In-vitro mechanical and biological evaluation of novel zirconia reinforced bioglass scaffolds for bone repair

Gouveia, Paula F.; Mesquita‐Guimarães, J.; Galárraga-Vinueza, María Elisa; Souza, Júlio C. M.; Silva, Filipe; Fredel, Márcio C.; Boccaccını, Aldo R.; Detsch, Rainer; Henriques, Bruno

doi:10.1016/j.jmbbm.2020.104164

Cited by 25 publications

(32 citation statements)

References 49 publications

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“…During this process, a partial crystallization occurs, which limits the densification of the 45S5 bioactive glass. This is an important disadvantage for the use of 45S5 resulting from the sol-gel process for the production of bioactive substrates [65,66].…”

Section: Methods For Obtaining Bioactive Glassmentioning

confidence: 99%

Bioactive Glass—An Extensive Study of the Preparation and Coating Methods

Maximov

Crăciun

et al. 2021

Coatings

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Diseases or complications that are caused by bone tissue damage affect millions of patients every year. Orthopedic and dental implants have become important treatment options for replacing and repairing missing or damaged parts of bones and teeth. In order to use a material in the manufacture of implants, the material must meet several requirements, such as mechanical stability, elasticity, biocompatibility, hydrophilicity, corrosion resistance, and non-toxicity. In the 1970s, a biocompatible glassy material called bioactive glass was discovered. At a later time, several glass materials with similar properties were developed. This material has a big potential to be used in formulating medical devices, but its fragility is an important disadvantage. The use of bioactive glasses in the form of coatings on metal substrates allows the combination of the mechanical hardness of the metal and the biocompatibility of the bioactive glass. In this review, an extensive study of the literature was conducted regarding the preparation methods of bioactive glass and the different techniques of coating on various substrates, such as stainless steel, titanium, and their alloys. Furthermore, the main doping agents that can be used to impart special properties to the bioactive glass coatings are described.

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Section: Methods For Obtaining Bioactive Glassmentioning

confidence: 99%

Bioactive Glass—An Extensive Study of the Preparation and Coating Methods

Maximov

Crăciun

et al. 2021

Coatings

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“…The results of this study emphasise the significance of the chemical configuration on the surface, aperture diameter and microporosity in the utilisation of zirconia scaffolds as bone grafts. As mentioned previously, in 2020, Gouveia et al, used the protocol reported by Guimaraes et al, in 2019 for the synthesis of 58S bioactive glass and the fabrication of porous zirconia scaffolds reinforced with 58S bioactive glass [56]. Additionally, polyurethane sponges with 4, 60 and 80 pores per inch were fabricated.…”

Section: Sponge Replica Techniquementioning

confidence: 99%

Three-Dimensional Zirconia-Based Scaffolds for Load-Bearing Bone-Regeneration Applications: Prospects and Challenges

et al. 2021

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The design of zirconia-based scaffolds using conventional techniques for bone-regeneration applications has been studied extensively. Similar to dental applications, the use of three-dimensional (3D) zirconia-based ceramics for bone tissue engineering (BTE) has recently attracted considerable attention because of their high mechanical strength and biocompatibility. However, techniques to fabricate zirconia-based scaffolds for bone regeneration are in a stage of infancy. Hence, the biological activities of zirconia-based ceramics for bone-regeneration applications have not been fully investigated, in contrast to the well-established calcium phosphate-based ceramics for bone-regeneration applications. This paper outlines recent research developments and challenges concerning numerous three-dimensional (3D) zirconia-based scaffolds and reviews the associated fundamental fabrication techniques, key 3D fabrication developments and practical encounters to identify the optimal 3D fabrication technique for obtaining 3D zirconia-based scaffolds suitable for real-world applications. This review mainly summarized the articles that focused on in vitro and in vivo studies along with the fundamental mechanical characterizations on the 3D zirconia-based scaffolds.

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“…The treatment of large bone defects is a major medical problem worldwide. Biomaterial implantation is deemed an important option to promote bone reparation, but its efficiency remains a challenging issue [ [1] , [2] , [3] , [4] ]. Bone healing is a well-orchestrated process involving interactions among different complex biological events, including early inflammatory immune regulation, angiogenesis, osteogenic differentiation, and osteogenesis [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Sequential gastrodin release PU/n-HA composite scaffolds reprogram macrophages for improved osteogenesis and angiogenesis

Gui

et al. 2023

Bioactive Materials

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In-vitro mechanical and biological evaluation of novel zirconia reinforced bioglass scaffolds for bone repair

Cited by 25 publications

References 49 publications

Bioactive Glass—An Extensive Study of the Preparation and Coating Methods

Bioactive Glass—An Extensive Study of the Preparation and Coating Methods

Three-Dimensional Zirconia-Based Scaffolds for Load-Bearing Bone-Regeneration Applications: Prospects and Challenges

Sequential gastrodin release PU/n-HA composite scaffolds reprogram macrophages for improved osteogenesis and angiogenesis

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