In vitro microbicidal activity of W/O/W multiple emulsion for vaginal administration

Tedajo, G.M; Bouttier, Sylvie; Grossiord, J. L.; Marty, Jean‐Paul; Seiller, M.; Fourniat, J.

doi:10.1016/s0924-8579(02)00108-5

Cited by 7 publications

(6 citation statements)

References 6 publications

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“…Multiple emulsions are a specific case of emulsion systems whose manufacturing requires both lipophilic and hydrophilic surfactants (see Table 5 ). A non-ionic silicone based Abil EM 90 W/O emulsifier is the most commonly used lipophilic surfactant in the formation of internal emulsion, while a hydrophilic surfactant, e.g., poloxamer 407 provides w/o/w multiple emulsion stability by encapsulation of w/o emulsion in external aqueous phase [ 89 , 101 , 102 , 103 , 104 ]. In turn, obtaining SEDDS formulations is a difficult process due to the limited number of oil-surfactant combinations capable of forming these systems (see Table 6 ).…”

Section: Technological Aspects Of Vaginal Formulations Developmentmentioning

confidence: 99%

“…Among other excipients used in vaginal emulsion systems the addition of lactic acid or phosphate buffers for pH regulation were reported [ 75 , 92 , 101 ], while propylene glycol and PEG 200 have been applied as humectants [ 77 ]. Benzyl alcohol, sodium benzoate, chlorocresol, methylparaben are used as preservatives [ 82 , 84 , 95 ].…”

Section: Technological Aspects Of Vaginal Formulations Developmentmentioning

confidence: 99%

“…In the first step inner W/O emulsion is prepared through the addition of aqueous media containing electrolytes into a mixture of oil phase and surfactants (S mix ) at 80 °C under continuous stirring. In the second step the previously obtained W/O emulsion cooled to room temperature is slowly added to the external aqueous phase that contains hydrophilic surfactant(s) [ 71 , 89 , 101 , 102 , 104 ].…”

Section: Technological Aspects Of Vaginal Formulations Developmentmentioning

confidence: 99%

“…For other reported formulations the pH values were higher and fell within the slightly acidic range, also considered as physiological [ 78 , 85 , 91 , 94 , 95 , 96 , 97 , 102 ]. Some of the formulations pH values exceeded physiological range [ 89 , 90 , 101 ], creating a risk of bacterial infections. None of the analyzed publications provided information on the osmolarity value of the obtained formulations which, due to the risk of irritation and damage to the vaginal mucosa, should be <1200 mOsm/kg [ 45 ].…”

Section: Technological Aspects Of Vaginal Formulations Developmentmentioning

confidence: 99%

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Emulsion-Based Multicompartment Vaginal Drug Carriers: From Nanoemulsions to Nanoemulgels

Smoleński

Karolewicz

Gołkowska

et al. 2021

IJMS

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In order to overcome the limitations associated with vaginal administration of drugs, e.g., the short contact time of the drug form with the mucosa or continuous carrier wash-out, the development of new carriers for gynecological use is necessary. Furthermore, high individual anatomical and physiological variability resulting in unsatisfactory therapeutic efficacy of lipophilic active substances requires application of multicompartment drug delivery systems. This manuscript provides an up-to-date comprehensive review of the literature on emulsion-based vaginal dosage forms (EVDF) including macroemulsions, microemulsions, nanoemulsions, multiple emulsions and self-emulsifying drug delivery systems. The first part of the paper discusses (i) the influence of anatomical-physiological conditions on therapeutic efficacy of drug forms after local and systemic administration, (ii) characterization of EVDF components and the manufacturing techniques of these dosage forms and (iii) methods used to evaluate the physicochemical and pharmaceutical properties of emulsion-based vaginal dosage forms. The second part of the paper presents (iv) the results of biological and in vivo studies as well as (v) clinical evaluation of EVDF safety and therapeutic efficacy across different indications.

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Section: Technological Aspects Of Vaginal Formulations Developmentmentioning

confidence: 99%

Section: Technological Aspects Of Vaginal Formulations Developmentmentioning

confidence: 99%

Section: Technological Aspects Of Vaginal Formulations Developmentmentioning

confidence: 99%

Section: Technological Aspects Of Vaginal Formulations Developmentmentioning

confidence: 99%

See 2 more Smart Citations

Emulsion-Based Multicompartment Vaginal Drug Carriers: From Nanoemulsions to Nanoemulgels

Smoleński

Karolewicz

Gołkowska

et al. 2021

IJMS

View full text Add to dashboard Cite

show abstract

“…These emulsion systems, at least in theory, have significant potential in pharmacy and cosmetics (prolonged release of actives substances, the possibility of combining incompatible substances in one product, the protection of fragile substances) [1–4]. In practice, multiple emulsions are thermodynamically unstable with strong tendency for coalescence, flocculation and creaming.…”

Section: Introductionmentioning

confidence: 99%

The characterization of the semi‐solid W/O/W emulsions with low concentrations of the primary polymeric emulsifier

Vasiljević

Vuleta

Primorac

2005

Intern J of Cosmetic Sci

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Semi-solid multiple W/O/W emulsions with low concentrations (0.8, 1.6 and 2.4% w/w) of lipophilic polymeric primary emulsifier PEG-30-dipolyhydroxystearate (PDHS) have been formulated. Both emulsions, primary and multiple, were prepared with high content of inner phase (Phi1 = Phi2 = 0.8). All the formulations differ only in the lipophilic emulsifier concentration. Evaluating several parameters such as macroscopic and microscopic aspect, droplet size, accelerated stability under centrifugation and flow and oscillatory rheological behaviour, assessed the multiple systems. It is possible to formulate the semi-solid W/O/W multiple emulsions with low concentrations of PDHS as the primary emulsifier. It appeared that the highest long-term stable multiple emulsion with the lowest droplet size, the highest apparent viscosity and highest elastic characteristic, was the sample with the highest concentration (2.4% w/w) of the primary emulsifier.

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Vaginal Drug Delivery

Neves

Amaral

Bahia

2010

Pharmaceutical Sciences Encyclopedia

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The vagina has been used for a long time as a route for drug administration. Vaginal drug delivery has seen recent advances that make it very promising, in particular therapeutic fields such as the prevention of human immunodeficiency virus (HIV) and other sexually transmitted infections, and contraception. This article discusses the main features of vaginal anatomy, physiology, and histology related to drug delivery as well as vaginal drug delivery systems and their evaluation, current usage of the vagina as a route of drug administration, and promising strategies in this field.

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In vitro microbicidal activity of W/O/W multiple emulsion for vaginal administration

Cited by 7 publications

References 6 publications

Emulsion-Based Multicompartment Vaginal Drug Carriers: From Nanoemulsions to Nanoemulgels

Emulsion-Based Multicompartment Vaginal Drug Carriers: From Nanoemulsions to Nanoemulgels

The characterization of the semi‐solid W/O/W emulsions with low concentrations of the primary polymeric emulsifier

Vaginal Drug Delivery

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