In vitro wound healing and cytotoxic effects of sinigrin–phytosome complex

Mazumder, Anisha; Dwivedi, Anupma; Preez, Jan L. du; Plessis, Jeanetta du

doi:10.1016/j.ijpharm.2015.12.027

Cited by 114 publications

(81 citation statements)

References 21 publications

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“…The main aim of the current study was to determine whether the phytosome complex enhanced the delivery of sinigrin into the skin layers by means of performing tape stripping on the skin after the 12 h of diffusion studies. Direct delivery to the wound site is desirable for therapeutic agents, such as sinigrin, which are involved in the wound‐healing process . Tape stripping results showed neither the control nor the sinigrin–phytosome complex delivered sinigrin into the epidermis–dermis.…”

Section: Resultsmentioning

confidence: 99%

“…It is well‐known that glucosinolates are broken down enzymatically by myrosinase, mainly to isothiocyanates, cyanides and thiocyanates, which are the main known bioactives and are generally attributed for its therapeutic benefits . In a recent study conducted in our laboratory, we have demonstrated the potential wound‐healing activity of sinigrin and its phytosome formulations . The aforementioned steered our interest in examining the in vitro topical delivery of sinigrin and its phytosome complex.…”

Section: Introductionmentioning

confidence: 99%

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In vitro skin permeation of sinigrin from its phytosome complex

Mazumder

Dwivedi

Fox

et al. 2016

Journal of Pharmacy and Pharmacology

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

In vitro skin permeation of sinigrin from its phytosome complex

Mazumder

Dwivedi

Fox

et al. 2016

Journal of Pharmacy and Pharmacology

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“…Once the DCM was evaporated 5 mL of n-hexane, was added to the thin film with stirring and left in a fume hood for complete removal of the solvent. After complete removal of n-hexane, the thin film was hydrated and sonicated for desired phytosomal complex [52]. c. Weigh accurate amount of phospholipid and polyphenolic extract.…”

Section: Preparation Techniques For Phytosomesmentioning

confidence: 99%

“…The study was carried out for in vitro wound healing capacity and the result is also appreciable as compare to sinigrin alone [61]. d. One research reported silymarin phytosomes with better antihepatotoxic activity as compare to silymarin alone and also having great role for the protection against B1 aflatoxin on broiler chicks [62]. e. The phytosomes from standardized extract of seeds of S. marianum have administered orally which is having great effect on foetus from maternally ingested alcohol [64].…”

Section: Advances In Phytosome Technologymentioning

confidence: 99%

A Review on Phytosomes: Novel Approach for Herbal Phytochemicals

Kumar

Singh

et al. 2017

Asian J Pharm Clin Res

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The poor oral bioavailability of polyphenolic compound can be enhanced through the incorporation of them into phospholipid based self-assembled delivery system, i.e. popularly known as phytosome. "Phyto" means plants and "some" resembles a covering around/or a structure. Phytosome is generally prepared by reacting one or two moles of polyphenolic phytoconstituents and phospholipid. It may be either in the ratio of 1:1 and 1:2. By using phytosomes, one can also achieve enhanced rate and extent of the passage of lipophilic herbal constituents across lipid membrane that explains its character as a carrier as well as acid labile herbal drugs could also be protected in gastrointestinal tract. There are number of products available in the market that contains phytosomal drug delivery system such as Ginkgo biloba, Silybum marianum, and Camellia sinensis. The present review describes an updated overview of preparation of phytosomes, advancement in phytosomes technology, various herbal drugs for which phytosomes have been used as a carrier, its commercial availability and applications.

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“…[38] Sinigrin, a glucosinolates was complexed with phosphatidylcholine and was compared with sinigrin for its wound healing property by Mazumder et al The wound healing and cytotoxic effect was analyzed on A-375 and HaCaT cells, where sinigrin phytosomes exhibit 71% wound closure than sinigrin alone after 42 h and this approach can be explored for wound treatment in case of cancer. [39] SM, phosholipid complex was prepared by Zeng et al and then, converted into microporous osmotic pump tablets (MPOP). The results reveal the dissolution rate for SM complex was higher than sylimarin alone and release rate for SMMPOP was 85% along with zero order releases profile, which represents its potential application for sustained release formulation.…”

Section: In Vivo Evaluationmentioning

confidence: 99%

Untitled

Nanavati¹

2017

AJP

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Novel drug delivery systems have gained significant importance because of their enhanced bioavailability and overall therapeutics. Hydrophilic nature and unique chemical structure of most of the therapeutically useful phytoconstituents which result in poor bioavailability and less absorption. The water soluble phytoconstituents have excellent bioactivity in vitro, but less or no action in vivo. Phytosome technology can overcome this problem in which the phytoconstituent is allowed to react with phospholipid. The phytoconstituent with poor lipid solubility on complexation into phytosome, can exhibit better pharmacodynamics and pharmacokinetics profile as compared to conventional herbal extract. Phytoconstituent must have good hydrophilicity which helps in dissolution in gastrointestinal fluid and hydrophobicity which helps cross lipid-rich cell membrane. Phytosome technology results in an intermolecular bonding between phospholipid, phosphatidylcholine and a single molecule of phytoconstituent. Phosphatidylcholine used in phytosome technology has also proven its clinical efficacy by acting as a carrier for fat and water miscible nutrients and natural digestive aid. Phytosomes can be used to treat acute and chronic liver failure due to improved pharmacological and pharmacokinetic property. In market, many products based on phytosome technology are available which include herbal extracts and phytochemicals with great therapeutic potential such as curcumin, ginkgo biloba, grape seed, silymarin, and many more. The present review highlights the method of preparation, properties, advantages, characterization, and applications.

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In vitro wound healing and cytotoxic effects of sinigrin–phytosome complex

Cited by 114 publications

References 21 publications

In vitro skin permeation of sinigrin from its phytosome complex

In vitro skin permeation of sinigrin from its phytosome complex

A Review on Phytosomes: Novel Approach for Herbal Phytochemicals

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