In vitro human skin decontamination efficacy of MOF-808 in decontamination lotion following exposure to the nerve agent VX

Larsson, Andreas; Qvarnström, Johanna; Lindberg, Sandra; Wigenstam, Elisabeth; Öberg, Linda; Sander, Robin Afshin; Johansson, Susanne; Bucht, Anders; Thors, Lina

doi:10.1016/j.toxlet.2020.12.014

Cited by 10 publications

(10 citation statements)

References 44 publications

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“…The faster hydrolysis of VX compared to DMNP can be attributed to the higher reactivity of VX. 15,16 For comparison, the result previously 37 obtained with DTNB@ NU-1000(2), which had a similar loading of DTNB, is also included in Figure 2A. It is obvious that DTNB@MOF-808 displayed a substantial improvement in catalytic performance compared to our previously reported material.…”

Section: ■ Results and Discussionmentioning

confidence: 61%

“…3,4 These favorable features have led to the use of MOFs in a variety of potential applications including, but not limited to gas storage and separation, 5,6 drug storage and delivery, 7−9 catalysis, 10,11 and sensing. 12 In recent years, MOFs based on an octahedral Zr 6 cluster (e.g., UiO-66/67, 13,14 PCN-777, 15,16 MOF-808, 17 NU-901, 18,19 NU-1000, 20 and NU-1400 21 ) have attracted great interest as adsorbents and/or as catalysts in the degradation of extremely toxic organophosphorus (OP)-based chemical warfare agents (CWAs). 22 Such materials may find application in future personal protective equipment (e.g., clothing), 23−29 benign decontamination methods, 15,30 coatings, 31 as well as in detection.…”

Section: ■ Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…In recent years, MOFs based on an octahedral Zr 6 cluster (e.g., UiO-66/67, , PCN-777, , MOF-808, NU-901, , NU-1000, and NU-1400) have attracted great interest as adsorbents and/or as catalysts in the degradation of extremely toxic organophosphorus (OP)-based chemical warfare agents (CWAs) . Such materials may find application in future personal protective equipment (e.g., clothing), − benign decontamination methods, , coatings, as well as in detection . The relevance of developing countermeasures against OP-based CWAs is underscored by, for instance, the recent use of sarin in Syria (2013), the assassination of Kim Jong-Nam with VX (Malaysia, 2017), and the Novichok poisonings both in the United Kingdom (2018) and in Russia (2020)…”

Section: Introductionmentioning

confidence: 99%

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Development of a Metal–Organic Framework/Textile Composite for the Rapid Degradation and Sensitive Detection of the Nerve Agent VX

Koning

Grol

et al. 2022

Chem. Mater.

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In the case of an incident with nerve agents, the timely and ready detection and identification of such a substance on suspected surfaces is essential. However, the detection of low levels of nerve agents on a surface is a considerable challenge for conventional detection equipment, especially with VX, a highly toxic nerve agent with low volatility. Here, we report the development of a metal–organic framework (MOF)/fabric composite that gives a rapid, visual, and sensitive color response when pre-wetted and rubbed over a VX-contaminated surface. The fabric is composed of cotton textile modified with the zirconium-based MOF MOF-808 that possesses a bidentate reactive dye, ditopic 5,5-dithiobis(2-nitrobenzoic acid) (DTNB), on its nodes. The crystal structure of DTNB@MOF-808 showed that DTNB bridges between two adjacent nodes in MOF-808. The colorless composite changes to bright orange upon contact with VX as a result of the degradation of VX and the concomitant reaction of the dye with a VX degradation product in the MOF pores.

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Section: ■ Results and Discussionmentioning

confidence: 61%

Section: ■ Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Development of a Metal–Organic Framework/Textile Composite for the Rapid Degradation and Sensitive Detection of the Nerve Agent VX

Koning

Grol

et al. 2022

Chem. Mater.

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“…Following exposure to neat agent (10 μl) for 5 min, decontamination was performed according to the separate protocols described below (Section 2.4). The choice of exposure dose was based on previous studies to enable data comparisons and corresponds to approximately 2xLD 50 (0.07 mg kg −1 ) for a 70‐kg man (Larsson et al, 2020; NRC, 1997; Thors et al, 2020). The experimental time was 5 h and samples (200 μl) were collected every 10 min and kept at 10°C in a fraction collector (CMA 470 Refrigerated Fraction Collector; CMA Microdialysis AB, Kista, Sweden).…”

Section: Methodsmentioning

confidence: 99%

Do cold weather temperatures affect the efficacy of skin decontamination?

Thors

Wästerby

Wigenstam

et al. 2021

J of Applied Toxicology

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Skin decontamination in cold weather temperatures might be challenging due to the aggravating circumstances. However, no information is available on the efficacy of commonly used procedures in winter conditions. Therefore, the efficacy of the reactive skin decontamination lotion (RSDL) and soapy water decontamination following skin exposure to the nerve agent VX was evaluated at three ambient air temperatures (À5 C, À15 C and room temperature). Experiments were performed in vitro using human dermatomed skin. The ability of RSDL to degrade VX at the three different air temperatures was separately evaluated. The ambient air temperature in experiments without decontamination did not influence the penetration rate of VX through skin. RSDL decontamination was highly efficient in removing VX from skin when performed in all three ambient temperatures, despite the slower agent degradation rate of VX at the lower temperatures. Decontamination with soapy water at RT resulted in an increased skin penetration of VX compared with the control without decontamination; however, in colder temperatures the VX skin penetration was similar to the corresponding control without decontamination.At RT, dry removal prior to washing with soapy water did not improve decontamination of VX compared with washing solely with soapy water. This study demonstrated high efficacy of RSDL decontamination following skin exposure to VX also at cold temperatures. The previously reported 'wash-in' effect of soapy water on VX skin penetration was reduced at cold temperatures. Altogether, this study found a scientific basis to establish guidelines for skin decontamination of chemical casualties at cold weather temperatures.

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Metal–Organic Frameworks (MOFs) as Versatile Detoxifiers for Chemical Warfare Agents (CWAs)

Saya

Hooda

2022

Metal-Organic Frameworks (MOFs) as Catalysts

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In vitro human skin decontamination efficacy of MOF-808 in decontamination lotion following exposure to the nerve agent VX

Cited by 10 publications

References 44 publications

Development of a Metal–Organic Framework/Textile Composite for the Rapid Degradation and Sensitive Detection of the Nerve Agent VX

Development of a Metal–Organic Framework/Textile Composite for the Rapid Degradation and Sensitive Detection of the Nerve Agent VX

Do cold weather temperatures affect the efficacy of skin decontamination?

Metal–Organic Frameworks (MOFs) as Versatile Detoxifiers for Chemical Warfare Agents (CWAs)

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