In vivo voxel based morphometry: Detection of increased hippocampal volume and decreased glutamate levels in exercising mice

Biedermann, Sarah V.; Fuß, Johannes; Zheng, Lei; Sartorius, Alexander; Falfán-Melgoza, Claudia; Demirakça, Traute; Gass, Peter; Ende, Gabriele; Weber‐Fahr, Wolfgang

doi:10.1016/j.neuroimage.2012.04.010

Cited by 110 publications

(89 citation statements)

References 34 publications

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“…Thus, Biedermann et al 35 and our results show volume changes and glutamatergic metabolism in the right hippocampus. Despite differences in the direction of volumetric changes, the results of both studies point to changes of the right hippocampus.…”

Section: Spectroscopic Resultssupporting

confidence: 79%

Hippocampal Structure, Metabolism, and Inflammatory Response after a 6-Week Intense Aerobic Exercise in Healthy Young Adults: A Controlled Trial

Wagner

Herbsleb

Cruz

et al. 2015

J Cereb Blood Flow Metab

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Interventional studies suggest that changes in physical fitness affect brain function and structure. We studied the influence of high intensity physical exercise on hippocampal volume and metabolism in 17 young healthy male adults during a 6-week exercise program compared with matched controls. We further aimed to relate these changes to hypothesized changes in exercisedinduced brain-derived neurotrophic factor (BDNF), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNF-α). We show profound improvement of physical fitness in most subjects and a positive correlation between the degree of fitness improvement and increased BDNF levels. We unexpectedly observed an average volume decrease of about 2%, which was restricted to right hippocampal subfields CA2/3, subiculum, and dentate gyrus and which correlated with fitness improvement and increased BDNF levels negatively. This result indicates that mainly those subjects who did not benefit from the exercise program show decreased hippocampal volume, reduced BDNF levels, and increased TNF-α concentrations. While spectroscopy results do not indicate any neuronal loss (unchanged N-acetylaspartate levels) decreased glutamate-glutamine levels were observed in the right anterior hippocampus in the exercise group only. Responder characteristics need to be studied in more detail. Our results point to an important role of the inflammatory response after exercise on changes in hippocampal structure.

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Section: Spectroscopic Resultssupporting

confidence: 79%

Hippocampal Structure, Metabolism, and Inflammatory Response after a 6-Week Intense Aerobic Exercise in Healthy Young Adults: A Controlled Trial

Wagner

Herbsleb

Cruz

et al. 2015

J Cereb Blood Flow Metab

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“…Areas with significant differences in grey matter volume induced by wheel-running in a murine hippocampus [62]. The colour scale shows the T value of the statistical test.…”

Section: Translational Structural Methodsmentioning

confidence: 99%

Advantages and Challenges of Small Animal Magnetic Resonance Imaging as a Translational Tool

Hoyer¹,

Gass

Weber‐Fahr

et al. 2014

Neuropsychobiology

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The utilization of magnetic resonance imaging (MRI) methods in rodent models of psychiatric disorders provides considerable benefits for the identification of disease-associated brain circuits and metabolic changes. In this review, we discuss advantages and challenges of animal MRI and provide an overview of the major structural (voxel-based morphometry and diffusion tensor imaging) and functional approaches [resting-state functional MRI (rs-fMRI), MR spectroscopy (MRS), regional cerebral blood volume measurement and arterial spin labelling] that are applied in animal MRI research. The review mainly focuses on rs-fMRI and MRS. Finally, we take a look at some recent developments and refinements in the field.

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“…At the level of correlations, diffusion properties changes in white matter were correlated with myelin markers 67 ; diffusion in grey matter correlated with astrocytic and synaptic markers 65 . Volumetric changes similarly correlated with synaptic markers, in particular GAP43, an axonal growth cone indicator 64,68 , dendritic spine counts 69 , and glutamate concentration 70 . Establishing more causal connections between cellular and mesoscopic changes is just beginning; irradiation, for example, has been shown to stop both neurogenesis and exercise-related increases hippocampal volume 71 .…”

Section: Applications Of Structural Mrimentioning

confidence: 81%

Studying neuroanatomy using MRI

et al. 2017

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The study of neuroanatomy using imaging enables key insights into how our brains function, are shaped by genes and environment, and change with development, aging, and disease. Developments in MRI acquisition, image processing, and data modelling have been key to these advances. However, MRI provides an indirect measurement of the biological signals we aim to investigate. Thus, artifacts and key questions of correct interpretation can confound the readouts provided by anatomical MRI. In this review we provide an overview of the methods for measuring macro-and mesoscopic structure and inferring microstructural properties; we also describe key artefacts and confounds that can lead to incorrect conclusions. Ultimately, we believe that, though methods need to improve and caution is required in its interpretation, structural MRI continues to have great promise in furthering our understanding of how the brain works.

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In vivo voxel based morphometry: Detection of increased hippocampal volume and decreased glutamate levels in exercising mice

Cited by 110 publications

References 34 publications

Hippocampal Structure, Metabolism, and Inflammatory Response after a 6-Week Intense Aerobic Exercise in Healthy Young Adults: A Controlled Trial

Hippocampal Structure, Metabolism, and Inflammatory Response after a 6-Week Intense Aerobic Exercise in Healthy Young Adults: A Controlled Trial

Advantages and Challenges of Small Animal Magnetic Resonance Imaging as a Translational Tool

Studying neuroanatomy using MRI

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