In Vivo Dynamic Metabolic Changes After Transplantation of Induced Pluripotent Stem Cells for Ischemic Injury

Wu, Shuang; Zhu, Yuankai; Líu, Hao; Tang, Ling; Du, Ruili; Shen, Yehua; Jin, Feng; Zhang, Kai; Xu, Caiyun; Shou-hong, Zhang; Chen, Yao; Song, Fahuan; Zhu, Yi; Gu, Weizhong; Liang, Ping; Carrió, Ignasi; Zhang, Hong; Tian, Mei

doi:10.2967/jnumed.115.171124

Cited by 8 publications

(3 citation statements)

References 13 publications

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“…This continual dilatation and remodeling in end-diastolic volume may represent a compensatory mechanism in response to increased wall stress ( Grossman, 1980 ). In previous studies using iPSC-CMs from different species, the changes in LV function varied from study to study ( Citro et al., 2014 , Wu et al., 2016 ). In our current study, both NHP and human iPSC-CMs showed similar potency in improving LV function and attenuation in chamber dilatation.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Non-human Primate versus Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Treatment of Myocardial Infarction

et al. 2018

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SummaryNon-human primates (NHPs) can serve as a human-like model to study cell therapy using induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs). However, whether the efficacy of NHP and human iPSC-CMs is mechanistically similar remains unknown. To examine this, RNU rats received intramyocardial injection of 1 × 107 NHP or human iPSC-CMs or the same number of respective fibroblasts or PBS control (n = 9–14/group) at 4 days after 60-min coronary artery occlusion-reperfusion. Cardiac function and left ventricular remodeling were similarly improved in both iPSC-CM-treated groups. To mimic the ischemic environment in the infarcted heart, both cultured NHP and human iPSC-CMs underwent 24-hr hypoxia in vitro. Both cells and media were collected, and similarities in transcriptomic as well as metabolomic profiles were noted between both groups. In conclusion, both NHP and human iPSC-CMs confer similar cardioprotection in a rodent myocardial infarction model through relatively similar mechanisms via promotion of cell survival, angiogenesis, and inhibition of hypertrophy and fibrosis.

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Section: Discussionmentioning

confidence: 99%

Comparison of Non-human Primate versus Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Treatment of Myocardial Infarction

et al. 2018

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“…In recent years, with the development of PET technology, the pathophysiological changes of many major neurological diseases, including Alzheimer’s disease, Parkinson’s disease, and psychiatric disorders, have been explored with the help of PET molecular imaging [ 83 – 85 ]. Similarly, for some heart diseases such as ischemic infarction, PET can sensitively detect the infarcts and evaluate the severity of the lesion, thus playing a key role in the diagnosis, evaluation, and treatment [ 86 , 87 ].…”

Section: The Molecular Imaging-based Multiscale Pathology Visualizationmentioning

confidence: 99%

Transpathology: molecular imaging-based pathology

Tian

Jin

et al. 2021

Eur J Nucl Med Mol Imaging

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Pathology is the medical specialty concerned with the study of the disease nature and causes, playing a key role in bridging basic researches and clinical medicine. In the course of development, pathology has significantly expanded our understanding of disease, and exerted enormous impact on the management of patients. However, challenges facing pathology, the inherent invasiveness of pathological practice and the persistent concerns on the sample representativeness, constitute its limitations. Molecular imaging is a noninvasive technique to visualize, characterize, and measure biological processes at the molecular level in living subjects. With the continuous development of equipment and probes, molecular imaging has enabled an increasingly precise evaluation of pathophysiological changes. A new pathophysiology visualization system based on molecular imaging is forming and shows the great potential to reform the pathological practice. Several improvements in “trans-,” including trans-scale, transparency, and translation, would be driven by this new kind of pathological practice. Pathological changes could be evaluated in a trans-scale imaging mode; tissues could be transparentized to better present the underlying pathophysiological information; and the translational processes of basic research to the clinical practice would be better facilitated. Thus, transpathology would greatly facilitate in deciphering the pathophysiological events in a multiscale perspective, and supporting the precision medicine in the future.

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“…The efficacy of ESCderived cardiomyocytes in repairing myocardium was established in a primate myocardial infarction model [70]. Moreover, ESC-CMs transplanted into the infarcted heart can survive and improve cardiac functions [71]. Despite the early promises, clinical translation of the hESCs is jeopardized by two major shortcomings, the potential formation of teratomas resulting from remaining undifferentiated cells and ethical issues that in many countries prevent the employment of human embryos to derive cells for therapy [8].…”

Section: Human Pluripotent Stem Cellsmentioning

confidence: 99%

Cells and Materials for Cardiac Repair and Regeneration

Al-Hejailan

Garoffolo

Raveendran

et al. 2023

JCM

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After more than 20 years following the introduction of regenerative medicine to address the problem of cardiac diseases, still questions arise as to the best cell types and materials to use to obtain effective clinical translation. Now that it is definitively clear that the heart does not have a consistent reservoir of stem cells that could give rise to new myocytes, and that there are cells that could contribute, at most, with their pro-angiogenic or immunomodulatory potential, there is fierce debate on what will emerge as the winning strategy. In this regard, new developments in somatic cells’ reprogramming, material science and cell biophysics may be of help, not only for protecting the heart from the deleterious consequences of aging, ischemia and metabolic disorders, but also to boost an endogenous regeneration potential that seems to be lost in the adulthood of the human heart.

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In Vivo Dynamic Metabolic Changes After Transplantation of Induced Pluripotent Stem Cells for Ischemic Injury

Cited by 8 publications

References 13 publications

Comparison of Non-human Primate versus Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Treatment of Myocardial Infarction

Comparison of Non-human Primate versus Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Treatment of Myocardial Infarction

Transpathology: molecular imaging-based pathology

Cells and Materials for Cardiac Repair and Regeneration

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