In vitro toxicological evaluation of ionic liquids and development of effective bioremediation process for their removal

Thamke, Viresh; Chaudhari, Ashvini U.; Tapase, Savita R.; Paul, Dhiraj; Kodam, Kisan M.

doi:10.1016/j.envpol.2019.04.043

Cited by 31 publications

(25 citation statements)

References 57 publications

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“…Several of these MoAs of ILs have been observed, more specifically: Alterations in mitochondrial membrane potential and permeabilization have been reported in A431 cells incubated in [C 15 mim][Cl] ILs (Malhotra et al 2014 ). Decrease in mitochondrial membrane potential has been observed in MDA-MB-231 cells incubated in [C 4 mim][Br] and [C 10 mim][BF 4 ] (Thamke et al 2019 ), see Fig. 13 .…”

Section: Mechanisms Of Action Of Ilsmentioning

confidence: 98%

“…Decrease in mitochondrial membrane potential has been observed in MDA-MB-231 cells incubated in [C 4 mim][Br] and [C 10 mim][BF 4 ] (Thamke et al 2019 ), see Fig. 13 .…”

Section: Mechanisms Of Action Of Ilsmentioning

confidence: 98%

“…13 Shift in the mitochondrial membrane potential of MDA-MB-231 cells treated with various ILs. Figure taken from Thamke et al ( 2019 ) and reproduced with permission from the publisher

Fig. 14 Representative pictures from live cell imaging of JC-1 stained RT112 cells a 1 h, b 2 h, and c 4 h after a treatment with 200 mM TPP1 IL.…”

Section: Mechanisms Of Action Of Ilsmentioning

confidence: 99%

“… Shift in the mitochondrial membrane potential of MDA-MB-231 cells treated with various ILs. Figure taken from Thamke et al ( 2019 ) and reproduced with permission from the publisher …”

Section: Mechanisms Of Action Of Ilsmentioning

confidence: 99%

“…Because the first ILs showed a clear green character, there was the assumption, if not the hope, that this could be extended to all the ILs (Petkovic et al 2011 ; Earle and Seddon 2000 ). However, in the 2000s, several biological studies highlighted a moderate-to-high toxicity of ILs towards several micro-organisms, plants, cell lines, and potentially humans (Bernot et al 2005 ; Pretti et al 2006 ; Pham et al 2008 ; Studzińska and Buszewski 2009 ; Matzke et al 2009 ; Li et al 2009 ; Coleman and Gathergood 2010 ; Frade and Afonso 2010 ; Costa et al 2017 ; Bubalo et al 2017 ; Thamke et al 2019 ; Pawłowska et al 2019 ; Leitch et al 2020a ; Leitch et al 2020b ). For example, ILs based on amino acids (Benedetto et al 2014a ), which were supposed to be more bio-friendly, turned out to have higher toxicity level than their common counterparts (Egorova et al 2015 ).…”

Section: Introductionmentioning

confidence: 99%

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Mechanisms of action of ionic liquids on living cells: the state of the art

2020

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Ionic liquids (ILs) are a relatively new class of organic electrolytes composed of an organic cation and either an organic or inorganic anion, whose melting temperature falls around room-temperature. In the last 20 years, the toxicity of ILs towards cells and micro-organisms has been heavily investigated with the main aim to assess the risks associated with their potential use in (industrial) applications, and to develop strategies to design greener ILs. Toxicity, however, is synonym with affinity, and this has stimulated, in turn, a series of biophysical and chemical-physical investigations as well as few biochemical studies focused on the mechanisms of action (MoAs) of ILs, key step in the development of applications in bio-nanomedicine and bio-nanotechnology. This review has the intent to present an overview of the state of the art of the MoAs of ILs, which have been the focus of a limited number of studies but still sufficient enough to provide a first glimpse on the subject. The overall picture that emerges is quite intriguing and shows that ILs interact with cells in a variety of different mechanisms, including alteration of lipid distribution and cell membrane viscoelasticity, disruption of cell and nuclear membranes, mitochondrial permeabilization and dysfunction, generation of reactive oxygen species, chloroplast damage (in plants), alteration of transmembrane and cytoplasmatic proteins/enzyme functions, alteration of signaling pathways, and DNA fragmentation. Together with our earlier review work on the biophysics and chemical-physics of IL-cell membrane interactions (Biophys. Rev. 9:309, 2017), we hope that the present review, focused instead on the biochemical aspects, will stimulate a series of new investigations and discoveries in the still new and interdisciplinary field of “ILs, biomolecules, and cells.”

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Section: Mechanisms Of Action Of Ilsmentioning

confidence: 98%

“…Decrease in mitochondrial membrane potential has been observed in MDA-MB-231 cells incubated in [C 4 mim][Br] and [C 10 mim][BF 4 ] (Thamke et al 2019 ), see Fig. 13 .…”

Section: Mechanisms Of Action Of Ilsmentioning

confidence: 98%

“…13 Shift in the mitochondrial membrane potential of MDA-MB-231 cells treated with various ILs. Figure taken from Thamke et al ( 2019 ) and reproduced with permission from the publisher

Fig. 14 Representative pictures from live cell imaging of JC-1 stained RT112 cells a 1 h, b 2 h, and c 4 h after a treatment with 200 mM TPP1 IL.…”

Section: Mechanisms Of Action Of Ilsmentioning

confidence: 99%

“… Shift in the mitochondrial membrane potential of MDA-MB-231 cells treated with various ILs. Figure taken from Thamke et al ( 2019 ) and reproduced with permission from the publisher …”

Section: Mechanisms Of Action Of Ilsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Mechanisms of action of ionic liquids on living cells: the state of the art

2020

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Separation of phenolic compounds from oil mixtures by betaine‐based deep eutectic solvents

Xie

Liu

et al. 2020

Asia-Pacific J Chem Eng

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Separation of phenolic compounds from coal tar is of both economic and technological interest in the processing of coal tar. In this work, three deep eutectic solvents (DES) of betaine-glycerol, betaine-DL-lactic acid, and betaine-levulinic acid were formed and used to extract phenolic compounds from model coal tar. The effects of extraction time, temperature, initial phenol content, and mass ratio of DES to phenol on extraction were investigated. Then, the extraction and formation mechanisms of extractant were studied by the experimental and simulation methods. In addition, the neutral oil entrainment and the recycling of DES were also investigated. The results showed that phenol could be efficiently extracted in short time by three DES and the temperature had little effect on phenol extraction. Fourier transform infrared spectroscopy and deformation charge density indicated that the three DES are formed with hydrogen bonding interaction, the hydrogen bond acceptor and hydrogen bond donor of DES can form hydrogen bonding with phenol, respectively, and then synergistic extract phenol from model oil. The betaine-glycerol (Bet-Gly) was determined to be the preferable solvent with the extraction efficiency of 94.6% and 5.2% neutral oil entrainment under optimal conditions. It is an advantageous extractant in the separation of phenolic compounds from coal tar.

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Unlocking the Anticancer Potential of Ionic Liquids

Mohd Noor,

Elgharbawy,

Moniruzzaman

et al. 2023

ChemBioEng Reviews

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Despite advances in cancer treatment, many types of cancer still have high mortality rates, and the existing therapies can cause considerable side effects. Therefore, discovering new therapies, especially ones with fewer side effects, is desirable to improve the outcomes for cancer patients. Ionic liquids (ILs) have emerged as potential candidates for cancer treatment because of their particular physicochemical properties, which can be tailored for specific applications. In recent years, interest in exploring the potential of ILs in cancer treatment has been growing, and several studies have demonstrated the effectiveness of ILs in inhibiting cancer‐cell growth. This review provides insight into the anticancer potential of ILs, exploring the diverse applications and the underlying mechanisms behind the cytotoxicity toward cancer cells of ILs. Understanding the mechanisms behind the cytotoxicity of ILs can aid in the design and optimization of IL‐based cancer therapies. By focusing on specific pathways and targets, IL‐based cancer therapies may be developed that offer new possibilities for treating this devastating disease.

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In vitro toxicological evaluation of ionic liquids and development of effective bioremediation process for their removal

Cited by 31 publications

References 57 publications

Mechanisms of action of ionic liquids on living cells: the state of the art

Mechanisms of action of ionic liquids on living cells: the state of the art

Separation of phenolic compounds from oil mixtures by betaine‐based deep eutectic solvents

Unlocking the Anticancer Potential of Ionic Liquids

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