In vivo micro–computed tomography evaluation of BoneCeramic grafted alveolar defects during orthodontic tooth movement

Ru, Nan; Liu, Sean Shih-Yao; Bai, Yuxing; Li, Song; Liu, Yunfeng; Zhou, Guanjun

doi:10.2319/112315-797.1

Cited by 3 publications

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“…Table 2 describes the main characteristics of the studies included in this scoping review. The studies were published between 1996 [ 9 ] and 2022 [ 10 ] and were mostly developed in China ( n = 13) [ 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 ], which was followed by Japan ( n = 3) [ 24 , 25 , 26 ], Germany ( n = 3) [ 10 , 27 , 28 ], Israel ( n = 2) [ 7 , 29 ], Korea ( n = 2) [ 30 , 31 ], Italy ( n = 1) [ 32 ], Brazil ( n = 1) [ 33 ], Bangladesh ( n = 1) [ 9 ], Sweden ( n = 1) [ 34 ], Turkey ( n = 1) [ 35 ], Egypt ( n = 1) [ 36 ], and the United States of America ( n = 1) [ 37 ].…”

Section: Resultsmentioning

confidence: 99%

“…Dogs were employed in most experiments ( n = 12) [ 9 , 21 , 24 , 25 , 30 , 34 ]. Seven studies incorporated humans as the subjects of analysis [ 15 , 23 , 28 , 32 , 35 , 36 , 37 ], while six studies involved rats [ 10 , 16 , 17 , 18 , 19 , 27 ], two studies used mice [ 7 , 29 ], two studies utilised rabbits [ 12 , 21 ], and the sample comprised minipigs in one study [ 33 ].…”

Section: Resultsmentioning

confidence: 99%

“…The nature of the defect varied among the selected studies. Sixteen studies addressed extraction socket grafts [ 7 , 9 , 11 , 12 , 14 , 16 , 17 , 18 , 22 , 24 , 25 , 28 , 29 , 30 , 33 , 34 ], seven focused on periodontal sockets [ 13 , 20 , 23 , 31 , 32 , 36 , 37 ], and an additional seven dealt with alveolar clefts [ 10 , 15 , 19 , 21 , 26 , 27 , 35 ]. Concerning their location, 21 articles examined defects in the upper jaw, 3 in the lower jaw [ 12 , 22 , 34 ], and 5 in both bones [ 14 , 20 , 28 , 31 , 33 ].…”

Section: Resultsmentioning

confidence: 99%

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Biological Effects of Orthodontic Tooth Movement on the Periodontium in Regenerated Bone Defects: A Scoping Review

Verdecchia,

Suárez-Fernández,

Miquel

et al. 2024

Dentistry Journal

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The aim of this scoping review is to analyse the biological effects of the orthodontic tooth movement (OTM) in areas with bone defects that are undergoing regeneration using different types of regenerative materials and techniques. The electronic research was performed on four databases as follows: PubMed, Scopus, EMBASE, and Web of Science. Data were extracted according to publication information, study design, sample characteristics, parameters of OTM, biological repercussions on the periodontium complex, methods of analysis, and conclusions. A total of thirty studies were included in the final review. In twenty-two studies, the most widely adopted grafting materials were alloplastics. In most studies, the orthodontic force used was 10 or 100 g, and the timing of application ranged from immediate to 6 months after grafting surgery. Twenty-four studies showed an increase in osteogenesis; in five studies, the clinical attachment level (CAL) increased; in five others, the probing pocket depth (PPD) decreased; in sixteen studies, there was root resorption of a different magnitude. Though the effects of OTM on the periodontium in the grafted areas were positive, the outcomes should be interpreted with caution as future preclinical and clinical studies are needed to extrapolate more valid conclusions.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Biological Effects of Orthodontic Tooth Movement on the Periodontium in Regenerated Bone Defects: A Scoping Review

Verdecchia,

Suárez-Fernández,

Miquel

et al. 2024

Dentistry Journal

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“…In corresponding animal research, various rat models have been described as focusing the bone responses at recipient sites [1][2][3][5][6][7][8]31,32 and different areas have been established to enable critical-size bone defects in rat models 10 . These regions can also be viewed as potential donor sites for grafting non-vascular allografts in rats, www.nature.com/scientificreports/ which could be of interest in cases of jaw reconstruction.…”

Section: Discussionmentioning

confidence: 99%

“…Different rodent models have been established in animal research for the treatment of clefts focusing the bone responses in grafted sites [1][2][3][4][5][6][7][8] . These alveolar cleft repairs can be performed using various dental materials that include natural bone materials like autografts, allografts or xenografts as well as synthetic bone substitutes such as bioceramics, polymers or biocomposites 9 .…”

mentioning

confidence: 99%

Ischial tuberosity: new donor site for bone grafts in animal cleft research

Möhlhenrich

Kniha

Magnuska

et al. 2020

Sci Rep

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In the context of cleft repair in animal research in rat models, different areas can be used for bone grafting. The aim of the present study was to present the tuberosity of the ischium as a new donor site and to evaluate its quality in relation to an artificial alveolar cleft. Four weeks after creating experimental alveolar clefts in seven Wistar rats, the repair was performed in the now twelve-week-old male animals using bone blocks grafted from the ischial tuberosity. Two days before surgery and two as well as twenty-eight days after surgery, microCT scans were performed, and the grafted bone blocks were analyzed regarding height, width, thickness, and volume. Additionally, bone mineral density (BMD) and bone volume fraction (BV/TV) were measured in the repaired cleft. The mean bone volume of the graft was about 19.77 ± 7.77mm3. Immediately after jaw reconstruction the BMD and BV/TV were about 0.54 ± 0.05 g/cm3 and 54.9 ± 5.07% for the transplant and about 1.13 ± 0.08 g/cm3 and 94.5 ± 3.70%, respectively, for the surrounding bone. Four weeks later the BMD and BV/TV were about 0.57 ± 0.13 g/cm3 and 56.60 ± 13.70% for the transplant and about 11.17 ± 0.07 g/cm3 and 97.50 ± 2.15%, respectively, for the surrounding bone. A hip fracture was found in four of the animals after surgery. The ischial tuberosity offers large bone blocks, which are sufficient for cleft repair in the rat model. However, the bone quality regarding BMD and BV/TV is less compared with the surrounding bone of the alveolar cleft, even after a period of 4 weeks, despite recognizable renovation processes.

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Study of bone remodeling in corticotomy‐assisted orthodontic tooth movement in rats

Zhou

Zhang

2019

J of Cellular Biochemistry

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The goal of this study was to determine the structure change of the alveolar bone and the expression of a group of bone remodeling‐related factors. Sixty healthy male Wistar rats were randomly divided into three groups. Selective alveolar decortication (SAD), tooth movement (TM), and “combined therapy” (SAD+TM) was performed in group I, II, and III, respectively. On days 0, 7, 14, 21, and 42, a Micro‐CT scan was performed on the maxillary alveolar bone and tooth. In addition, on days 0, 7, 14, 21, 28, and 42, some of the rats were killed by cervical dislocation and tissues were harvested. Analysis of scan data revealed a significant decrease in bone density of the alveolar bone at 14 days post‐surgery, and increased at 42 days post‐surgery to a level higher than that before the surgery. Microarray and bioinformatics analysis were performed to explore gene expression profile in three groups (SAD, TM, and SAD+TM), and a large number of differentially expressed genes were identified. In addition, real‐time polymerase chain reaction was performed to determine the expression of bone remodeling‐related factors. The expression of osteoblast‐related cytokines, including osteopontin, bone sialoprotein, and osteocalcin, and osteoclast regulators macrophage‐colony stimulating factor (M‐CSF) and RANKL (activator of nuclear factor KB receptor ligand) were increased in group III, suggesting that there was increased bone synthesis and activation of bone absorption. Moreover, group III had a unique alveolar bone remodeling pattern: RANKL and osteoprotegerin‐promoted alveolar remodeling. In conclusion, during the early stage of orthodontic tooth movement, corticotomy can accelerate the movement of teeth, modulate the state of bone metabolism, and activate osteogenesis and osteoclast, which support the theory of regional acceleratory phenomenon.

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In vivo micro–computed tomography evaluation of BoneCeramic grafted alveolar defects during orthodontic tooth movement

Abstract: Ahead of Print article withdrawn by publisher.

Cited by 3 publications

References 0 publications

Biological Effects of Orthodontic Tooth Movement on the Periodontium in Regenerated Bone Defects: A Scoping Review

Biological Effects of Orthodontic Tooth Movement on the Periodontium in Regenerated Bone Defects: A Scoping Review

Ischial tuberosity: new donor site for bone grafts in animal cleft research

Study of bone remodeling in corticotomy‐assisted orthodontic tooth movement in rats

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