In vitro/in vivo hepatoprotective properties of 1-O-(4-hydroxymethylphenyl)-α-L-rhamnopyranoside from Moringa oleifera seeds against carbon tetrachloride-induced hepatic injury

Sun, Congyong; Li, Wenjing; Liu, Yingkun; Deng, Wenwen; Adu‐Frimpong, Michael; Wang, Qilong; Yu, Jiangnan; Xu, Ximing

doi:10.1016/j.fct.2019.05.039

Cited by 31 publications

(19 citation statements)

References 49 publications

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“…However, pretreatments with the three assayed concentrations of Moringa oleifera significantly reduced hydrogen peroxide-induced ROS overproduction. Similar results were observed for moringa leaf flavonoids in bovine mammary epithelial cells against hydrogen peroxide and the compound 1-O-(4-hydroxymethylphenyl)-α-L-rhamnopyranoside from Moringa oleifera seeds against carbon against CCl 4 [ 43 , 44 ].…”

Section: Resultssupporting

confidence: 71%

Nutritional Value of Moringa oleifera Lam. Leaf Powder Extracts and Their Neuroprotective Effects via Antioxidative and Mitochondrial Regulation

et al. 2021

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Age-related neurodegenerative disorders are an increasing public health problem. Oxidative stress is one of the major causes. Medicinal plant-based functional foods can be effective for these diseases. The aim of this work is to investigate the neuroprotective role of methanol extracts of Moringa oleifera leaf powder on antioxidant/oxidant imbalance and mitochondrial regulation in a H2O2-induced oxidative stress model in human neuroblastoma cells. On nutritional analysis, results showed that moringa contained 28.50% carbohydrates, 25.02% proteins, 10.42% fat, 11.83% dietary fiber, 1.108 mg β-carotene, 326.4 µg/100 g vitamin B1 and 15.2 mg/100 g vitamin C. In-vitro assays revealed that moringa methanol extracts had more phenolic content and higher antioxidant activity than acetone extracts. Moreover, pretreatments with methanol extracts showed a protective effect against H2O2-induced oxidative damage through increasing cell viability and reducing free radicals. Furthermore, the extract decreased lipid peroxidation and enhanced glutathione levels and antioxidant enzyme activity. Finally, moringa also prevented mitochondrial dysfunction by regulating calcium levels and increasing mitochondrial membrane potential. The most active concentration was 25 µg/mL. In summary, the nutritional and functional properties of Moringa oleifera as a neuroprotective agent could be beneficial to protect against oxidative stress and provide necessary nutrients for a healthy diet.

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Section: Resultssupporting

confidence: 71%

Nutritional Value of Moringa oleifera Lam. Leaf Powder Extracts and Their Neuroprotective Effects via Antioxidative and Mitochondrial Regulation

et al. 2021

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“…Several isolated compounds were used in the study: isothiocyanates ( Waterman et al, 2015 ; Huang et al, 2020 ), niazirin ( Wang et al, 2019a ; Bao et al, 2020 ), β-sitosterol ( Liao et al, 2018 ). N, α, L-rhamnopyranosyl vincosamide, ( Panda et al, 2013 ; Cheraghi et al, 2017 ), 1-O-(4-hydroxymethylphenyl)-α-L-rhamnopyranoside (MPG) ( Sun et al, 2019 ). Additionally, some studies utilized isolated polysaccharides, proteins, and lectins from MO, which include the following: polysaccharides MRP-1 ( Cui et al, 2019 ), novel polysaccharides from MO leaves ( Li C. et al, 2020 ), water-soluble lectins ( Araújo et al, 2013 ; Yurre et al, 2020 ; Vera-Nunez et al, 2021 ), coagulant MO lectin ( Araújo et al, 2013 ), isolated protein from MO leaves ( Paula et al, 2017 ).…”

Section: Resultsmentioning

confidence: 99%

Moringa Oleifera Lam. in Cardiometabolic Disorders: A Systematic Review of Recent Studies and Possible Mechanism of Actions

2022

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Cardiometabolic disorders (CMD) have become a global emergency and increasing burden on health and economic problems. Due to the increasing need for new drugs for cardiometabolic diseases, many alternative medicines from plants have been considered and studied. Moringa oleifera Lam. (MO), one of the native plants from several Asian countries, has been used empirically by people for various kinds of illnesses. In the present systematic review, we aimed to investigate the recent studies of MO in CMD and its possible mechanism of action. We systematically searched from three databases and summarized the data. This review includes a total of 108 papers in nonclinical studies and clinical trials of MO in cardiometabolic-related disorders. Moringa oleifera, extracts or isolated compound, exerts its effect on CMD through its antioxidative, anti-inflammatory actions resulting in the modulation in glucose and lipid metabolism and the preservation of target organ damage. Several studies supported the beneficial effect of MO in regulating the gut microbiome, which generates the diversity of gut microbiota and reduces the number of harmful bacteria in the caecum. Molecular actions that have been studied include the suppression of NF-kB translocation, upregulation of the Nrf2/Keap1 pathway, stimulation of total antioxidant capacity by reducing PKCζ activation, and inhibiting the Nox4 protein expression and several other proposed mechanisms. The present review found substantial evidence supporting the potential benefits of Moringa oleifera in cardiovascular or metabolic disorders.

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“…Natural products and its derived active constituents normally known as phytobioactive compounds have recently been explored in the treatment of several diseases [57][58][59][60]. In recent times, our exploits in phytocompounds research support the assertion that natural products have the potential to prevent and treat oxidative stress-related inflammation which underlie liver disorders [61,62]. Exemplary, Zhang and his colleagues established previously that natural bioactive phytocompounds from fruits and vegetables could ameliorate the incidence of several illnesses, while those possessing anti-oxidant properties could potentially reduce severe adverse effects of anti-tumour drugs in Chinese women (Zhang et al, 2009) in particular and global population as a whole.…”

Section: Prevention and Treatment Prospects Of Natural Phytobioactive Compoundsmentioning

confidence: 96%

Prevention and Treatment of Methotrexate-induced Hepatotoxicity: Potential of Natural Phytobioactive Compounds<strong> </strong>

Adu‐Frimpong¹,

Abugri²,

Annor³

2021

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Methotrexate (MTX) is a potent drug for the treatment of various diseases globally amidst being a chemotherapeutic and immunosuppressant agent. However, hepatotoxicity induced by MTX could be life-threatening if left untreated. Folate supplementation is concurrently applied to reduce the adverse effects of MTX, albeit efficacy compromise. Therefore, there is the need to understand the process for the prevention and treatment strategies for MTX induced hepatotoxicity (MIH). In recent times, preliminary preclinical and clinical findings indicate the potential of natural phytobioactive compounds for MIH prevention and treatment. This mini review therefore summarizes proposed mechanisms of MIH and recent advances in the prevention and treatment prospects of natural phytobioactive compounds on MIH.

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In vitro/in vivo hepatoprotective properties of 1-O-(4-hydroxymethylphenyl)-α-L-rhamnopyranoside from Moringa oleifera seeds against carbon tetrachloride-induced hepatic injury

Cited by 31 publications

References 49 publications

Nutritional Value of Moringa oleifera Lam. Leaf Powder Extracts and Their Neuroprotective Effects via Antioxidative and Mitochondrial Regulation

Nutritional Value of Moringa oleifera Lam. Leaf Powder Extracts and Their Neuroprotective Effects via Antioxidative and Mitochondrial Regulation

Moringa Oleifera Lam. in Cardiometabolic Disorders: A Systematic Review of Recent Studies and Possible Mechanism of Actions

Prevention and Treatment of Methotrexate-induced Hepatotoxicity: Potential of Natural Phytobioactive Compounds<strong> </strong>

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