IJPS 2024
DOI: 10.36468/pharmaceutical-sciences.1308
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In Vitro Studies on the Effects of Water Miscible Organic Co-Solvents on Select Drug Metabolizing Enzyme Activities

K. R. Iyer,
S. H. Kamble,
T. S. Shah
et al.

Abstract: Iyer et al.: Effect of Organic Solvents on Drug Metabolizing EnzymesOrganic solvents are extensively used in in vitro drug metabolism studies to overcome the solubility issues of lipophilic substrate/new chemical entities. The effects of ten common water miscible organic solvents on cytochrome P450s and non-cytochrome P450 enzymes, namely, flavin monooxygense, aldehyde oxidase, xanthine oxidase, esterases and glutathione S-transferases were evaluated. Rat liver microsomes and rat liver cytosol were used for cy… Show more

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