In vivo sub-acute physiological stress induced by Sumithion on some aspects of oxidative metabolism in the fresh water crab

Bhagyalakshmi, A.; Reddy, P. Sreenivasula; Ramamurthi, R.

doi:10.1007/bf00283202

Cited by 8 publications

(6 citation statements)

References 11 publications

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“…CAT is an antioxidant enzyme that acts on the conversion of H 2 O 2 into water and oxygen. 67 Together with the observed GPx induction at lower concentrations, this suggests that a pesticide-induced generation of free oxygen radicals took place in these crabs. [68][69][70] The bell-shape trend is a typical response of detoxication and antioxidant biomarkers to contaminants.…”

Section: Discussionmentioning

confidence: 70%

“…21 In organisms acclimated to historical pollution, the energetic requirements imposed by the exposure appear to be met through the aerobic production pathway, with no relevant contribution from the anaerobic route. Bhagyalakshmi et al 67 also reported alteration of these enzyme activities upon crustacean exposure to this OP. LDH induction and IDH inhibition were found in the freshwater crab Oziotelphusa 1946 | Environ.…”

Section: Discussionmentioning

confidence: 90%

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Involvement of the antioxidant system in differential sensitivity of Carcinus maenas to fenitrothion exposure

Rodrigues

Gravato

Guimarães

2013

Environ. Sci.: Processes Impacts

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Carcinus maenas is an invertebrate with worldwide distribution and high ability to adapt to different environments, which is frequently used in environmental monitoring. Despite this, it is not clear how historical exposure to moderate contamination may influence sensitivity to further chemical stress in this important decapod species. This study investigated differential responses to organophosphate fenitrothion of C. maenas from a moderately contaminated estuary and a low impacted one, using in vitro and in vivo biomarker assays. To clarify potential differences in sensitivity, a biochemical characterisation of muscle cholinesterases was first performed. The results indicated acetylcholinesterase (AChE) as the main form present in C. maenas muscle. Exposure assays revealed that crabs from the moderately contaminated site were less sensitive to fenitrothion showing lower AChE inhibition than those from the low impacted site. Other biomarker changes detected in these animals were: increased anaerobic metabolism (muscle lactate dehydrogenase), enhanced phase II biotransformation (glutathione S-transferases in the digestive gland) and antioxidant defences (i.e., activities of glutathione reductase, glutathione peroxidase and catalase, and levels of total glutathiones in the digestive gland). Altogether, the results pointed out a role for the glutathione redox system towards tolerance to fenitrothion exposure.

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Section: Discussionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 90%

Involvement of the antioxidant system in differential sensitivity of Carcinus maenas to fenitrothion exposure

Rodrigues

Gravato

Guimarães

2013

Environ. Sci.: Processes Impacts

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“…Metabolic changes, also observed in seawater and freshwater crustaceans exposed to OP insecticides, create widespread disturbances in general physiological processes such as enzymatic activities [20e22], oxidative metabolism [20], and oxygen consumption [23,24]. However, the effect on the immune response and resistance to pathogens in prawns under OP stress are of primary concern.…”

Section: Introductionmentioning

confidence: 99%

Trichlorfon, an organophosphorus insecticide, depresses the immune responses and resistance to Lactococcus garvieae of the giant freshwater prawn Macrobrachium rosenbergii

Chang

Lee

Liu

et al. 2006

Fish & Shellfish Immunology

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“…Other studies, in general, have found conflicting results using this enzyme: Toxicant exposure resulted in an increased [24,25], decreased [26], or unaffected [27,28] ICDH activity. Our 48-h observations suggest that the increased energy demand in exposed daphnids was met by this highly efficient energy-producing pathway.…”

Section: Discussionmentioning

confidence: 95%

“…Our 48-h observations suggest that the increased energy demand in exposed daphnids was met by this highly efficient energy-producing pathway. Other studies, in general, have found conflicting results using this enzyme: Toxicant exposure resulted in an increased [24,25], decreased [26], or unaffected [27,28] ICDH activity. Based on the results shown in Figure 2, one could conclude that increased ICDH activity is correlated with decreased population performance.…”

Section: Discussionmentioning

confidence: 95%

A multivariate biomarker‐based model predicting population‐level responses of Daphnia magna

Coen

Janssen

2003

Enviro Toxic and Chemistry

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A multivariate model is proposed relating short-term biomarker measurements in Daphnia magna to chronic effects (21-d exposure) occurring at the population level (time to death, mean brood size, mean total young per female, intrinsic rate of natural increase, net reproductive rate, and growth). The results of the short-term exposure (48 h-96 h) to eight model toxicants (cadmium, chromium, mercury, tributyl tin, linear alkylsulfonic acid, sodium pentachlorophenolate, lindane, and 2,4-dichlorophenoxyacetic acid) on the following biomarkers were used for the multivariate model: digestive enzymes (amylase, cellulase, beta-galactosidase, trypsin, and esterase), enzymes of the intermediary metabolism (glycogen phosphorylase, glucose-6-phosphate dehydrogenase, pyruvate kinase, lactate dehydrogenase, and isocitrate dehydrogenase), cellular energy allocation (CEA) (protein, carbohydrate, and lipid content and electron transport activity), and DNA damage and antioxidative stress activity. Using partial least squares to latent structures (PLS), a two-component model was obtained with R2 of 0.68 and a Q2 value of 0.60 based on the combined analysis of a limited number of the 48- and 96-h biomarker responses. For the individual population-level responses, the R2 values varied from 0.66 to 0.77 and the Q2 values from 0.52 to 0.69. Energy-related biomarkers (cellular energy allocation, lipid contents, anaerobic metabolic activity--pyruvate kinase, and lactate dehydrogenase), combined with parameters related to oxidative stress (catalase) and DNA damage measured after 48 and 96 h of exposure, were able to predict long-term effects at higher levels of biological organization.

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In vivo sub-acute physiological stress induced by Sumithion on some aspects of oxidative metabolism in the fresh water crab

Cited by 8 publications

References 11 publications

Involvement of the antioxidant system in differential sensitivity of Carcinus maenas to fenitrothion exposure

Involvement of the antioxidant system in differential sensitivity of Carcinus maenas to fenitrothion exposure

Trichlorfon, an organophosphorus insecticide, depresses the immune responses and resistance to Lactococcus garvieae of the giant freshwater prawn Macrobrachium rosenbergii

A multivariate biomarker‐based model predicting population‐level responses of Daphnia magna

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