In vivo MR imaging tracking of magnetic iron oxide nanoparticle labeled, engineered, autologous bone marrow mesenchymal stem cells following intra-articular injection

Jing, Xu-hong; Yang, Liu; Duan, Xiaojun; Xie, Bing; Chen, Wei; Li, Zhong; Tan, Huiwen

doi:10.1016/j.jbspin.2007.09.013

Cited by 137 publications

(117 citation statements)

References 27 publications

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“…MSCs were isolated and cultured by a method previously described [13]. The cells of the second passages were harvested for seeding in collagen type II hydrogel (Engineering Research Center for Biomaterials, Sichuan University, China).…”

Section: Msc Isolation and In Vitro Proliferationmentioning

confidence: 99%

Bone marrow-derived mesenchymal stem cells versus bone marrow nucleated cells in the treatment of chondral defects

Zhang

Wang

Chen

et al. 2011

International Orthopaedics (SICOT)

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Section: Msc Isolation and In Vitro Proliferationmentioning

confidence: 99%

Bone marrow-derived mesenchymal stem cells versus bone marrow nucleated cells in the treatment of chondral defects

Zhang

Wang

Chen

et al. 2011

International Orthopaedics (SICOT)

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“…[1][2][3][4][5] Because of their exceptional properties, researchers have attempted to use such nanoparticles for tumor inhibition, 6 dual-functional probes, 7 and antibacterial agents. 6 Although different biomedical applications for various iron oxide MNPs (such as drug delivery, 7 cellular labeling/cell separation, 8 tissue repair, 9 magnetic resonance imaging, 9 and magnetic hyperthermia) 10 have been studied by several research groups, it is essential to determine their toxicity in animal models. Mahmoudi et al studied the cytotoxicity of polyvinyl alcohol-coated magnetic nanoparticles in mouse fibroblast cells and a human leukemia cell line, with results highlighting that at appropriate concentrations, MNPs are not toxic.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, and antimicrobial activity of an ampicillin-conjugated magnetic nanoantibiotic for medical applications

Hussein‐Al‐Ali¹,

Zowalaty²,

Hussein³

et al. 2014

IJN

104

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Because of their magnetic properties, magnetic nanoparticles (MNPs) have numerous diverse biomedical applications. In addition, because of their ability to penetrate bacteria and biofilms, nanoantimicrobial agents have become increasingly popular for the control of infectious diseases. Here, MNPs were prepared through an iron salt coprecipitation method in an alkaline medium, followed by a chitosan coating step (CS-coated MNPs); finally, the MNPs were loaded with ampicillin (amp) to form an amp-CS-MNP nanocomposite. Both the MNPs and amp-CS-MNPs were subsequently characterized and evaluated for their antibacterial activity. X-ray diffraction results showed that the MNPs and nanocomposites were composed of pure magnetite. Fourier transform infrared spectra and thermogravimetric data for the MNPs, CS-coated MNPs, and amp-CS-MNP nanocomposite were compared, which confirmed the CS coating on the MNPs and the amp-loaded nanocomposite. Magnetization curves showed that both the MNPs and the amp-CS-MNP nanocomposites were superparamagnetic, with saturation magnetizations at 80.1 and 26.6 emu g −1 , respectively. Amp was loaded at 8.3%. Drug release was also studied, and the total release equilibrium for amp from the amp-CS-MNPs was 100% over 400 minutes. In addition, the antimicrobial activity of the amp-CS-MNP nanocomposite was determined using agar diffusion and growth inhibition assays against Gram-positive bacteria and Gram-negative bacteria, as well as Candida albicans . The minimum inhibitory concentration of the amp-CS-MNP nanocomposite was determined against bacteria including Mycobacterium tuberculosis . The synthesized nanocomposites exhibited antibacterial and antifungal properties, as well as antimycobacterial effects. Thus, this study introduces a novel β-lactam antibacterial-based nanocomposite that can decrease fungus activity on demand for numerous medical applications.

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“…Jing et al, 34 using the Feridex-protamine sulfate complex as the SPION, as well as transfection agents, tracked mesenchymal stem cells in the articular cartilage within the knee joints of rabbits. The study showed that there were no changes in the viability, proliferation, or differentiation of the labeled stem cells in comparison to the non-labeled cells when examined at a concentration of 25 µM.…”

Section: In Vivo Animal Studiesmentioning

confidence: 99%

Stem cell tracking using iron oxide nanoparticles

Bull¹,

Madani²,

Sheth³

et al. 2014

IJN

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Superparamagnetic iron oxide nanoparticles (SPIONs) are an exciting advancement in the field of nanotechnology. They expand the possibilities of noninvasive analysis and have many useful properties, making them potential candidates for numerous novel applications. Notably, they have been shown that they can be tracked by magnetic resonance imaging (MRI) and are capable of conjugation with various cell types, including stem cells. In-depth research has been undertaken to establish these benefits, so that a deeper level of understanding of stem cell migratory pathways and differentiation, tumor migration, and improved drug delivery can be achieved. Stem cells have the ability to treat and cure many debilitating diseases with limited side effects, but a main problem that arises is in the noninvasive tracking and analysis of these stem cells. Recently, researchers have acknowledged the use of SPIONs for this purpose and have set out to establish suitable protocols for coating and attachment, so as to bring MRI tracking of SPION-labeled stem cells into common practice. This review paper explains the manner in which SPIONs are produced, conjugated, and tracked using MRI, as well as a discussion on their limitations. A concise summary of recently researched magnetic particle coatings is provided, and the effects of SPIONs on stem cells are evaluated, while animal and human studies investigating the role of SPIONs in stem cell tracking will be explored.

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In vivo MR imaging tracking of magnetic iron oxide nanoparticle labeled, engineered, autologous bone marrow mesenchymal stem cells following intra-articular injection

Cited by 137 publications

References 27 publications

Bone marrow-derived mesenchymal stem cells versus bone marrow nucleated cells in the treatment of chondral defects

Bone marrow-derived mesenchymal stem cells versus bone marrow nucleated cells in the treatment of chondral defects

Synthesis, characterization, and antimicrobial activity of an ampicillin-conjugated magnetic nanoantibiotic for medical applications

Stem cell tracking using iron oxide nanoparticles

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