In vivo oxygen consumption and hemoglobin levels in human thyroarytenoid muscle

Abstract

Objectives/Hypothesis Visible light spectroscopy (VLS) is the technology behind the Food and Drug Administration–approved TSTAT device that is used to monitor tissue oxygen (StO2) and relative total hemoglobin (rtHb) levels by measuring reflected visible light. The purpose of this novel, pilot study was to determine if VLS is a reliable and valid method of measuring StO2 and rtHb levels in the human thyroarytenoid/lateral cricoarytenoid (TA-LCA) muscle complex, thus providing information about vocal fold muscle physiology. Study Design Pre-test/post-test with mulitple baselines and two conditions. Methods VLS measurements were taken at baseline, during exercise, and following recovery on six subjects using both noncontact channel-port endoscope (endo-probe) and laryngeal electromyography (LEMG) needle-guided techniques. Results The average baseline StO2 was 69% (standard deviation [SD] = 3.6%) for the LEMG-guided probe and was 71.5% (SD = 2.8%) for the endo-probe. During phonation, the StO2 for the LEMG-guided probe dropped to 59% (SD = 7%; P = .04). Mean rtHb measured by the LEMG probe rose from a baseline of 144 µM (SD = 165 µM) to 214 µM (SD = 166 µM, P = .34) during phonation and back to 149 µM (SD = 139 µM, P = .85) after recovery. Mean rtHb as measured using the endo-probe at baseline and after recovery was 104 µM (SD = 30 µM, P = .76). Conclusions VLS can be used to measure changes in StO2 and rtHb levels pre- and postexercise in the human TA-LCA muscle complex.

Tipos de fibras de los músculos intrínsecos laríngeos de seres humanos: una revisión de la literatura

“…Clínicamente, los resultados obtenidos permiten dirigir con mayor precisión la carga durante la ejercitación o en el entrenamiento de los músculos fonatorios. Esto se puede llevar a cabo gracias al entendimiento de las distintas vías energéticas que predominan durante la producción de la voz, donde (según los últimos hallazgos), habría mayor preponderancia aeróbica, oxidativa o mitocondrial (Lin et al, 2017;Nanjundeswaran et al, 2017;Tellis et al, 2011). En este caso, las fibras tipo I, IIA y las cadenas lentas son las que se activarían preferentemente para realizar la actividad muscular propia de la fonación (Johnson & Sandage, 2019).…”

Consecuencias laringoscópicas, electroglotográficas, acústicas y sintomatológicas producidas por la sobrecarga vocal en mujeres con voces sanas y no entrenadas

“…Este tipo de particularidades remarca la relevancia del concepto resistencia laríngea, donde la condición muscular permite enfrentar (según su grado de desarrollo) de peor o mejor forma la exigencia de la tarea, confirmando así, que la sobrecarga y sus expresiones están condicionadas por la capacidad aeróbica y anaeróbica que presentan, principalmente, los músculos de los pliegues vocales (Tellis, Rosen, Carroll, Fierro, & Sciote, 2011).…”

Exercise Science and the Vocalist

“…The actual bioenergetic requirements for voice use is largely theoretical at the time of this writing and the metabolic profile for the intrinsic laryngeal muscles is not well understood in vivo. Tellis et al 8 used visible light spectroscopy in vivo to monitor tissue oxygen and relative total hemoglobin in the thyroarytenoid/lateral cricoarytenoid (TA-LCA) complex. A decrease in oxygen was observed during a sustained voicing task.…”