In vitro studies to evaluate the wound healing properties of Calendula officinalis extracts

Medicinal plants with wound healing potential

“…The nhexane extract was found to increase the activity of transcription factor NF-κB and the extract also increased the chemokine (Interleukin-8) in human immortalized keratinocytes. Migration and spreading of keratinocytes were little influenced in the scratch assay (Nicolaus et al, 2017).…”

“…Medicinal plant extracts also endorse wound healing by activation of interleukin-8. The n-hexane extract C. officinalis was found to increase the activity of interleukin-8 in human immortalized keratinocytes (Nicolaus et al, 2017).…”

“…It has been demonstrated that plant extract can promote wound healing by NF-κB activation. The n-hexane extract of C. officinalis has been reported to increase the activity of transcription factor NF-κB in human immortalized keratinocytes and dermal fibroblast cells (Nicolaus et al, 2017).…”

“…Recently many plant extracts have been reported for wound healing activity and their cellular mechanism of wound healing has been studied extensively. It has been demonstrated that many plant extracts processed wound healing via angiogenesis (Mirmalek et al, 2015;Shen et al, 2017), activation of NF-κB (Nicolaus et al, 2017), favoring proinflammatory cytokines (Joshi et al, 2016), upregulation of iNOS (Pereira et al, 2016) and alpha-1 type-1 collagen (Krishnappa et al, 2016), fibroblast proliferation (Seyed et al, 2016;Öz et al, 2016), and anti-oxidant activity (Joshi et al, 2016). Thus, the aim of this review was to collect information about the cellular mechanisms of wound healing plants recently reported by the investigators and present them in an organized or systematic way.…”

Anti-Inflammatory and Healing Potential of Phytoderivatives in Cutaneous Rabbits Wounds

“…[7, 9,41,45,46] The A. santureioides extract, a popular species consumed worldwide, may exhibit prevention of oxidative stress on the skin [19] and cytogenotoxic effect in vivo and in vitro [47] probably due to the high concentration of the flavonoids luteolin, quercetin and 3-O-methylquercetin; the low concentrations usually consumed by this plant are safe and do not present risks. [21,48] It is a plant that works to reduce the influx of neutrophils and secretion of leukotriene B4 at the site of inflammation, blocking the expression/activity of molecules involved in the interaction between immunocirculating cells and endothelial cells, reducing the body's innate response without causing systemic toxicity.…”