In vitro inhibition of α-glucosidases and glycogen phosphorylase by catechin gallates in green tea

Kamiyama, Ogusa; Sanae, Fujiko; Ikeda, Kyoko; Higashi, Yasuhiko; Minami, Yasuhiro; Asano, Naoki; Adachi, Isao; Kato, Atsushi

doi:10.1016/j.foodchem.2010.03.075

Cited by 109 publications

(84 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Theaflavins in black tea possess a potent antihyperglycemic function 41 ; the mechanism involves the delay or inhibition of glucose production in the small intestine by inhibiting of α-glucosidase activity. The same effects were observed for green tea polyphenols and procyanidins from French maritime pine bark extract pycnogenol 42,43 . Angelika et al also previously reported that the inhibitory effect of pycnogenol on α-glucosidase activity increased depending on the degree of polymerization of procyanidins 43 .…”

Section: Discussionsupporting

confidence: 70%

Effect of Dietary Polyphenols from Hop (Humulus lupulus L.) Pomace on Adipose Tissue Mass, Fasting Blood Glucose, Hemoglobin A1c, and Plasma Monocyte Chemotactic Protein-1 Levels in OLETF Rats

et al. 2013

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 70%

Effect of Dietary Polyphenols from Hop (Humulus lupulus L.) Pomace on Adipose Tissue Mass, Fasting Blood Glucose, Hemoglobin A1c, and Plasma Monocyte Chemotactic Protein-1 Levels in OLETF Rats

et al. 2013

View full text Add to dashboard Cite

“…Furthermore, in spite of abundant reports on the a-glucosidase inhibitory activities of extracts and pure compounds from plants from different parts of the world, only a few authors (21) reported such a low IC 50 value as found with the butanol fraction in our study. This observation might be connected to the high phenolic content recorded in this fraction, because polyphenolic fractions from plants have been shown to inhibit a-glucosidase activity, allowing for tighter control of blood glucose (22). Furthermore, Mai et al (23) reported a strong positive correlation between the polyphenolic content and a-glucosidase inhibitory effects of 28 extracts from Vietnamese edible plants, but also suggested that the enzymatic inhibition might depend on the type of polyphenolic.…”

Section: Resultsmentioning

confidence: 99%

Antioxidative Activity and Inhibition of Key Enzymes Linked to Type-2 Diabetes (α-Glucosidase and α-Amylase) by Khaya Senegalensis

Ibrahim

Koorbanally

Islam³

2014

Acta Pharmaceutica

View full text Add to dashboard Cite

Antioxidative activity and inhibition of key enzymes linked to type-2 diabetes (a-glucosidase and a-amylase)by Khaya senegalensis , respectively. Enzyme kinetic studies indicated that the butanol fraction is a non-competitive inhibitor for a-glucosidase with an inhibition binding constant K i of 1.30 µg mL -1 and a competitive inhibitor of a-amylase with a K i of 7.50 µg mL -1 . GC-MS analysis revealed that the butanol fraction contained two chromones, p-anilinophenol and 3-ethyl-5-(3-ethyl-(3H)-benzothiazol-2-ylidene)-2-(p-tolylvinylamino)-4-thiazolidinone. Data obtained in the study suggest that the butanol fraction derived from the ethanolic extract of K. senegalensis root possessed excellent antioxidative as well as a-glucosidase and a-amylase inhibitory activities while chromones and/or p-anilinophenol could be the main bioactive compounds responsible for the observed activities.

show abstract

“…The bark extract significantly chelates Fe 2+ in a concentration dependent manner (1-5 mg/mL). By chelating been shown to inhibit α-glucosidase activity, allowing for tighter control of blood glucose (Kamiyama et al 2010). The inhibitory effects of the extract of the B. sapida stem bark on the α-amylase and α-glucosidase activities may be attributed to the presence of phytochemicals such as polyphenols, tannins and saponins.…”

Section: Iron Chelating Abilitymentioning

confidence: 99%

Antioxidative Properties of Blighia sapida K.D. Koenig Stem Bark Extract and Inhibitory Effects on Carbohydrate Hydrolyzing Enzymes Associated with Non-Insulin Dependent Diabetes Mellitus

Ojo¹,

Ajiboye²,

Imiere³

et al. 2018

View full text Add to dashboard Cite

Background and aim:In Africa, the fruit, seed, leaf, and stem of Blighia sapida K.D. Koenig are used as remedy for a range of diseases. This study characterized the phytochemicals, assessed the antioxidant and inhibitory properties of the stem bark of Blighia sapida. Materials and methods: Samples were consecutively extracted using ethanol solvent and investigated for phenol content, DPPH radical scavenging abilities, iron chelation, reducing power, α-amylase and α-glucosidase activities as markers of in vitro anti-diabetic activities. Phytochemicals were analyzed using gas chromatography-mass spectrometry (GC-MS) analysis. Results: The extract had radical scavenging capabilities, iron chelation and reducing power. Furthermore, the results reveal the extract had considerably high α-glucosidase and α-amylase inhibitory activities as the concentration increases with IC 50 values of 4.17 ± 0.24 mg/mL and 5.30 ± 1.25 mg/mL, respectively. Enzyme kinetic studies indicated that the extract displayed uncompetitive inhibitor for α-glucosidase and was a competitive inhibitor of α-amylase. The ethanolic extract is rich in several aromatic phenolic compounds and long chain aliphatic acids. Conclusion: These results reveal the bark possessed antioxidant as well as α -glucosidase and α -amylase inhibitory activities.

show abstract

In vitro inhibition of α-glucosidases and glycogen phosphorylase by catechin gallates in green tea

Cited by 109 publications

References 28 publications

Effect of Dietary Polyphenols from Hop (Humulus lupulus L.) Pomace on Adipose Tissue Mass, Fasting Blood Glucose, Hemoglobin A1c, and Plasma Monocyte Chemotactic Protein-1 Levels in OLETF Rats

Effect of Dietary Polyphenols from Hop (Humulus lupulus L.) Pomace on Adipose Tissue Mass, Fasting Blood Glucose, Hemoglobin A1c, and Plasma Monocyte Chemotactic Protein-1 Levels in OLETF Rats

Antioxidative Activity and Inhibition of Key Enzymes Linked to Type-2 Diabetes (α-Glucosidase and α-Amylase) by Khaya Senegalensis

Antioxidative Properties of Blighia sapida K.D. Koenig Stem Bark Extract and Inhibitory Effects on Carbohydrate Hydrolyzing Enzymes Associated with Non-Insulin Dependent Diabetes Mellitus

Contact Info

Product

Resources

About