Inactivation of the medial mammillary nucleus attenuates theta rhythm activity in the hippocampus in urethane-anesthetized rats

Żakowski, Witold; Braszka, Łukasz; Zawistowski, Piotr; Orzeł-Gryglewska, Jolanta; Jurkowlaniec, E

doi:10.1016/j.neulet.2017.02.057

Cited by 4 publications

(2 citation statements)

References 28 publications

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“…Following anterior thalamic lesions, rats show only modest changes in the CA1 theta band, alongside clearer evidence for a prefrontal cortex experience-dependent power change in the theta band, as well as a reduction in power change at lower theta frequencies in the dentate gyrus ( Ulrich et al, 2019 ). Meanwhile, inactivation of the medial mammillary nucleus (which projects to AM and AV) reduces the amplitude of hippocampal theta in anaesthetized rats ( Żakowski et al, 2017 ). Mammillothalamic tract damage also lowers hippocampal theta frequency, but can cause excessive inter-regional coherence, affecting both theta and gamma ( Dillingham et al, 2019 ).…”

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confidence: 99%

Time to retire the serial Papez circuit: Implications for space, memory, and attention

Aggleton¹,

Nelson²,

O’Mara³

2022

Neuroscience & Biobehavioral Reviews

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mentioning

confidence: 99%

Time to retire the serial Papez circuit: Implications for space, memory, and attention

Aggleton¹,

Nelson²,

O’Mara³

2022

Neuroscience & Biobehavioral Reviews

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“…MM thus appears to act as a HPC relay and its rhythmicity could totally depend on the HPC. However, recent data suggest that extra-HPC inputs to the MM may be more important for its functional outputs (Vann, 2013 ), with the HPC having a modulating role; and, under anesthesia, MM appears to contribute to HPC theta LFPs (Żakowski et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Bi-Directional Theta Modulation between the Septo-Hippocampal System and the Mammillary Area in Free-Moving Rats

Ruan

Young

McNaughton

2017

Front. Neural Circuits

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Hippocampal (HPC) theta oscillations have long been linked to various functions of the brain. Many cortical and subcortical areas that also exhibit theta oscillations have been linked to functional circuits with the hippocampus on the basis of coupled activities at theta frequencies. We examine, in freely moving rats, the characteristics of diencephalic theta local field potentials (LFPs) recorded in the supramammillary/mammillary (SuM/MM) areas that are bi-directionally connected to the HPC through the septal complex. Using partial directed coherence (PDC), we find support for previous suggestions that SuM modulates HPC theta at higher frequencies. We find weak separation of SuM and MM by dominant theta frequency recorded locally. Contrary to oscillatory cell activities under anesthesia where SuM is insensitive, but MM is sensitive to medial septal (MS) inactivation, theta LFPs persisted and became indistinguishable after MS-inactivation. However, MS-inactivation attenuated SuM/MM theta power, while increasing the frequency of SuM/MM theta. MS-inactivation also reduced root mean squared power in both HPC and SuM/MM equally, but reduced theta power differentially in the time domain. We provide converging evidence that SuM is preferentially involved in coding HPC theta at higher frequencies, and that the MS-HPC circuit normally imposes a frequency-limiting modulation over the SuM/MM area as suggested by cell-based recordings in anesthetized animals. In addition, we provide evidence that the postulated SuM-MS-HPC-MM circuit is under complex bi-directional control, rather than SuM and MM having roles as unidirectional relays in the network.

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The effect of pharmacological inactivation of the mammillary body and anterior thalamic nuclei on hippocampal theta rhythm in urethane-anesthetized rats

et al. 2017

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Inactivation of the medial mammillary nucleus attenuates theta rhythm activity in the hippocampus in urethane-anesthetized rats

Cited by 4 publications

References 28 publications

Time to retire the serial Papez circuit: Implications for space, memory, and attention

Time to retire the serial Papez circuit: Implications for space, memory, and attention

Bi-Directional Theta Modulation between the Septo-Hippocampal System and the Mammillary Area in Free-Moving Rats

The effect of pharmacological inactivation of the mammillary body and anterior thalamic nuclei on hippocampal theta rhythm in urethane-anesthetized rats

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