In Vivo and in Vitro Evaluation of Tephrosia Calophylla for Anti-Diabetic Properties

Ck, Ramesh; A, Prameela Rani

doi:10.22159/ijpps.2018v10i6.25551

Cited by 7 publications

(1 citation statement)

References 26 publications

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“…The DM is a metabolic, multifactorial and devitalizing disease with increasing occurrence in the entire world which may leads to various complications such as multi organ failures, peripheral neuropathy, retinopathy, nephropathy, hyperlipidemia and various cardiovascular disorders 15, 16 . One of the novel therapeutic approach for management of diabetes mellitus is enhancement of glucose by peripheral tissues is very important mechanism.…”

Section: Discussionmentioning

confidence: 99%

The ethanol extract of Euphorbia hirta exhibits in vitro antidiabetic potentials by sensitization of the insulin

Shwetha,

Ramesh,

Pinkey

et al. 2023

J. Drug Delivery Ther.

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The objective of current investigation was to assess the mechanism of action of Euphorbia hirta for its antidiabetic properties. Materials &Methods: The authenticated leaves of plant Euphorbia hirta were dried and powdered. The powdered drug was defatted with petroleum ether and subjected to ethanol extraction. The ethanol extract of Euphorbia hirta was subjected to preliminary phytochemical investigation. The glucose up takes by rat hemi-diaphragm (skeletal muscle) model was also used evaluate potentials of the ethanol extract of Euphorbia hirta to enhance utilization of the blood glucose by peripheral tissues. The overnight fasted albino rat was sacrificed and dissected to hemidiaphragm. Weighed quantity of skeletal muscle was incubated with glucose in Tyrode solution for 30 mins at 37oC and the amount of glucose utilized by the tissue was determined. Results: The ethanol extract of Euphorbia hirta significantly increased the glucose utilization by skeletal muscle which its shows potency to sensitize the insulin. Conclusion: The results of the presents investigation recommends that, one of the mechanisms of ethanol extract of Euphorbia hirta for antidiabetic activity is reduction of insulin resistance.

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Section: Discussionmentioning

confidence: 99%

The ethanol extract of Euphorbia hirta exhibits in vitro antidiabetic potentials by sensitization of the insulin

Shwetha,

Ramesh,

Pinkey

et al. 2023

J. Drug Delivery Ther.

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Hepatoprotective Effect of Ethanolic Extract of Whole Plant of <i>Tephrosia barberi</i> J. R. Drumm. in Paracetamol Induced Hepatotoxicity in Rats

Sameemabegum,

Thilagavathi,

Kumarnallasivan

et al. 2024

JNR

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Background: Tephrosia barberi J. R. Drumm is a novel endemic perennial herb belonging to the Fabaceae family. Aim: To investigate the hepatoprotective activity of the whole plant of T. barberi. Methods: Preliminary phytochemical testing and GCMS analysis were done for the ethanolic extract of T. barberi. Initially, acute toxicity experiments were carried out in which five groups of rats (n=3) were administered with 0.5% carboxymethyl cellulose (normal control), ethanolic extract of T. barberi orally (5, 50, 300 and 2000 mg/kg b.w.) for 14 days daily, there was no mortality observed for 24 hr. For the assessment of the hepatoprotective potential, ethanolic extracts of T. barberi (200mg/kg low dose and 400mg/kg high dose) and silymarin (100mg/kg, employed as the reference standard), distilled water (normal control, paracetamol control) was given orally to five groups of rats (n=6) over seven days. All animals were given paracetamol on the fifth day, following the administration of standard and extracts, except for those in normal control. To assess the levels of serum enzymes, proteins, antioxidant indicators, and histopathological analyses, the rats were sacrificed and blood samples, liver homogenate, and liver sections were taken. Results: Rats fed with T. barberi ethanol extract (400mg/kg/day) and silymarin, a standard drug (100mg/kg/day) treated groups had significantly elevated liver serum enzymes such as alanine phosphatase, aspartate aminotransferase, alanine transaminase, total protein and total bilirubin than the intoxicated rats (p<0.01to p<0.001). Furthermore, the effect of antioxidant parameters (GSH, CAT, and SOD) on hepatic tissue showed that ethanol extract of T. barberi (high dose, 400mg/kg) produced improved hepatic function than toxic control rat and exhibited significant action compared to standard drug. Conclusion: The current research findings strongly indicate that T. barberi has promising hepatoprotective potential due to the presence of flavonoids and phenolic compounds.

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Detailed Pharmacognostical Standardisation and Phytochemical Analysis of Whole Plant of <i>Tephrosia barber</i> — An Endemic Novel Medicinal Plant

Nallasivan,

Sameemabegum

2024

JNR

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Background: Tephrosia barberi J. R. Drumm. is a perennial herb belonging to the Fabaceae family. Aim: The present research work is focused on carrying out the pharmacognostic standardisation and primary phytochemical analysis of the whole plant of T. barberi. Methods: The morphology, microscopy, powder microscopy, quantitative analysis of leaf constants, fluorescence analysis and physio-chemical parameters were included in the pharmacognostical work for the whole plant followed WHO prescribed quality control methods. The primary phytochemical analysis is carried out for powder with different solvent extracts using standard procedure. Results: The study reveals that the microscopical character of the whole plant of T. barberi includes the presence of cork, phloem fibres, xylem vessels, starch grains, tracheids, unicellular warty trichomes, anamocytic type of stomata and prismatic type calcium oxalate crystal sheath. The total ash, acid insoluble ash, water soluble ash value, sulphated ash, and loss on drying were quantified as physiochemical parameters, which were observed by 3%, 1%, 2%, 5% and 8%, respectively, using T. barberi dry powder. Under daylight, long and short UV, extracts of the whole plant and with various reagents were seen as various fluorescent reflection shades, which showed satisfactory results. Additionally, the primary phytochemical analysis of different extracts of T. barberi showed the presence of alkaloids, flavonoids, steroidal glycosides, polyphenols and terpenoids. Conclusion: All these findings ensured that the whole plant profile for T. barberi could be accomplished, which may provide proper identification and probable to minimise the adulteration of other plant species. Furthermore, the primary phytochemical screening study would be useful to carry out the isolation of phytoconstituents and their therapeutic potency in future.

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In Vivo and in Vitro Evaluation of Tephrosia Calophylla for Anti-Diabetic Properties

Cited by 7 publications

References 26 publications

The ethanol extract of Euphorbia hirta exhibits in vitro antidiabetic potentials by sensitization of the insulin

The ethanol extract of Euphorbia hirta exhibits in vitro antidiabetic potentials by sensitization of the insulin

Hepatoprotective Effect of Ethanolic Extract of Whole Plant of <i>Tephrosia barberi</i> J. R. Drumm. in Paracetamol Induced Hepatotoxicity in Rats

Detailed Pharmacognostical Standardisation and Phytochemical Analysis of Whole Plant of <i>Tephrosia barber</i> — An Endemic Novel Medicinal Plant

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