In vitro permeation through porcine buccal mucosa of Salvia desoleana Atzei &amp; Picci essential oil from topical formulations

Ceschel, G. C.; Maffei, Paola; Moretti, Mario Domenico Luigi; Demontis, S.; Peana, Alessandra Tiziana

doi:10.1016/s0378-5173(99)00381-6

Cited by 37 publications

(18 citation statements)

References 9 publications

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“…Previous reports suggest that linalool and some terpenoids can enhance the permeability of numerous drugs through biological tissues such as skin and mucus membranes. [31][32][33] Various terpenoids show PPAR ligand activity. They regulate inflammatory processes such as diabetes mellitus, hyperlipidemia, and cardiovascular disease, which are associated with low-grade chronic inflammation.…”

Section: Discussionmentioning

confidence: 99%

Kuromoji (Lindera umbellata) Essential Oil Inhibits LPS-Induced Inflammation in RAW 264.7 Cells

Maeda

Yamazaki

Katagata

2013

Bioscience, Biotechnology, and Biochemistry

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Kuromoji (Lindera umbellata) essential oil (KEO) has long been used in Japan as a traditional medicine. It contains linalool (C 10 H 18 O), a naturally occurring small terpenoid. For this study, we investigated the antiinflammatory effect of KEO in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. Mouse macrophage-like RAW 264.7 cells were stimulated with LPS. Then they were treated with 25 or 50 g/mL of KEO for 24 h. KEO suppressed LPS-induced pro-inflammatory cytokine production such as that of nitric oxide (NO), interleukin-6 (IL-6), and tumor necrosis factor-(TNF-) in a dose-dependent manner. In addition, inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) mRNA expression and protein levels were suppressed by treatment with KEO cells. In addition, by treatment with 25 or 50 g/mL of linalool showed the same anti-inflammatory effect. The results suggest that KEO and linalool can be regarded as a natural resource for use in anti-inflammatory therapeutic products.

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Section: Discussionmentioning

confidence: 99%

Kuromoji (Lindera umbellata) Essential Oil Inhibits LPS-Induced Inflammation in RAW 264.7 Cells

Maeda

Yamazaki

Katagata

2013

Bioscience, Biotechnology, and Biochemistry

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“…The receiver chambers of these diffusion cells are typically maintained at 37°C while the donor chamber is kept at ambient temperature, typically 22-24°C (31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43). Such an experimental setup for in vitro permeation studies across the buccal mucosa does not mimic the in vivo condition.…”

Section: Introductionmentioning

confidence: 99%

Effect of Experimental Temperature on the Permeation of Model Diffusants Across Porcine Buccal Mucosa

Kulkarni

Ravichandran

et al. 2011

AAPS PharmSciTech

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Abstract. The influence of experimental temperature on the permeability of model diffusants across porcine buccal mucosa was investigated in vitro. The permeability increased significantly as the experimental temperature was increased in increments of approximately 7°C. It was observed that the apparent permeability and temperature were related by an exponential relationship that conformed to the Arrhenius equation. Diffusants with higher lipophilicities-buspirone and bupivacaine-had lower activation energies for diffusion when compared to hydrophilic diffusants-antipyrine and caffeine. The activation energy for diffusion of the model diffusants decreased linearly with increasing distribution coefficients across porcine buccal mucosa. The results suggested that the buccal mucosa acts as a stronger barrier to the diffusion of hydrophilic diffusants than the lipophilic ones. The log-linear relationship between permeability and temperature indicates that temperature should be carefully controlled in diffusion experiments. These results also point to the possibility of developing heat-generating buccal delivery devices, especially for hydrophobic diffusants.

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“…Salvia desoleana, an indigenous Sardinian species, [2] is used in folk medicine to treat menstrual, digestive and central nervous system diseases. [3][4][5][6][7] The antimicrobial activity of S. desoleana essential oil has been screened against some Gram-positive and Gram-negative bacterial strains and Candida albicans. [8] The essential oils of Salvia fruticosa and S. pomifera subsp.…”

Section: Introductionmentioning

confidence: 99%

Chemical composition and antifungal activity of Salvia desoleana Atzei & Picci essential oil and its major components

Sokóvić¹,

Brkić

Džamić

et al. 2009

Flavour & Fragrance J

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The antifungal activity of Salvia desoleana Atzei & Picci (Labiatae) essential oil and its three components was investigated against 17 micromycetes. Among the species tested were food-poisoning fungi and plant, animal and human pathogens. In order to determine minimum inhibitory concentrations (MICs) of the total essential oils and their components, mycelial growth and microdilution tests were used. The essential oil of S. desoleana and linalool possessed strong antifungal activity, 1,8-cineole showed only moderate antifungal potential, while linalyl acetate possessed a lower antifungal potential.

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In vitro permeation through porcine buccal mucosa of Salvia desoleana Atzei & Picci essential oil from topical formulations

Cited by 37 publications

References 9 publications

Kuromoji (Lindera umbellata) Essential Oil Inhibits LPS-Induced Inflammation in RAW 264.7 Cells

Kuromoji (Lindera umbellata) Essential Oil Inhibits LPS-Induced Inflammation in RAW 264.7 Cells

Effect of Experimental Temperature on the Permeation of Model Diffusants Across Porcine Buccal Mucosa

Chemical composition and antifungal activity of Salvia desoleana Atzei & Picci essential oil and its major components

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