In-Vitro Susceptibility Testing by Agar Dilution Method to Determine the Minimum Inhibitory Concentrations of Amphotericin B, Fluconazole and Ketoconazole Against Ocular Fungal Isolates

Therese, K Lily; Bagyalakshmi, R; Hn, Madhavan; Deepa, Perinkulam Ravi

doi:10.1016/s0255-0857(21)02288-x

Indian Journal of Medical Microbiology

2006

DOI: 10.1016/s0255-0857(21)02288-x

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In-Vitro Susceptibility Testing by Agar Dilution Method to Determine the Minimum Inhibitory Concentrations of Amphotericin B, Fluconazole and Ketoconazole Against Ocular Fungal Isolates

K Lily Therese

R Bagyalakshmi

Madhavan Hn

et al.

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Cited by 2 publications

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Evaluation of the Antifungal Activity of Fluconazole Nanovesicles Against Aspergillus fumigatus

Osman,

. Altoum,

Shadroch

et al. 2024

Biomed. Pharmacol. J.

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Fluconazole is potent triazole drug used as effectively anti-fungal for treating a variety of local and systemic fungal infections. This drug is sparingly soluble in water. The objective of this research was to statistically optimize nanovesicular formulations contain fluconazole to improve its antifungal effect. The nanovesicular formulations were composed of Tween® 80, cetyl alcohol, and chitosan. The prepared nanovesicular formulations were investigated for their zeta potential, polydispersity index, particle size, and encapsulation efficiency. The nanovesicular that has been optimized formulation was consist of tween/cetyl alcohol ratio of 15:1 and 0.1% chitosan. Additionally, the optimized formulation increased significantly in fluconazole release ratio and extent in comparison to the suspension form of the drug. The find that fluconazole nanovesicles had a better effect and lower MIC when compared to the aqueous fluconazole suspension. Finally, the optimized nanovesicles can be considered a promising nanocarrier for delivery of fluconazole to increase its systemic antifungal efficacy.

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Evaluation of the Antifungal Activity of Fluconazole Nanovesicles Against Aspergillus fumigatus

Osman,

. Altoum,

Shadroch

et al. 2024

Biomed. Pharmacol. J.

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show abstract

Evaluation of Biological Activity of Natural Compounds: Current Trends and Methods

et al. 2022

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Natural compounds have diverse structures and are present in different forms of life. Metabolites such as tannins, anthocyanins, and alkaloids, among others, serve as a defense mechanism in live organisms and are undoubtedly compounds of interest for the food, cosmetic, and pharmaceutical industries. Plants, bacteria, and insects represent sources of biomolecules with diverse activities, which are in many cases poorly studied. To use these molecules for different applications, it is essential to know their structure, concentrations, and biological activity potential. In vitro techniques that evaluate the biological activity of the molecules of interest have been developed since the 1950s. Currently, different methodologies have emerged to overcome some of the limitations of these traditional techniques, mainly via reductions in time and costs. These emerging technologies continue to appear due to the urgent need to expand the analysis capacity of a growing number of reported biomolecules. This review presents an updated summary of the conventional and relevant methods to evaluate the natural compounds’ biological activity in vitro.

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In-Vitro Susceptibility Testing by Agar Dilution Method to Determine the Minimum Inhibitory Concentrations of Amphotericin B, Fluconazole and Ketoconazole Against Ocular Fungal Isolates

Cited by 2 publications

References 17 publications

Evaluation of the Antifungal Activity of Fluconazole Nanovesicles Against Aspergillus fumigatus

Evaluation of the Antifungal Activity of Fluconazole Nanovesicles Against Aspergillus fumigatus

Evaluation of Biological Activity of Natural Compounds: Current Trends and Methods

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