In vitro studies with renal proximal tubule cells show direct cytotoxicity of Androctonus australis hector scorpion venom triggered by oxidative stress, caspase activation and apoptosis

Saidani, Chanez; Hammoudi-Triki, Djelila; Laraba-Djebari, Fatima; Taub, Mary

doi:10.1016/j.toxicon.2016.07.012

Cited by 8 publications

(4 citation statements)

References 41 publications

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“…The wavelengths were set as follows: Excitation, 640 nm; emission, 665 nm. All the experiments were repeated at least three times, and representative results are shown in each figure (11,12).…”

Section: Methodsmentioning

confidence: 99%

Baicalin potentiates TRAIL-induced apoptosis through p38 MAPK activation and intracellular reactive oxygen species production

Zhang

Wang

Zheng

et al. 2017

Molecular Medicine Reports

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The combination of tumor necrosis factor‑related apoptosis‑inducing ligand (TRAIL) with other agents has been recognized as a promising strategy to overcome TRAIL resistance in cancer cells. Baicalin (5, 6‑dihydroxy‑7‑o‑glucuronide flavone) is a flavonoid from the root of the medicinal herb Scutellaria baicalensis Georgi, which has been reported to exert antioxidant, anti‑inflammatory, antiviral and anticancer activities in vitro. However, the effect of baicalin on TRAIL‑induced cytotoxicity has not been previously reported. In the present study, the effect of combining TRAIL and baicalin was investigated in non‑small cell lung cancer cell lines. The results revealed that baicalin was able to sensitize A549 and H2009 cells to TRAIL‑induced apoptosis. This was detected by the potentiation of poly‑adenosine‑5'‑diphosphate‑ribose polymerase cleavage and Annexin V‑fluorescein isothiocyanate staining of cells co‑treated with baicalin and TRAIL. In addition, p38 mitogen‑activated protein kinase was activated in baicalin and TRAIL co‑treated cancer cells, whereas the p38 inhibitor SB203580 effectively suppressed cell death within the co‑treated cells. Butylated hydroxyanisole and N‑acetyl‑cysteine, known reactive oxygen species (ROS) scavengers, significantly suppressed the potentiated cytotoxicity induced by baicalin and TRAIL co‑treatment. The present study is the first, to the best of our knowledge, to demonstrate that baicalin enhances the anticancer activity of TRAIL via p38 activation and ROS accumulation, and may be exploited for anticancer therapy.

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Section: Methodsmentioning

confidence: 99%

Baicalin potentiates TRAIL-induced apoptosis through p38 MAPK activation and intracellular reactive oxygen species production

Zhang

Wang

Zheng

et al. 2017

Molecular Medicine Reports

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“…269,271,275,276 The mechanisms of renal injury are likely renal ischemia due to vasoconstriction, hemodynamic instability, rhabdomyolysis, excessive systemic inflammation, and direct venom nephrotoxicity. 269,271,272,277 Renal histology shows ATN, glomerular changes, interstitial infiltrate, thrombotic microangiopathy, and CN. 269,272,[276][277][278][279] A casecontrol study in Mexico suggested that scorpion accidents were associated with development of CKD in children.…”

Section: Leptospirosismentioning

confidence: 99%

“…269,271,272,277 Renal histology shows ATN, glomerular changes, interstitial infiltrate, thrombotic microangiopathy, and CN. 269,272,[276][277][278][279] A casecontrol study in Mexico suggested that scorpion accidents were associated with development of CKD in children. 280 Use of antivenom partially decreased kidney venom concentration in a mice model, and has been associated with more favorable clinical outcome.…”

Section: Leptospirosismentioning

confidence: 99%

Acute kidney injury due to tropical infectious diseases and animal venoms: a tale of 2 continents

Burdmann

Jha

2017

Kidney International

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South and Southeast Asia and Latin American together comprise 46 countries and are home to approximately 40% of the world population. The sociopolitical and economic heterogeneity, tropical climate, and malady transitions characteristic of the region strongly influence disease behavior and health care delivery. Acute kidney injury epidemiology mirrors these inequalities. In addition to hospital-acquired acute kidney injury in tertiary care centers, these countries face a large preventable burden of community-acquired acute kidney injury secondary to tropical infectious diseases or animal venoms, affecting previously healthy young individuals. This article reviews the epidemiology, clinical picture, prevention, risk factors, and pathophysiology of acute kidney injury associated with tropical diseases (malaria, dengue, leptospirosis, scrub typhus, and yellow fever) and animal venom (snakes, bees, caterpillars, spiders, and scorpions) in tropical regions of Asia and Latin America, and discusses the potential future challenges due to emerging issues.

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“…184,186 The mechanisms are direct nephrotoxicity, renal vasoconstriction, hemodynamic instability, rhabdomyolysis, systemic inflammation, haemoglobinuria and mitochondrial dysfunction. 184,186,187,189 Renal histology includes ATN, glomerulopathy, interstitial infiltration, TMA and ACN. 184,186,187,190 There is an association with CKD in children.…”

Section: Scorpionsmentioning

confidence: 99%

Acute kidney injury in the tropics

et al. 2022

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The tropics are a region consisting of more than 125 countries, accounting for 40% of the world's population. The region's population is expected to increase up to 60% in the coming decades. Many tropical countries continue to experience public health problems such as high rates of infectious diseases, lack of sanitation, climate change impacts, poor regulation of herbal medicines and low access to healthcare. These conditions produce the unique problem of tropical acute kidney injury (AKI), which is associated with high morbidity and mortality. Tropical infections such as leptospirosis, dengue and malaria have varied mechanisms of AKI, including both direct kidney invasion and indirect effects, depending on the disease characteristics. Animal toxins from snakebites and arthropods along with plant toxins, such as djenkol beans, starfruit and herbal medicine, are characterized by a harmful renal effect from each toxic substance. Environmental factors such as heat stress, natural disasters and chemical compounds also lead to AKI and have a systemic effect from their own pathogenesis. The long‐term kidney prognosis varies among these etiologies depending on the cause and severity of disease. However, all these conditions are potentially preventable and treatable. Prompt management and good preventive approaches are needed. This article will focus on the epidemiology, pathogenesis and management of AKI associated with tropical infections, toxins and environment impacts.

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In vitro studies with renal proximal tubule cells show direct cytotoxicity of Androctonus australis hector scorpion venom triggered by oxidative stress, caspase activation and apoptosis

Cited by 8 publications

References 41 publications

Baicalin potentiates TRAIL-induced apoptosis through p38 MAPK activation and intracellular reactive oxygen species production

Baicalin potentiates TRAIL-induced apoptosis through p38 MAPK activation and intracellular reactive oxygen species production

Acute kidney injury due to tropical infectious diseases and animal venoms: a tale of 2 continents

Acute kidney injury in the tropics

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