In vivo microdialysis?A technique for analysis of chemical activators of muscle pain

Microdialysis of neuropeptide Y in human muscle tissue

“…Molecules in the extracellular space diffuse into the perfusate, flow back between the membrane and the inner cannula and are collected at the outlet of the probe (Lindefors et al, 1987). In muscle tissue microdialysis has mainly been used to study the local metabolism but there are only few studies available where intramuscular microdialysis has been used to study pain or microcirculatory mediators (Ernberg et al, 1999;Graven-Nielsen et al, 1997;Hedenberg-Magnusson et al, 2001;McArdle et al, 1999).…”