In Vivo Toxicity of Aqueous and Ethanolic Extracts of Twelve Antimalarial Plants

Rostand, Offoumou M’Baï; Rolland, Kipré Gueyraud; Dieudonné, Silué Kigbafori; Degaulle, Kouamé Kouadio; Koffi, N.; Joseph, Djaman Allico; Noël, Zirihi Guédé

doi:10.21276/irjps.2018.5.1.3

IRJPS

2018

DOI: 10.21276/irjps.2018.5.1.3

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In Vivo Toxicity of Aqueous and Ethanolic Extracts of Twelve Antimalarial Plants

Offoumou M’Baï Rostand¹,

Kipré Gueyraud Rolland²,

Silué Kigbafori Dieudonné³

et al.

Abstract: The practice of traditional medicine by plants is very popular among African populations including those of the Department of Agboville (South-East of Côte d'Ivoire) against various diseases, particularly malaria. The objective of this study is to verify by subacute toxicity the safety of the aqueous and ethanolic extracts of twelve medicinal plants from this Department in order to justify their traditional uses. The methodology used is OECD guideline 423, which is to determine in which dose range a substance … Show more

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Cited by 7 publications

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Antibiotic Resistance of Streptococcus Pneumoniae, Neisseria Meningitidis, Haemophilus Influenzae and Staphylococcus Aureus in Morocco, National Data: Meta- Analysis.

Al-Selwi

Barkat

2023

Biomed. Pharmacol. J.

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Bacterial resistance to antibiotics has a very important role because it constitutes a threat to human health, especially immunocompromised people and children, this phenomenon can lead to difficulty or even the impossibility of treating certain infections. A meta-analysis from studies in Morocco on bacteria resistant to antibiotics over the last nine years and interest of bacterial: S. pneumoniae, N. meningitidis, H. influenzae and S. aureus, also the evolution their resistance. Total 654 articles in databases (206, 162, 134, and 152 articles found in: Elsevier, PubMed, Google Scholar, and other engines, respectively). For the bacteria in which we were interested, the prevalence of resistance increases with the years. Indeed, S. pneumoniae, N. meningitidis and H. influenzae, prevalence in 2012, 2016 and 2018 was respectively around (13%, 9.7%, 5.4%), (48%, 24%, 8%) and (29%, 33%, 8%). The evolution of the resistance of S. pneumoniae, was impacted by the introduction of the vaccine, indeed, the rate of its resistance to the antibiotic erythromycin before vaccination was 76% but after the introduction of the vaccine it decreased to 61%, while the incidence of pneumonia was 17.7%, and after vaccination it decreased to 10.2%. Also, the resistance of S. pneumoniae to penicillin G increased from 2.7% in 2011 to 100% in 2020. For N. meningitidis, resistance to penicillin G increased from 11.1% to 24% between 2012 and 2019. About of H. Influenzae for Bactrim, fluoroquinolones and tetracycline (16%, 4.8%, 2.5%), S.aureus resistance increases significantly. From 2016 to 2018, the resistance of S. aureus (Penicillin G 92%, ciprofloxacin 16.5%, erythromycin 14.6%).

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Antibiotic Resistance of Streptococcus Pneumoniae, Neisseria Meningitidis, Haemophilus Influenzae and Staphylococcus Aureus in Morocco, National Data: Meta- Analysis.

Al-Selwi

Barkat

2023

Biomed. Pharmacol. J.

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Exploitations cacaoyères et pratiques culturales au sein d’un espace domanial : cas de la forêt classée du Haut-Sassandra (FCHS), Côte d’Ivoire

Timité

Yao²,

Kpangui³

et al. 2019

J.Anim.Plant Sci.

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1 RÉSUMÉ La forêt classée du Haut-Sassandra (FCHS) était l’une des forêts classées la mieux conservée avant la crise politico-militaire en Côte d’Ivoire. Cependant, elle a été massivement infiltrée par de nombreuses populations pendant la décennie de crises qu’a connue la Côte d’Ivoire de 2002 à 2011. La présente étude a pour objectif d’identifier les caractéristiques sociodémographiques des populations infiltrées et les pratiques culturales utilisées lors de la mise en place des plantations cacaoyères au sein de la FCHS. Pour y arriver, des enquêtes ont été réalisées de décembre 2017 à janvier 2018 auprès de 82 personnes sur environ une centaine de cacaoculteurs infiltrés dont les parcelles sont contenues dans le bloc 25 de la FCHS. Les enquêtes ont été suivies par des observations directes dans ces cacaoyères. Les résultats ont montré que 95,1 % des cacaoculteurs infiltrés sont des ressortissants Burkinabè, résidant dans les villages et campements riverains du bloc 25 de la FCHS. Ils sont majoritairement des jeunes cacaoculteurs ayant de petites plantations, généralement moins de 6 ha. La mise en place des plantations a débuté pendant la crise et s’est poursuivie après la période de conflits de 2011. Ces plantations ont été installées après défriche de la forêt par semis direct des fèves en utilisant un matériel végétal non sélectionné. Les fréquences de désherbage et de traitement phytosanitaire sont de deux à trois passages par an. Par ailleurs, la non maitrise des bonnes pratiques culturales cacaoyères, associée au manque d’encadrement (du fait de leur présence illégale au sein du domaine protégé de la FCHS), affecte le rendement annuel des plantations cacaoyères qui est d’environ 154 kg/ha contre 395 kg/ha au niveau national. Cocoa farms and farming practices within a federal area: the case of the classified forest of Haut-Sassandra (FCHS) (Côte d'Ivoire) SUMMARY The Haut-Sassandra classified forest (FCHS) was one of the best preserved classified forests before the politico-military crisis in Côte d'Ivoire. However, it was massively infiltrated by many populations during the decade of crises in Côte d'Ivoire from 2002 to 2011. The objective of this study is to identify the socio-demographic characteristics of the infiltrated populations and the farming practices used when setting up cocoa plantations within the FCHS. To achieve this, surveys were conducted from December 2017 to January 2018 among 82 people out of approximately 100 infiltrated cocoa farmers whose plots are contained in FCHS Block 25. The surveys were followed by direct observations in these cocoa farms. The results showed that 95.1% of infiltrated cocoa farmers are Burkinabe nationals, residing in villages and camps along the banks of FCHS Block 25. They are mainly young cocoa farmers with small plantations, generally less than 6 ha. The establishment of plantations began during the crisis and continued after the 2011 conflict period. These plantations were installed after clearing the forest by direct seeding of the beans using unselected plant material. The frequency of weeding and phytosanitary treatment is two to three times a year. In addition, the lack of good cocoa farming practices, combined with the lack of supervision (due to their illegal presence within the FCHS protected area), affects the annual yield of cocoa plantations, which is around 154 kg/ha compared to 395 kg/ha at national level.

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Plantes utilisées dans le traitement traditionnel de l’infertilité féminine dans le département de Dabakala (Côte d’Ivoire)

Romuald¹

2019

J.Anim.Plant Sci.

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1 RESUME Le but de cette étude est de recenser et documenter les plantes médicinales utilisées traditionnellement contre l’infertilité féminine par les matrones (accoucheuses traditionnelles) dans le département de Dabakala (Côte d’Ivoire). Ainsi une enquête par questionnaire a été menée auprès de 71 matrones du département de Dabakala. Les résultats de cette enquête ont indiqué que 25 espèces reparties entre 23 genres et 18 familles sont utilisées par les matrones pour soigner divers cas d’infertilité. Les familles les plus représentées sont les Annonaceae et les Solanaceae. Parmi les espèces citées, Heliotropium indicum (Boraginaceae), Parkia biglobosa (Fabaceae), Xylopia aethiopica (Annonaceae), Vitellaria paradoxa (Sapotaceae) et Kigelia africana (Bignoniaceae) sont les plus recommandées. Les valeurs de VAUs de ces espèces varient de 0,42 à 0,24. Ces résultats constituent une base de données pour les études ultérieures visant à évaluer les potentialités biologiques et chimiques de ces plantes. ABSTRACT The purpose of this study is to identify and document medicinal plants traditionally used by matrons (traditional midwives) against female infertility in the department of Dabakala (Côte d’Ivoire). A questionnaire survey therefore was conducted on 71 matrons in Dabakala department. The results of this survey showed that 25 species distributed among 23 types and 18 families are used by the matrones to treat various cases of infertility. The most represented families (groups of espece) are Annonaceae and Solanaceae. Among the mentioned species, Heliotropium indicum (Boraginaceae), Parkia biglobosa (Fabaceae), Xylopia aethiopica (Annonaceae), Vitellaria paradoxa (Sapotaceae) and Kigelia africana (Bignoniaceae) are the most recommended. The Use Agreement Value (VAU-valeur d'accord d'utilisation) (VAU) of these species vary from 0.42 to 0.24. These results provide a database for subsequent studies to evaluate the biological and chemical potential of these plants.

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In Vivo Toxicity of Aqueous and Ethanolic Extracts of Twelve Antimalarial Plants

Cited by 7 publications

References 1 publication

Antibiotic Resistance of Streptococcus Pneumoniae, Neisseria Meningitidis, Haemophilus Influenzae and Staphylococcus Aureus in Morocco, National Data: Meta- Analysis.

Antibiotic Resistance of Streptococcus Pneumoniae, Neisseria Meningitidis, Haemophilus Influenzae and Staphylococcus Aureus in Morocco, National Data: Meta- Analysis.

Exploitations cacaoyères et pratiques culturales au sein d’un espace domanial : cas de la forêt classée du Haut-Sassandra (FCHS), Côte d’Ivoire

Plantes utilisées dans le traitement traditionnel de l’infertilité féminine dans le département de Dabakala (Côte d’Ivoire)

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