In Vivo Comparison Between Optical Coherence Tomography and Intravascular Ultrasound for Detecting Small Degrees of In-Stent Neointima After Stent Implantation

Abstract

Optical coherence tomography detects smaller degrees of ISN more accurately than IVUS and might be a useful method for identifying neointimal coverage of stent struts after DES implantation.

Delayed Coverage in Malapposed and Side-Branch Struts With Respect to Well-Apposed Struts in Drug-Eluting Stents

“…Although biologically plausible and intuitively accepted by the scientific community, this approach cannot be fully supported by current evidence. OCT coverage correlates with histological neointimal healing and endothelialization after stenting in animal models, [33][34][35] but its sensitivity and specificity in human atherosclerotic vessels are still unknown. OCT is not able to detect thin Values are presented as count (%).…”

Optical Coherence Tomography and Histopathology Assessment After Implantation of First- and Second-Generation Drug-Eluting Stents in a Porcine Coronary Model

“…16, 17 OCT also allows identification of neointimal tissue morphologic patterns. [18][19][20][21] In humans, histological validation of coronary OCT for evaluating the coverage of stent struts with intimal tissue has not been systematically conducted due to the insufficient availability of autopsy samples.…”

Management of Antiplatelet Therapy in Patients With Coronary Artery Disease Requiring Cardiac and Noncardiac Surgery

“…Optical coherence tomography is a high-resolution intravascular imaging modality based on infrared light emission, which, because of its resolution in the range of 10 to 15 μm, has emerged as a sensitive tool to assess the presence of stent strut coverage. 137,138 For this reason, optical coherence tomography has the potential to provide evidence to guide the duration of antiplatelet treatment in stented patients who need to prematurely discontinue DAPT. 139 This hypothesis, however, has not yet been prospectively tested.…”