In vivo and in vitro evaluation of highly specific thiolate carrier group copper(II) and zinc(II) complexes on Ehrlich ascites carcinoma tumor model

Raman, Natarajan; Jeyamurugan, R.; Senthilkumar, R.; Balasubramanian, Ravikumar; Franzblau, Scott G.

doi:10.1016/j.ejmech.2010.09.004

Cited by 60 publications

(31 citation statements)

References 64 publications

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“…The first region, ranging from 221 to approximately 229 nm, is characteristic for the electronic inter ligand π→π* transitions [28], while the second characteristic wavelength, in the region of 281 nm to approximately 322 nm, is the second inter ligand n→π transition [29]. The third distinct region, ranging from 407 nm to approximately 498 nm, is the characteristic for the LMCT from the nitrogen atom to the transition metal center [30].…”

Section: Discussionmentioning

confidence: 99%

Acute Toxicity and Gastroprotection Studies of a New Schiff Base Derived Copper (II) Complex against Ethanol-Induced Acute Gastric Lesions in Rats

et al. 2012

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BackgroundCopper is an essential element in various metabolisms. The investigation was carried out to evaluate acute gastroprotective effects of the Copper (II) complex against ethanol-induced superficial hemorrhagic mucosal lesions in rats.Methodology/Principal FindingsRats were divided into 7 groups. Groups 1 and 2 were orally administered with Tween 20 (10% v/v). Group 3 was orally administered with 20 mg/kg omeprazole (10% Tween 20). Groups 4–7 received 10, 20, 40, and 80 mg/kg of the complex (10% Tween 20), respectively. Tween 20 (10% v/v) was given orally to group 1 and absolute ethanol was given orally to groups 2–7, respectively. Rats were sacrificed after 1 h. Group 2 exhibited severe superficial hemorrhagic mucosal lesions. Gastric wall mucus was significantly preserved by the pre-treatment complex. The results showed a significant increase in glutathione (GSH), superoxide dismutase (SOD), nitric oxide (NO), and Prostaglandin E2 (PGE2) activities and a decrease in malondialdehyde (MDA) level. Histology showed marked reduction of hemorrhagic mucosal lesions in groups 4–7. Immunohistochemical staining showed up-regulation of Hsp70 and down-regulation of Bax proteins. PAS staining of groups 4–7 showed intense stain uptake of gastric mucosa. The acute toxicity revealed the non-toxic nature of the compound.Conclusions/SignificanceThe gastroprotective effect of the Copper (II) complex may possibly be due to preservation of gastric wall mucus; increase in PGE2 synthesis; GSH, SOD, and NO up-regulation of Hsp70 protein; decrease in MDA level; and down-regulation of Bax protein.

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Section: Discussionmentioning

confidence: 99%

Acute Toxicity and Gastroprotection Studies of a New Schiff Base Derived Copper (II) Complex against Ethanol-Induced Acute Gastric Lesions in Rats

et al. 2012

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“…The role of Oxidant H 2 O 2 is to oxidise metal complex and releases OH free radical. This OHfree radical participates in the oxidation of the deoxyribose moiety, followed by hydrolytic cleavage of sugar phosphate backbone . The delivery of high concentration of metal ion to the helix, in locally generating oxygen or hydroxide radicals lead to an efficient DNA cleavage reaction.…”

Section: Resultsmentioning

confidence: 99%

Water Soluble Nickel – metformin ternary complexes: Thermal, DNA binding and molecular docking studies

Rajeshwari

Vasantha

Kumar

et al. 2019

Applied Organom Chemis

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The Nickel (II) complexes [Ni(Cl)2(metf)(o‐phen)] (1), [Ni(Cl)2(metf)(opda)] (2), [Ni(Cl)2(metf)(en)](3), [Ni(Cl)2(metf)(2,2'‐bipy)](4), (metf = metformin, o‐phen = ortho‐phenanthroline, opda = ortho‐phenylenediamine, en = ethylenediamine, 2–2′ bipy = 2–2′ bipyridyl) were synthesized and characterized using LC–MS, elemental analysis, molar conductance measurements, TGA‐DTA, IR spectroscopy, magnetic moment measurements and electronic spectroscopy. The central Ni2+ was found to be in octahedral geometry. The DNA interaction of these complexes have been studied by UV–visible absorption studies, fluorescence emission technique and viscosity measurement. The complexes showed absorption hyperchromism in UV–visible spectra with calf thymus DNA. The binding constants from UV–visible absorption studies were 7.42 × 104, 0.74 × 104, 3.19 × 104, 5.9 × 104 M−1 for 1, 2, 3 and 4, respectively and Stern‐Volmer quenching constants from fluorescence studies were 0.16, 0.41, 0.23, 0.18, respectively. Viscosity measurements revealed that the binding of the complexes with DNA could be surface binding, mainly due to groove binding. The highest DNA cleavage activity of the complexes is recorded for complex 1. The complexes were docked in to B‐DNA sequence, 5′(D*AP*CP*CP*GP*AP*CP* GP*TP*CP*GP*GP*T)‐3′ retrieved from protein data bank (PDB ID: 423D), using Discovery Studio 2.1 software. C Docker Intectraction energy of 1, 2, 3 and 4 complexes is 32.027, 31.427, 35.393 and 30.521 respectively. The highest docking score is seen for complex 3.

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“…Anti-tumor activity of the metal chelates is evaluated by the procedure described by Raman et al [37]. From their study, it is inferred that the Cu(II), Co(II) and Mn(II) complexes are effective antioxidants compared to others and thus we are interested to evaluate their in vivo antitumor activities.…”

Section: Anti-tumor Evaluationmentioning

confidence: 99%

DNA, the biopolymer as a target material for metalloinsertors: From chemistry to preclinical implications

Raman¹,

Selvaganapathy²,

Sudharsan³

2015

Materials Science and Engineering: C

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In vivo and in vitro evaluation of highly specific thiolate carrier group copper(II) and zinc(II) complexes on Ehrlich ascites carcinoma tumor model

Cited by 60 publications

References 64 publications

Acute Toxicity and Gastroprotection Studies of a New Schiff Base Derived Copper (II) Complex against Ethanol-Induced Acute Gastric Lesions in Rats

Acute Toxicity and Gastroprotection Studies of a New Schiff Base Derived Copper (II) Complex against Ethanol-Induced Acute Gastric Lesions in Rats

Water Soluble Nickel – metformin ternary complexes: Thermal, DNA binding and molecular docking studies

DNA, the biopolymer as a target material for metalloinsertors: From chemistry to preclinical implications

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