In vivo evaluation of interactions between biphasic calcium phosphate (BCP)-niobium pentoxide (Nb2O5) nanocomposite and tissues using a rat critical-size calvarial defect model

Kiyochi, Helio de Jesus; Candido, Aline Gabriela; Bonadio, T. G. M.; Cruz, José Adauto da; Baesso, Mauro Luciano; Weinand, W. R.; Hernandes, Luzmarina

doi:10.1007/s10856-020-06414-5

Cited by 12 publications

(11 citation statements)

References 42 publications

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“…To remove the organic substance and grease attached to their surface, fish discards were washed with distilled water [91], ethanol, and deionized water for 1 h [92], 2 h [93,94], or 3 h [32] or with boiling water [13,86,88,89,[95][96][97] for 1 h [90,98,99] or 48 h [84] in an over pressurized water jet [90] and treated with 1% [98] or 5% (w/v) [91] sodium hydroxide solution and washed with ultra-pure water [98] or with 0.1 M HCl and washed with distilled water [91].…”

Section: Pre-treatment Of Fish Discardsmentioning

confidence: 99%

“…After the cleaning step, all fish discards were dried at room temperature (RT) in air [91,92,95,98] for 1 h [86,88,89] or in an oven [90] at 40 °C [97], at 55-70 °C up to 48 h [93,94], or 60 °C [91,96] for 20-30 min [32] or 72 h [99]. Next, the sterile fish discards were crushed,…”

Section: Pre-treatment Of Fish Discardsmentioning

confidence: 99%

“…The combination of natural CaPs, in general, and BCP, in particular, with other materials, in terms of biocompatible alloys, ceramics, and polymers, represents an alternative way towards the development of new biomaterials with improved performance and mechanical responses with the aim to mimic those of natural bones and tissues [95,105,110].…”

Section: From Fish Discards To Powder Preparationmentioning

confidence: 99%

“…Nb 2 O 5 was chosen due to its biocompatibility and high resistance to corrosion [111]. NbBCP nanocomposite was pressed as discs (8-mm diameter, 1-mm thickness) and sintered in air atmosphere at 1000 • C for 1 h. After sintering, the discs were ultrasonically washed with acetone, water, and alcohol and autoclaved [95].…”

Section: From Fish Discards To Powder Preparationmentioning

confidence: 99%

“…In case of NbBCP, the obtained grains had a rod-like shape, with sizes in the (1.0-2.5) μm range. In addition, SEM analysis evidenced the existence of a less porous microstructure for NbBCP [95]. On the other hand, Bonadio et al [110] compared the morphologies for PVDF and BCP-PVDF samples before and after immersion in SBF (for seven days).…”

Section: Morphological Characteristicsmentioning

confidence: 99%

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A Review on Biphasic Calcium Phosphate Materials Derived from Fish Discards

2021

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This review summarizes the results reported on the production of biphasic calcium phosphate (BCP) materials derived from fish wastes (i.e., heads, bones, skins, and viscera), known as fish discards, and offers an in-depth discussion on their promising potential for various applications in many fields, especially the biomedical one. Thus, considerable scientific and technological efforts were recently focused on the capability of these sustainable materials to be transformed into economically attractive and highly valuable by-products. As a consequence of using these wastes, plenty of beneficial social effects, with both economic and environmental impact, will arise. In the biomedical field, there is a strong and continuous interest for the development of innovative solutions for healthcare improvement using alternative materials of biogenic origin. Thus, the orthopedic field has witnessed a significant development due to an increased demand for a large variety of implants, grafts, and/or scaffolds. This is mainly due to the increase of life expectancy and higher frequency of bone-associated injuries and diseases. As a consequence, the domain of bone-tissue engineering has expanded to be able to address a plethora of bone-related traumas and to deliver a viable and efficient substitute to allografts or autografts by combining bioactive materials and cells for bone-tissue ingrowth. Among biomaterials, calcium phosphate (CaP)-based bio-ceramics are widely used in medicine, in particular in orthopedics and dentistry, due to their excellent bioactive, osteoconductive, and osteointegrative characteristics. Recently, BCP materials (synthetic or natural), a class of CaP, which consist of a mixture of two phases, hydroxyapatite (HA) and beta tricalcium phosphate (β-TCP), in different concentrations, gained increased attention due to their superior overall performances as compared to single-phase formulations. Moreover, the exploitation of BCP materials from by-products of fish industry was reported to be a safe, cheap, and simple procedure. In the dedicated literature, there are many reviews on synthetic HA, β-TCP, or BCP materials, but to the best of our knowledge, this is the first collection of results on the effects of processing conditions on the morphological, compositional, structural, mechanical, and biological properties of the fish discard-derived BCPs along with the tailoring of their features for various applications.

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