In vivo diode dosimetry vs. computerized tomography and digitally reconstructed radiographs for critical organ dose calculation in high-dose-rate brachytherapy of cervical cancer

Hassouna, A.; Bahadur, Yasir A.; Constantinescu, C.; Sayed, M. El; Naseem, Hussain; Naga, A.

doi:10.1016/j.brachy.2011.03.004

Cited by 7 publications

(3 citation statements)

References 14 publications

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“…Ionizing radiation is largely employed in the industrial and medical areas. This makes radiation dose assessment essential for medical treatment and diagnosis, such as cancer radiation therapy, , tomography, radiography, , and fluoroscopy, as well as for radiological protection and personal dosimetry . Therefore, the development of adequate radiation sensors that comply with each specific application is of utmost importance.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Gold/Alanine Nanocomposites with Potential Properties for Medical Application as Radiation Sensors

Guidelli

Ramos

Zaniquelli

et al. 2012

ACS Appl. Mater. Interfaces

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Radiation dose assessment is essential for several medical treatments and diagnostic procedures. In this context, nanotechnology has been used in the development of improved radiation sensors, with higher sensitivity as well as smaller sizes and energy dependence. This paper deals with the synthesis and characterization of gold/alanine nanocomposites with varying mass percentage of gold, for application as radiation sensors. Alanine is an excellent stabilizing agent for gold nanoparticles because the size of the nanoparticles does not augment with increasing mass percentage of gold, as evidenced by UV-vis spectroscopy, dynamic light scattering, and transmission electron microscopy. X-ray diffraction patterns suggest that the alanine crystalline orientation undergoes alterations upon the addition of gold nanoparticles. Fourier transform infrared spectroscopy indicates that there is interaction between the gold nanoparticles and the amine group of the alanine molecules, which may be the reason for the enhanced stability of the nanocomposite. The application of the nanocomposites as radiation detectors was evaluated by the electron spin resonance technique. The sensitivity is improved almost 3 times in the case of the nanocomposite containing 3% (w/w) gold, so it can be easily tuned by changing the amount of gold nanoparticles in the nanocomposites, without the size of the nanoparticles influencing the radiation absorption. In conclusion, the featured properties, such as homogeneity, nanoparticle size stability, and enhanced sensitivity, make these nanocomposites potential candidates for the construction of small-sized radiation sensors with tunable sensitivity for application in several medical procedures.

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Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Gold/Alanine Nanocomposites with Potential Properties for Medical Application as Radiation Sensors

Guidelli

Ramos

Zaniquelli

et al. 2012

ACS Appl. Mater. Interfaces

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show abstract

“…In vivo dosimetry methods have been proposed for high dose rate (HDR), [3][4][5][6][7][8][9][10][11][12][13] and LDR, [14][15][16][17] brachytherapy using a variety of dosimeters; e.g., TLDs, diodes, and plastic scintillation detectors. All these detectors lack accuracy due to the uncertainty of the detector position, 4,9 which is crucial in brachytherapy.…”

Section: Introductionmentioning

confidence: 99%

In vivo dosimetry for gynaecological brachytherapy using a novel position sensitive radiation detector: Feasibility study

et al. 2012

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In this study, the authors proposed a dosimetry procedure, based on the novel RADPOS system, to accurately determine the position of the radiation dosimeter with respect to the applicator. The authors found that it is possible to monitor the delivered dose in a point and compare it to the predetermined dose. This allows in principle the detection of problems such as bladder motion/filling or source mispositioning. Further clinical investigation is warranted.

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“…It is possible to conduct radiation dosimetry by many techniques such as thermoluminescence (TL) 1-2 , optically stimulated luminescence(OSL) [3][4] , electron spin resonance (ESR) spectroscopy [5][6][7][8][9] , and radioluminescence (RL) [10][11] , among others. Because fulfilling each specific treatment and/or diagnosis modality, such as radiotherapy [12][13] , radiology [14][15] , and personal dosimetry 16 , is desirable, the search for new materials with improved properties has been intense.…”

Section: Introductionmentioning

confidence: 99%

Potential application of metal nanoparticles for dosimetric systems: Concepts and perspectives

Guidelli

Baffa

2014

AIP Conference Proceedings

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Abstract. Metallic nanoparticles increase the delivered dose and consequently enhance tissue radio sensitization during radiation therapy of cancer. The Dose Enhancement Factor (DEF) corresponds to the ratio between the dose deposited on a tissue containing nanoparticles, and the dose deposited on a tissue without nanoparticles. In this sense, we have used electron spin resonance spectroscopy (ESR) to investigate how silver and gold nanoparticles affect the dose deposition in alanine dosimeters, which act as a surrogate of soft tissue. Besides optimizing radiation absorption by the dosimeter, the optical properties of these metal nanoparticles could also improve light emission from materials employed as radiation detectors. Therefore, we have also examined how the plasmonic properties of noble metal nanoparticles could enhance radiation detection using optically stimulated luminescence (OSL) dosimetry. This work will show results on how the use of gold and silver nanoparticles are beneficial for the ESR and OSL dosimetric techniques, and will describe the difficulties we have been facing, the challenges to overcome, and the perspectives.

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In vivo diode dosimetry vs. computerized tomography and digitally reconstructed radiographs for critical organ dose calculation in high-dose-rate brachytherapy of cervical cancer

Cited by 7 publications

References 14 publications

Synthesis and Characterization of Gold/Alanine Nanocomposites with Potential Properties for Medical Application as Radiation Sensors

Synthesis and Characterization of Gold/Alanine Nanocomposites with Potential Properties for Medical Application as Radiation Sensors

In vivo dosimetry for gynaecological brachytherapy using a novel position sensitive radiation detector: Feasibility study

Potential application of metal nanoparticles for dosimetric systems: Concepts and perspectives

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