In vitro lipase inhibitory effect and kinetic properties of di-terpenoid fraction from Calotropis procera (Aiton)

Patil, S. R.; Patil, Mohini P.; Maheshwari, Vijay L.; Patil, Ravindra H.

doi:10.1016/j.bcab.2015.08.014

Cited by 23 publications

(7 citation statements)

References 19 publications

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“…The active ingredients of Panax ginseng, Panax quinquefolium, Panax japonicus, Aesculus turbinata, , green tea, gomchui, and oolong teas, Eisenia bicyclis, Glycyrrhiza uralensis, Acacia mearnsii, , Actinidia arguta, Rosmarinus officinalis, Salvia officinalis, Sapindus rarak, Ginkgo biloba, Calotropis procera, Dioscorea nipponica, and Cudrania tricuspidata as well as their plant parts used are shown in Table . These extracts inhibit pancreatic lipase to reduce plasma TGs and fat absorption, which reduces calories from fat intake.…”

Section: Mechanisms Of Anti-obesity Effect Of Natural Productsmentioning

confidence: 99%

Natural Products with Anti-obesity Effects and Different Mechanisms of Action

Jiang

Guo

et al. 2016

J. Agric. Food Chem.

170

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Obesity, a primary influence on health condition, causes numerous comorbidities and complications and, therefore, pharmacotherapy is considered a strategy for its treatment. However, the adverse effects of most chemical drugs targeting weight loss complicate their approval by regulatory authorities. Recently, interest has increased in the development of ingredients from natural sources with fewer adverse effects for preventing and ameliorating obesity. This review provides an overview of current anti-obesity drugs and natural products with anti-obesity properties as well as their mechanisms of action, which include interfering with nutrient absorption, decreasing adipogenesis, increasing energy expenditure (thermogenesis), appetite suppression, modifying intestinal microbiota composition, and increasing fecal fat excretion.

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Section: Mechanisms Of Anti-obesity Effect Of Natural Productsmentioning

confidence: 99%

Natural Products with Anti-obesity Effects and Different Mechanisms of Action

Jiang

Guo

et al. 2016

J. Agric. Food Chem.

170

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“…The experimental conditions employed for assessing pancreatic lipase inhibitory activity in this research exhibit certain resemblances and features when compared to the three referenced studies as presented in Table 6. Firstly, the utilization of p-NPP as the substrate in this study shares a common coloration mechanism with the p-nitrophenyl butyrate substrate employed in the investigations conducted by Patil et al (2015) [16] and Ananya et al (2015) [17]. Secondly, all four studies, including the present one, employed the Tris-HCl buffer system.…”

Section: Discussionmentioning

confidence: 91%

“…Secondly, all four studies, including the present one, employed the Tris-HCl buffer system. While this study maintained a pH of 8.0, Itoh et al (2019) [15] employed a similar pH value, and the remaining two studies were conducted at a pH of 7.0. Thirdly, all the tests were incubated at 37 °C, except for Patil et al (2015), which did not specify the incubation temperature.…”

Section: Discussionmentioning

confidence: 99%

In vitro study of effective factors for the inhibitory assay on pancreatic lipase

The

Trang

Cam

et al. 2023

JMP

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Background: Pancreatic lipase is one of the safest targets of anti-obesity drugs. To date, orlistat is the only pancreatic lipase inhibitor approved for the long-term treatment of obesity. Therefore, there is an elevated need to find new drugs for this disease. Determining the factors affecting the test to evaluate pancreatic lipase inhibitory activity in order to build a standard assay procedure is necessary. This will make it much easier for researchers to find novel compounds that inhibit the enzyme. Materials and method: The current study investigated the factors influencing pancreatic lipase activity and evaluated the enzyme inhibition of orlistat by spectrophotometric method at 405 nm using p-nitrophenyl palmitate as a substrate. Results: With the optimized conditions, the test to evaluate pancreatic lipase inhibitory activity of orlistat gave results similar to those published by other authors. Conclusion: The methodology of this work should be applied in the studies looking for new effective drugs to treat obesity. Key words: obesity, orlistat.

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“…Triterpenoids isolated from Scleroderma aurantium (3,25-Dihydroxy-22-acetoxyl-lanosta-8,23-diene) and Agrimonia pilosa have been reported to exhibit hypoglycaemic effects by scavenging free radicals and inhibiting α-glucosidase, thereby preventing glucose absorption and oxidative stress which has been implicated in the pathogenesis of diabetes mellitus [ 58 , 59 ]. The anti-diabetic activity of Calotropis procera mediated through the inhibition of pancreatic lipase activity has been attributed to the presence of terpenoid in the root extract [ 60 ]. Ursolic and oleanolic acids isolated from dried stems of Bouvardia terniflora have been reported to exhibit blood glucose-lowering effects in normal and alloxan-diabetic mice [ 61 ].…”

Section: Discussionmentioning

confidence: 99%

Anti-Diabetic Potential of Plant-Based Pentacyclic Triterpene Derivatives: Progress Made to Improve Efficacy and Bioavailability

et al. 2021

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Diabetes mellitus (DM) results from the inability of the pancreas to produce sufficient insulin or weakened cellular response to the insulin produced, which leads to hyperglycemia. Current treatments of DM focus on the use of oral hypoglycemic drugs such as acarbose, alpha-glucose inhibitors, sulphonylureas, thiazolidinediones, and biguanides to control blood glucose levels. However, these medications are known to have various side effects in addition to their bioavailability, efficacy, and safety concerns. These drawbacks have increased interest in the anti-diabetic potential of plant-derived bioactive compounds such as oleanolic and maslinic acids. Although their efficacy in ameliorating blood glucose levels has been reported in several studies, their bioavailability and efficacy remain of concern. The current review examines the anti-diabetic effects of oleanolic, maslinic, asiatic, ursolic, and corosolic acids and their derivatives, as well as the progress made thus far to enhance their bioavailability and efficacy. The literature for the current review was gathered from leading academic databases—including Google Scholar and PubMed—the key words listed below were used. The literature was searched as widely and comprehensively as possible without a defined range of dates.

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In vitro lipase inhibitory effect and kinetic properties of di-terpenoid fraction from Calotropis procera (Aiton)

Cited by 23 publications

References 19 publications

Natural Products with Anti-obesity Effects and Different Mechanisms of Action

Natural Products with Anti-obesity Effects and Different Mechanisms of Action

In vitro study of effective factors for the inhibitory assay on pancreatic lipase

Anti-Diabetic Potential of Plant-Based Pentacyclic Triterpene Derivatives: Progress Made to Improve Efficacy and Bioavailability

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