and control group, suggesting that the inactivated COVID-19 vaccine has no negative effect on early pregnancy outcomes after IVF. The effects of female vaccination (including mRNA and inactivated vaccines) on early pregnancy are newly reported, almost all suggesting that SARS-CoV-2 vaccination in females did not result in any measurable detrimental effects after IVF (Aharon et al, 2022;Huang et al, 2022).…”

Section: Discussionmentioning

confidence: 98%

Investigate the effect of COVID‐19 inactivated vaccine on sperm parameters and embryo quality in in vitro fertilization

Xia

Zhao

et al. 2022

Andrologia

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Since the reproductive toxicity of COVID‐19 vaccines have not been assessed in previous clinical trials, and studies have shown that SARS‐CoV‐2 is associated with a decrease in sperm parameters. Although it has been reported that the mRNA SARS‐CoV‐2 vaccines do not adversely affect semen parameters, whether this conclusion applies to inactivated vaccines remains unclear. Here, we conducted a study among patients who accepted in vitro fertilization (IVF) at the reproductive centre between June and August of 2021. In the enrolled cases, men who have completed two doses of COVID‐19 inactivated vaccine were included in “vaccine group” (N = 105), and those who were not vaccinated were included in “control group” (N = 155). In this study, we compare the sperm parameters and embryo quality between these two groups. Our data showed that the sperm parameters were similar in terms of volume, sperm concentration, sperm count, progressive motility, total motility and total motile sperm count between these two groups. Similarly, no significant differences were observed in IVF outcomes. The mean number of 2PN, cleavage‐stage embryos, blastocysts, and good‐quality blastocysts was 8.59 ± 4.47, 5.06 ± 3.17 and 2.08 ± 1.79 in vaccine group, 7.75 ± 4.14, 4.34 ± 3.06 and 1.74 ± 1.54 in control group, respectively. The high‐quality blastocyst rate was 41.05% (218 of 531) in vaccine group and 40.03% (269 of 672) in control group (p > 0.05). In addition, no differences were observed in biochemical and clinical pregnancy rates between the two groups. In summary, our results revealed that COVID‐19 inactivated vaccine administration exhibited no negative effect on sperm parameters and embryo quality in IVF.

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“…Virus in vaginal fluid or semen could potentially infect a newly conceived embryo prior to implantation, potentially compromising establishment or maintenance of the pregnancy. In view of this, our data highlights the need for expectant mothers or couples considering pregnancy to fully vaccinate to help prevent SARS-CoV-2 infection that could jeopardize their health and their pregnancy [48–50].…”

Section: Discussionmentioning

confidence: 99%

SARS-CoV-2 Can Infect Human Embryos

Montaño

Victor

Griffin

et al. 2021

Preprint

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Vertical transmission of SARS-CoV-2, the virus responsible for COVID-19, from parents to early embryos during conception could be catastrophic, but is contingent on the susceptibility of cells of the embryo to infection. Because presence of the SARS-CoV-2 virus has been reported in the human reproductive system, we assessed whether pre-implantation embryos are permissive to SARS-CoV-2 entry. RNA-seq and immunostaining studies revealed presence of two key entry factors in the trophectoderm of blastocyst-stage embryos, the ACE2 receptor and the TMPRSS2 protease. Exposure of blastocysts to fluorescent reporter virions pseudotyped with the SARS-CoV-2 Spike (S) glycoprotein revealed S-ACE2 dependent entry and fusion. These results indicate that human pre-implantation embryos can be infected by SARS-CoV-2, a finding pertinent to natural human conceptions and assisted reproductive technologies during and after the COVID-19 pandemic.

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In Vitro Fertilization and Early Pregnancy Outcomes After Coronavirus Disease 2019 (COVID-19) Vaccination

Cited by 63 publications

References 20 publications

Effects of COVID-19 vaccination status, vaccine type, and vaccination interval on IVF pregnancy outcomes in infertile couples

Effects of COVID-19 vaccination status, vaccine type, and vaccination interval on IVF pregnancy outcomes in infertile couples

Investigate the effect of COVID‐19 inactivated vaccine on sperm parameters and embryo quality in in vitro fertilization

SARS-CoV-2 Can Infect Human Embryos

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