Inappropriate P-cadherin expression in the mouse mammary epithelium is compatible with normal mammary gland function

Radice, Glenn L.; Sauer, Christa; Kostetskii, Igor; Soler, Aléjandro Peralta; Knudsen, Karen A.

doi:10.1046/j.1432-0436.2003.7106005.x

Cited by 23 publications

(25 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As caderinas mais estudadas são as E-(epitelial), P-(placentária) e N-(neural) caderinas, conhecidas como caderinas clássicas (ROWLANDS et al, 2000).…”

Section: Caderinasunclassified

“…Sabe-se que a expressão das P-caderinas é restrita ao mioepitélio nas glândulas mamárias normais não lactantes de mulheres, porém tem sido observada em muitos carcinomas ductais (SOLER et al, 2002). Esta observação pode ser um indicativo de que as células tumorais têm características de células mioepiteliais ou de revestimento (RADICE et al, 2003). Sabe-se também que a perda de expressão das P-caderinas resulta em uma alteração fenotípica da glândula mamária, levando a um desenvolvimento precoce da glândula e diferenciação de células epiteliais (KNUDSEN e WHEELOCK, 2005).…”

Section: Caderinasunclassified

“…Duas pesquisas com tumores mamários caninos encontraram uma associação entre a expressão das E-caderinas e o tipo e diferenciação tumoral (RESTUCCI et al, 1997;REIS et al, 2003). Em outro trabalho realizado com 60 casos de tumores mamários caninos malignos, baseado na função das E-caderinas e das β-cateninas na invasão e proliferação tumoral, foi observado que a redução destas duas moléculas parece ocorrer paralelamente à ocorrência de invasividade, mas parece não estar correlacionada com a proliferação celular.…”

Section: Caderinas Como Indicadores De Prognósticounclassified

See 2 more Smart Citations

Expressão Das Caderinas Nos Tumores Mamários Em Cadelas

Piekarz¹,

Biondo²,

Amorim³

et al. 2008

AVS

View full text Add to dashboard Cite

RESUMO -As neoplasias mamárias são as que mais acometem as cadelas. O desenvolvimento do câncer pode levar à ocorrência de metástases que podem ser detectadas por marcadores protéicos. Um destes marcadores é a E-caderina, um membro da família das caderinas conhecida por desempenhar um papel importante na regulação da adesão intercelular em tecidos epiteliais. Estudos apontam que as E-caderinas podem funcionar como moléculas supressoras de tumor e de invasão. A atividade das caderinas é regulada por múltiplos mecanismos, incluindo a interação com outras proteínas como as cateninas. Nesta revisão os autores abordam a família das caderinas, incluindo sua função, fisiopatologia e potencial uso como marcadores de diagnóstico e prognóstico nas neoplasias mamárias na cadela. Palavras-Chave: caderina, imunoistoquímica, neoplasia mamária, cão.ABSTRACT -Mammary tumors are among the most common neoplasia of canine females. The occurrence of metastasis may be detected by proteic markers. Among them, exist the E-cadherin, a member of cadherin family known for its important role in the regulation of intercellular adhesion in epithelial tissues. Studies suggest that E-cadherin may function as a tumor and invasion suppressor molecule. Cadherin activity is regulated by multiple mechanisms, including interaction with other proteins such as catenins. In this review, the authors approach the cadherin family and other related adhesion proteins including its function, physiopathology and potential use as marker for diagnosis and prognosis of canine mammary tumors.

show abstract

“…As caderinas mais estudadas são as E-(epitelial), P-(placentária) e N-(neural) caderinas, conhecidas como caderinas clássicas (ROWLANDS et al, 2000).…”

Section: Caderinasunclassified

Section: Caderinas Como Indicadores De Prognósticounclassified

See 1 more Smart Citation

Expressão Das Caderinas Nos Tumores Mamários Em Cadelas

Piekarz¹,

Biondo²,

Amorim³

et al. 2008

AVS

View full text Add to dashboard Cite

show abstract

“…To further our understanding of cadherins in the normal mammary gland, as well as in mammary tumorigenesis (see sections below), our laboratories generated two transgenic mouse models with inappropriate expression of either P-cadherin [Radice et al, 2003] or Ncadherin [Knudsen et al, in press] in the adult mammary epithelium. In neither case were abnormalities seen in normal mammary gland architecture or function, including lactation and mammary gland regression following cessation of suckling.…”

Section: Cadherins and Catenins In The Normal Mammary Glandmentioning

confidence: 99%

“…For example, isolated myoepithelial cells can be highly invasive. As a strategy to determine if P-cadherin plays a causal role in aggressive tumor cell behavior, we generated a transgenic mouse model with forced expression of P-cadherin in the mammary epithelium, under control of the MMTV promoter [Radice et al, 2003]. These mice did not develop mammary tumors spontaneously, indicating that P-cadherin mis-expression by mammary epithelial cells does not induce tumors.…”

Section: P-cadherin In Breast Cancermentioning

confidence: 99%

Cadherins and the mammary gland

Knudsen

Wheelock

2005

J. Cell. Biochem.

Self Cite

View full text Add to dashboard Cite

Cadherin cell-cell adhesion proteins are critical for the formation of tissues from single cells. E-and P-cadherin play important roles in the architecture and function of the normal mammary gland. In breast cancers, the expression, or lack thereof, of E-cadherin can differentiate tumor types, whereas the misexpression of either P-cadherin or N-cadherin can be a marker of poor prognosis or increased malignancy, respectively. Additional research is needed to more precisely define the roles of both classical and desmosomal cadherins and their downstream signaling events, in the development and malignant behavior of breast cancers. J. Cell. Classical and desmosomal cadherins mediate cell-cell adhesion and are members of the larger cadherin protein family. They are single-pass transmembrane proteins whose extracellular domain promotes cell-cell adhesion, while the intracellular domain interacts with cytoplasmic proteins, including the a-, b-, g-catenins (also known as plakoglobin) and p120 in the case of classical cadherins. a-and b-catenin (alternatively plakoglobin) link classical cadherins directly and indirectly to the actin cytoskeleton, whereas plakoglobin, desmoplakins, and plakophilins link desmosomal cadherins to the intermediate filament cytoskeleton. By virtue of their homophilic interaction and cell-type specific expression, the classical cadherins initiate cell-cell adhesion and promote cell sorting, whereas the desmosomal cadherins provide added strength to cell-cell interactions. The p120 catenin is thought to regulate clustering of classical cadherins in the plane of the membrane and to regulate the strength of cadherin cell adhesion in both positive and negative ways. In addition to playing important roles in cell adhesion, p120 and b-catenin interact with nuclear

show abstract

Soluble P‐Cadherin Found in Human Semen

de Paul,

Bonaterra,

Soler

et al. 2005

Journal of Andrology

View full text Add to dashboard Cite

Cadherins constitute a family of calcium‐dependent cell‐cell adhesion molecules. P (placental)‐cadherin is a 118‐kd protein expressed by basal cells in epithelial tissues. P‐cadherin also has been described as a soluble protein in certain biological fluids, including human serum and breast milk. Here, we report the presence of an 80‐kD fragment of P‐cadherin in human semen. No significant differences were found in semen samples from fertile and nonfertile patients. Our results add evidence to previous data indicating that soluble fragments of P‐cadherin have a widespread distribution in bodily fluids and suggest that soluble P‐cadherin might have functions other than basal epithelial cell‐cell adhesion.

show abstract

Inappropriate P-cadherin expression in the mouse mammary epithelium is compatible with normal mammary gland function

Cited by 23 publications

References 34 publications

Expressão Das Caderinas Nos Tumores Mamários Em Cadelas

Expressão Das Caderinas Nos Tumores Mamários Em Cadelas

Cadherins and the mammary gland

Soluble P‐Cadherin Found in Human Semen

Contact Info

Product

Resources

About