In vitro methods used for discovering plant derived products as wound healing agents – An update on the cell types and rationale

Low, Jun Sheng; Mak, Kit‐Kay; Zhang, Shiming; Pichika, Mallikarjuna Rao; Marappan, Puvaneswari; Mohandas, Kavitha; Balijepalli, Madhu Katyayani

doi:10.1016/j.fitote.2021.105026

Cited by 12 publications

(7 citation statements)

References 62 publications

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“…Endothelial cells play an important role in the cutaneous immune system by recruiting inflammatory cells to the skin and inducing the release of cytokines and chemokines [ 29 ]. KCs represent an ideal cell model for the wound healing assay because they are involved in both oxidative stress and inflammation of the wound healing process [ 30 , 31 ]. P. notoginseng has been reported to promote tube formation in human umbilical vein endothelial cells [ 32 ], but its effects on KCs and MECs remain largely unexplored.…”

Section: Discussionmentioning

confidence: 99%

Sanchi-mediated inactivation of IL1B accelerates wound healing through the NFκB pathway deficit

Li,

Zhao,

Cui

et al. 2024

Heliyon

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Section: Discussionmentioning

confidence: 99%

Sanchi-mediated inactivation of IL1B accelerates wound healing through the NFκB pathway deficit

Li,

Zhao,

Cui

et al. 2024

Heliyon

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“…MMP-8 (matrix metalloproteinase-8) plays a role in wound healing by helping to resolve inflammation and allowing for the development of novel strategies for addressing wound healing abnormalities (Gutiérrez-Fernández et al 2007, Low et al 2021, Min et al 2021.…”

Section: Molecular Docking Studymentioning

confidence: 99%

LC-MS/MS metabolomics profiling of Glechoma hederacea L. methanolic extract; in vitro antimicrobial and in vivo with in silico wound healing studies on Staphylococcus aureus infected rat skin wound

El‐Aasr

Nohara

Ikeda

et al. 2022

Natural Product Research

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LC-MS/MS analysis of Glechoma hederacea L. methanolic extract (GHME), revealed the identification of 25 metabolites. Ursolic acid (1), 2α-hydroxyursolic acid or corosolic acid (2), 2β-hydroxyursolic acid or epi-corosolic (3), luteolin 7-O-β-Dglucopyranoside (4) and rosmarinic acid (5) were isolated and identified using spectroscopy.Antibacterial activity of GHME against multi drug resistance Staphylococcus aureus clinical isolates was measured. Minimum inhibitory concentrations (MICs) were ranged from 62.5 to 500 µg/ml. In vivo wound healing potential 2%, and 5% GHME prepared hydrogels were criticized on Staphylococcus aureus infected wound rat model. 5% GHME prepared hydrogel treated group showed significant (P<0.05) shrinkage of their colony forming unit/ml (CFU/ml) values in comparison with standard Fucidin. Meanwhile, wound closure associated with full re-epithelization and hair follicles proliferation was noticed after ten days of treatment. Finally, among the GHME isolated compounds, luteolin 7-O-β-D-glucopyranoside (4) exhibited the highest molecular docking score (-9.6 kcal/mol) against matrix metalloproteinase-8 (MMP-8) target.

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“…Since the skin is increasingly susceptible to burns and injuries from operations or traumas. Several things can trigger wounds, including external injuries, genetic conditions, minored abrasions, burns, and surgical procedures [ 9 ]. Impaired healing can impact the recovery of various types of wounds, including both acute wounds (surgical incisions or traumatic injuries) and chronic wounds (diabetic foot ulcers).…”

Section: Introductionmentioning

confidence: 99%

Electrospun nanofibers synthesized from polymers incorporated with bioactive compounds for wound healing

Palani,

Vijayakumar,

Monisha

et al. 2024

J Nanobiotechnol

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The development of innovative wound dressing materials is crucial for effective wound care. It’s an active area of research driven by a better understanding of chronic wound pathogenesis. Addressing wound care properly is a clinical challenge, but there is a growing demand for advancements in this field. The synergy of medicinal plants and nanotechnology offers a promising approach to expedite the healing process for both acute and chronic wounds by facilitating the appropriate progression through various healing phases. Metal nanoparticles play an increasingly pivotal role in promoting efficient wound healing and preventing secondary bacterial infections. Their small size and high surface area facilitate enhanced biological interaction and penetration at the wound site. Specifically designed for topical drug delivery, these nanoparticles enable the sustained release of therapeutic molecules, such as growth factors and antibiotics. This targeted approach ensures optimal cell-to-cell interactions, proliferation, and vascularization, fostering effective and controlled wound healing. Nanoscale scaffolds have significant attention due to their attractive properties, including delivery capacity, high porosity and high surface area. They mimic the Extracellular matrix (ECM) and hence biocompatible. In response to the alarming rise of antibiotic-resistant, biohybrid nanofibrous wound dressings are gradually replacing conventional antibiotic delivery systems. This emerging class of wound dressings comprises biopolymeric nanofibers with inherent antibacterial properties, nature-derived compounds, and biofunctional agents. Nanotechnology, diminutive nanomaterials, nanoscaffolds, nanofibers, and biomaterials are harnessed for targeted drug delivery aimed at wound healing. This review article discusses the effects of nanofibrous scaffolds loaded with nanoparticles on wound healing, including biological (in vivo and in vitro) and mechanical outcomes. Graphical Abstract

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In vitro methods used for discovering plant derived products as wound healing agents – An update on the cell types and rationale

Cited by 12 publications

References 62 publications

Sanchi-mediated inactivation of IL1B accelerates wound healing through the NFκB pathway deficit

Sanchi-mediated inactivation of IL1B accelerates wound healing through the NFκB pathway deficit

LC-MS/MS metabolomics profiling of Glechoma hederacea L. methanolic extract; in vitro antimicrobial and in vivo with in silico wound healing studies on Staphylococcus aureus infected rat skin wound

Electrospun nanofibers synthesized from polymers incorporated with bioactive compounds for wound healing

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