Ecuador is a country in South America, where, in 2021, there were 849,874 companies that had total sales of USD 105.23 billion, which had 2,698,650 workers. This study was carried out with the aim of analyzing occupational accidents by industry type in Ecuador, focusing mainly on the construction and manufacturing industries. The data were provided upon express request to the National Directorate of General Occupational Risk Insurance of the Ecuadorian Social Security Institute. The data used in this study concerned accidents involving qualified workers affiliated with the Ecuadorian Social Security System. The data obtained were used to calculate the general accident rate, accident rate by sector, permanent disability rate, and mortality rate. Between 2016 and 2019, 6960 qualifying accidents occurred in Ecuador. Approximately 89.71 ± 0.36% of the accidents investigated involved men, and 50.28 ± 2.49% of these accidents caused permanent disability. The mortality rate was, on average, 10.60 ± 1.83%, 2018 being the year with the most deaths due to accidents at work. The Ecuadorian sector with the highest accident rate was the manufacturing industry with 26.15 ± 2.50%, followed by the construction industry with a rate of 17.47 ± 3.59%. The manufacturing industry had the highest rate, with a significant difference of accidents that resulted in permanent disability, with an average of 31.79 ± 2.85%, while the construction sector had the highest rate of fatal accidents, with an average of 25.82 ± 5.05%. This is the first study to report the number of qualified occupational accidents in Ecuador. With this study, a starting point is established for future analyses of the evolution of occupational accidents by type of industry in Ecuador. Future studies could determine the increase or decrease in the number of accidents, evaluate rates of permanent disability and death, and establish risk factors and preventive measures for each task or activity in all productive sectors.