In vivo and in vitro study of the potential hazards of surgical smoke during cervical cancer treatment with an ultrasonic scalpel

Yan, Linzhi; Liu, Yi; Zhang, Jianan; Chen, Xin; Li, Jingwei; Zhu, Xueqiong

doi:10.1016/j.ygyno.2022.01.006

Cited by 6 publications

(7 citation statements)

References 45 publications

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“…Yan et al (2022) studied the chemical contents of surgical smoke collected during laparoscopic hysterectomy in 11 human cervical cancer patients. Bipolar electrocoagulation was also used.…”

Section: Resultsmentioning

confidence: 99%

“…Yan et al (2022) performed ultrasonic scalpel instrumentation of tumours induced in 24 mice with four human cervical cancer cells. Three cell lines were human papillomavirus (HPV) positive and one negative.…”

Section: Resultsmentioning

confidence: 99%

“…Yan et al (2022) instrumented tumours in mice induced with human cervical cell cancer cells, using the Harmonic Scalpel (Ethicon Endo-Surgery Inc). Microscopy of smoke samples with haematoxylin and eosin and Papanicolaou stains showed large quantities of cellular debris, several morphological intact epithelioid cells but no viable malignant cells.…”

Section: Resultsmentioning

confidence: 99%

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Chemical constituents, viable micro-organism and malignant cell content in ultrasonic scalpel plume: A literature review

Steel

Horridge

Awni

et al. 2023

Journal of Perioperative Practice

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Purpose: To identify all published data on the chemical, micro-organism and malignant cell contents of ultrasonic scalpel plume, if any, and on any clinical implications of the contents on patients and operating staff. Methods: Searches were conducted aiming to identify all published evidence on the chemical constituents, presence/absence of viable micro-organisms and malignant cells in ultrasonic scalpel plume. Attempts were made to source unpublished industry data. Results: There is evidence from human and in vitro studies of the presence of a range of harmful, and some human carcinogenic, chemicals within ultrasonic plume, mostly at very low concentrations. Any clinical relevance of this has not been studied. There is evidence from experimental studies of the presence of hepatitis virus, human coronavirus and human papillomavirus material within ultrasonic plume. Any clinical effect of this has not been studied. There is conflicting evidence from combined in vitro and mouse model studies of the presence of viable malignant cells within ultrasonic plume. Any clinical relevance of this has also not been studied. Conclusion: Overall, relatively little research into the plume has been published, and further study is required to more clearly delineate any potential risk to patients, surgeons and other theatre staff. Current safety recommendations are discussed.

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“…Yan et al (2022) studied the chemical contents of surgical smoke collected during laparoscopic hysterectomy in 11 human cervical cancer patients. Bipolar electrocoagulation was also used.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Chemical constituents, viable micro-organism and malignant cell content in ultrasonic scalpel plume: A literature review

Steel

Horridge

Awni

et al. 2023

Journal of Perioperative Practice

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“…HPV-DNA has been proven to be distinctly isolatable from the surgical fumes produced during these treatments, indicating that healthcare professionals are passively exposed to HPVs during procedures to treat afflicted patients by particles found in the ambient air. 2 , 10 Moreover, it has been found that the viral particles containing HPV-DNAisolated from the surgical fumes are capable of infecting HPV-negative cervical cancer cell lines. 10 It becomes then imperative that healthcare providers in positions vulnerable to exposure to such surgical fumes, and thus HPV-DNA molecules, mitigate their risk of susceptibility to becoming infected by a type of HPV.…”

Section: Introductionmentioning

confidence: 99%

“… 2 , 10 Moreover, it has been found that the viral particles containing HPV-DNAisolated from the surgical fumes are capable of infecting HPV-negative cervical cancer cell lines. 10 It becomes then imperative that healthcare providers in positions vulnerable to exposure to such surgical fumes, and thus HPV-DNA molecules, mitigate their risk of susceptibility to becoming infected by a type of HPV. 2 , 11 …”

Section: Introductionmentioning

confidence: 99%

Human papillomavirus and occupational exposure: The need for vaccine provision for healthcare providers

Afsar,

Hossain,

Islam

et al. 2024

Human Vaccines & Immunotherapeutics

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To probe the understanding of healthcare providers regarding occupational exposure to human papillomavirus and their knowledge about human papillomavirus vaccination in relation to the American Society for Colposcopy and Cervical Pathology (ASCCP) recommendations. In this cross-sectional study, the healthcare providers at Mayo Clinic Arizona, Florida, and Minnesota were delivered an electronic survey. The survey was completed by 349 healthcare providers, with one respondent excluded for inconsistent entry. The mean age of respondents was 42.7 ± 10.9, and of those, 68% were female and 32% were male. Of the unvaccinated respondents, 43.3% were ≤ 45 y of age (eligible for vaccination), while those vaccinated formed 41% of the respondents. Healthcare providers are highly concerned about their cancer safety, as shown by their awareness of occupational human papillomavirus hazards and broad knowledge about vaccine efficacy. The use of personal protective equipment varied widely, including eyewear, double gloving, procedural face mask, N95 face mask, and/or nothing. Human papillomavirus and cancer risk was clearly perceived by healthcare providers. For professions, pairwise comparisons revealed that nurse practitioners, physician assistants, certified registered nurse anesthetists, and allied healthcare providers had lower scores than medical doctors. Despite the high level of understanding among healthcare providers of occupational human papillomavirus exposure, only a few of them knew of the recommendations of the ASCPP for vaccination of healthcare providers treating human papillomavirus-related diseases. In such cases, most of those surveyed embraced vaccination, which was considered 100% safe by medical doctors and allied health professionals.

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Knowledge mapping of surgical smoke from 2003 to 2022: a bibliometric analysis

Li,

Geng,

et al. 2024

Surg Endosc

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Purpose The purpose of this study is to identify and characterize the literature on surgical smoke, visualize the data and sketch a certain trending outline. Methods In the Web of Science Core Collection (WoSCC), all the data were acquired from January 1st 2003 to December 31st 2022. VOSviewer and CiteSpace were employed to visualize data, based on publications, bibliographic coupling, co-citation, or co-authorship relations. Microsoft Excel 2019 was used to comb and categorize all the statistics. Result A total 363 of journal papers were retrieved. The publication number was in a slow but steady growth between 2003 and 2019, followed by a sharp surge in 2020, and then the publication kept in a productive way. Surgical endoscopy and other interventional techniques was the most active journal on surgical smoke. USA played an important role among all the countries/regions. There were 1847 authors for these 363 papers, among whom 44 authors published more than three articles on surgical smoke. “Surgical smoke”, “covid-19” and “surgery” were the top 3 appeared keywords, while the latest hot-spot keywords were “COVID-19”, “virus”, “transmission”, “exposure” and “risk”. There were 1105 co-cited references and 3786 links appeared in all 363 articles. Among them, 38 references are cited more than 10 times. The most co-cited article was “Detecting hepatitis B virus in surgical smoke emitted during laparoscopic surgery.” Based on the titles of references and calculated by CiteSpace, the top 3 cluster trend network are “laparoscopic surgery”, “COVID-19 pandemic” and “surgical smoke”. Conclusion According to bibliometric analysis, the research on surgical smoke has been drawing attention of more scholars in the world. Increasing number of countries or regions added in this field, and among them, USA, Italy, and China has been playing important roles, however, more wide and intense cooperation is still in expectation.

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In vivo and in vitro study of the potential hazards of surgical smoke during cervical cancer treatment with an ultrasonic scalpel

Cited by 6 publications

References 45 publications

Chemical constituents, viable micro-organism and malignant cell content in ultrasonic scalpel plume: A literature review

Chemical constituents, viable micro-organism and malignant cell content in ultrasonic scalpel plume: A literature review

Human papillomavirus and occupational exposure: The need for vaccine provision for healthcare providers

Knowledge mapping of surgical smoke from 2003 to 2022: a bibliometric analysis

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