In vitro human intestinal microbiota biotransformation of nobiletin using liquid chromatography–mass spectrometry analysis and background subtraction strategy

Lan, Hong-Ci; Li, Shang-Zhen; Li, Kai; Liu, E‐Hu

doi:10.1002/jssc.202001150

Cited by 12 publications

(4 citation statements)

References 24 publications

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“…However, there are few effective drugs for ENS damage. The intestinal microbiota can cause nobiletin demethylation [ 29 ]. After demethylation, nobiletin has a stronger solubility and biological activity [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

“…There are three main pathways for the entry of nobiletin into the body: oral administration, intravenous injection and intraperitoneal injection. After oral administration, nobiletin is metabolized by intestinal microbiota into more active products [ 29 , 79 ]. The intestinal microbiota of healthy individuals can cause demethylation of nobiletin [ 7 , 29 ].…”

Section: Absorption and Distribution Patterns Of Nobiletinmentioning

confidence: 99%

“…After oral administration, nobiletin is metabolized by intestinal microbiota into more active products [ 29 , 79 ]. The intestinal microbiota of healthy individuals can cause demethylation of nobiletin [ 7 , 29 ]. After demethylation, flavonoids with stronger solubility and biological activity can be produced [ 7 , 14 ].…”

Section: Absorption and Distribution Patterns Of Nobiletinmentioning

confidence: 99%

See 2 more Smart Citations

A review on recent advances on nobiletin in central and peripheral nervous system diseases

Pang,

Xiong,

et al. 2023

Eur J Med Res

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In recent years, the role of nobiletin in neuronal disorders has received extensive attention. However, the study of nobiletin in the peripheral nervous system is limited. Nobiletin, as a compound with high fat solubility, high bioavailability and low toxicity, has been extensively studied. Accumulating scientific evidence has shown that nobiletin has a variety of biological functions in the nervous system, such as inhibiting the expression of inflammatory factors, reducing the neurotoxic response, improving the antioxidant capacity, promoting the survival of nerve cells, promoting axon growth, reducing blood‒brain barrier permeability, reducing brain oedema, promoting cAMP response element binding protein expression, improving memory, and promoting mild depolarization of nerve cell mitochondria to improve antioxidative stress capacity. Accumulating studies have shown that nobiletin also protects enteric nervous system, spinal cord and sciatic nerve. To explore the new therapeutic potential of nobiletin in the nervous system, recent and relevant research progress is reviewed in this article. This will provide a new research idea for nobiletin in the nervous system.

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Section: Discussionmentioning

confidence: 99%

Section: Absorption and Distribution Patterns Of Nobiletinmentioning

confidence: 99%

Section: Absorption and Distribution Patterns Of Nobiletinmentioning

confidence: 99%

See 1 more Smart Citation

A review on recent advances on nobiletin in central and peripheral nervous system diseases

Pang,

Xiong,

et al. 2023

Eur J Med Res

View full text Add to dashboard Cite

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“…These may be partially contributed to the fact that the concentrations and the MS fragments abundances of these identified compounds may be different in rat plasma, urine, and fecal sample [26]. Also the preferred metabolism organs (liver, gastrointestinal tract, gut microbiota) of these compounds existing in S. barbata may be different [27].…”

Section: Characterization Of the Absorbed Constituents And Metabolite...mentioning

confidence: 99%

Characterization of the chemical constituents and in vivo metabolic profile of Scutellaria barbata D. Don by ultra high performance liquid chromatography with high‐resolution mass spectrometry

Jiang

Qin

et al. 2022

J of Separation Science

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Scutellaria barbata D. Don (S. barbata) is one of the most frequently used anticancer herb medicine in China. Mechanistic understanding of the biological activities of S. barbata is hindered by limited knowledge regarding its components and metabolic profile. In this study, ultra-high-performance liquid chromatography coupled with high resolution mass spectrometry (quadrupole time-of-flight mass spectrometry) was used to identify the chemical constituents in S. barbata and their metabolic profiles in rats. By applying cleavage rules and comparison with reference substances, 89 components were identified in S. barbata, which included 45 flavonoids, 28 diterpenoids, 10 phenolics, and 6 others.A total of 110 compounds, including 32 prototype compounds and 78 metabolites, were identified or tentatively characterized in vivo. Methylation, sulfonation, and glucuronidation were the main metabolic pathways, which could be attributed to the fact that several of the compounds in S. barbata have phenolic hydroxyl groups. This is the first systematic study on the chemical constituents and in vivo metabolic profile of S. barbata. The analytical method features a quick and comprehensive dissection of the chemical composition and metabolic profile of S. barbata and provides a basis for exploring its various biological activities.

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Unveiling the potentials and action mechanisms of Citri reticulatae Pericarpium as an anti‐inflammatory food

Li,

Chen,

Zhou

et al. 2024

Food Frontiers

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Modern lifestyle has led human body under a frequent exposure of chronic inflammation. Intriguingly, extensive studies have indicated that Citri reticulatae Pericarpium (CRP), the dried peel of Citrus reticulata Blanco and its cultivated varieties, has immense potential as an anti‐inflammatory food. Therefore, the present review aims to summarize advances in utilizing CRP for the prevention and controlling of inflammation under various pathological conditions. In particular, this review provides a comprehensive overview of the bioactive compounds present in CRP, with a specific focus on polymethoxyflavones and their transformations during aging process. Moreover, the underlying mechanism responsible for the anti‐inflammatory effects primarily involves the inhibition of inflammatory factors through signaling pathways, such as mitogen‐activated protein kinases and nuclear factor‐erythroid 2‐related factor 2–antioxidant pathways. The interaction with gut microbiota also contributes to the anti‐inflammatory potential of CRP. In summary, this review offers valuable insights into the health benefits of CRP and its constituents, laying a solid foundation for the further development of CRP into anti‐inflammatory foods.

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In vitro human intestinal microbiota biotransformation of nobiletin using liquid chromatography–mass spectrometry analysis and background subtraction strategy

Cited by 12 publications

References 24 publications

A review on recent advances on nobiletin in central and peripheral nervous system diseases

A review on recent advances on nobiletin in central and peripheral nervous system diseases

Characterization of the chemical constituents and in vivo metabolic profile of Scutellaria barbata D. Don by ultra high performance liquid chromatography with high‐resolution mass spectrometry

Unveiling the potentials and action mechanisms of Citri reticulatae Pericarpium as an anti‐inflammatory food

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