Inception to actualization: Next generation coronary stent coatings incorporating nanotechnology

Tan, Aaron; Farhatnia, Yasmin; Mel, Achala de; Rajadas, Jayakumar; Alavijeh, Mohammad S.; Seifalian, Alexander M.

doi:10.1016/j.jbiotec.2013.01.020

Cited by 59 publications

(52 citation statements)

References 123 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Three more peaks were observed at different binding energies. A peak at 19 282.7 eV, is attributed to chromium carbide [33], while at 285.6 eV, it is attributed to oxygen-containing hydrocarbon 20 fragment C-OH [32]. The activation treatments increased the intensity of the hydroxyl group signal, 531.3 eV, and deceased the intensity 24 signal of oxides and H 2 O groups compared to CT surfaces, especially high is for PL activated surfaces (Fig.…”

Section: Surface Chemical Characterization 11mentioning

confidence: 99%

Biofunctionalization of REDV elastin-like recombinamers improves endothelialization on CoCr alloy surfaces for cardiovascular applications

Castellanos

Zenses

Grau

et al. 2015

Colloids and Surfaces B: Biointerfaces

View full text Add to dashboard Cite

To improve cardiovascular implant success, metal-based stents are designated to modulate endothelial cells adhesion and migration in order to prevent restenosis and late thrombosis diseases. Biomimetic coatings with extra-cellular matrix adhesive biomolecules onto stents surfaces are a strategy to recover a healthy endothelium. However, the appropriate bioactive sequences to selective promote growth of endothelium and the biomolecules surface immobilization strategy remains to be elucidated. In this study, biofunctionalization of cobalt chromium, CoCr, alloy surfaces with elastin-like recombinamers, ELR, genetically modified with an REDV sequence, was performed to enhance metal surfaces endothelialization. Moreover, physical adsorption and covalent bonding were used as biomolecules binding strategies onto CoCr alloy. Surfaces were activated with plasma and etched with sodium hydroxide previous to silanization with 3-chloropropyltriethoxysilane and functionalized with the ELR. CoCr alloy surfaces were successfully biofunctionalized and the use of an ELR with an REDV sequence, allows conferring bioactivity to the biomaterials surface, demonstrating a higher cell adhesion and spreading of HUVEC cells on the different CoCr surfaces. This effect is emphasized as increases the amount of immobilized biomolecules and directly related to the immobilization technique, covalent bonding, and the increase of surface charge electronegativity. Our strategy of REDV elastin-like recombinamers immobilization onto CoCr alloy surfaces via covalent bonding through organosilanes provides a bioactive surface that promotes endothelial cell adhesion and spreading.Response to Reviewers: Responses to reviewer's comments:We are grateful to reviewers for the critical comments and useful suggestions that have helped us to improve our paper. As indicated in the responses that follow, we have taken all these comments and suggestions into account in the revised version of our paper. Answers to the Reviewers' comments are written in blue. The main text is revised according to these answers and written in red. AbstractTo improve cardiovascular implant success, metal-based stents are designated to modulate endothelial cells adhesion and migration in order to prevent restenosis and late thrombosis diseases. Biomimetic coatings with extra-cellular matrix adhesive biomolecules onto stents surfaces are a strategy to recover a healthy endothelium. However, the appropriate bioactive sequences to selective promote growth of endothelium and the biomolecules surface immobilization strategy remains to be elucidated. In this study, biofunctionalization of cobalt chromium, CoCr, alloy surfaces with elastin-like recombinamers, ELR, genetically modified with an REDV sequence, was performed to enhance metal surfaces endothelialization. Moreover, physical adsorption and covalent bonding were used as biomolecules binding strategies onto CoCr alloy. Surfaces were activated with plasma and etched with sodium hydroxide previous to silanization with 3-chlor...

show abstract

Section: Surface Chemical Characterization 11mentioning

confidence: 99%

Biofunctionalization of REDV elastin-like recombinamers improves endothelialization on CoCr alloy surfaces for cardiovascular applications

Castellanos

Zenses

Grau

et al. 2015

Colloids and Surfaces B: Biointerfaces

View full text Add to dashboard Cite

show abstract

“…Many of the improvements of currently used devices and new solutions have been led by the variety and tailor-made properties of polymer coatings [1][2][3][4][5]. The application of hydrophilic-type coatings can provide advantages such as good wetting, inducement of capillary flow, good biocompatibility, low protein adsorption, and in contact with blood, reduction of the risk of thrombogenesis.…”

Section: Introductionmentioning

confidence: 99%

Friction behaviour of hydrophilic lubricious coatings for medical device applications

Niemczyk

Fray

Franklin

2015

Tribology International

View full text Add to dashboard Cite

The friction behaviour of new chitosan derivative coatings obtained by chemical modification of chitosan with fatty acids (linoleic and dilinoleic acid) has been investigated in order to explore their potential as endovascular catheter coatings and to benchmark them against commercially available coatings used in endovascular catheter applications. An in vitro tribological system was developed that was intended to represent to a limited extent the in vivo tribological conditions of a typical endovascular catheterization procedure. Continuous reciprocating sliding tests were carried out with uncoated and coated polymer specimens. The results showed that all of the coatings tested decreased the coefficient of friction compared to the uncoated polymer. Compared to a neat chitosan coating, the chitosan derivative coatings showed a clear reduction in the coefficient of friction to levels similar to those of the commercially-available coatings. A comparison between the friction results and contact angle measurements carried out on the coatings indicated that a range of contact angle values exists for which the friction coefficient is at a minimum. The reason for this is unclear and further studies are required in order to confirm and investigate the trend, especially within the context of hydrophilic lubricious coating development.

show abstract

“…These alloys have high x ray attenuation and strength levels when compared with stainless steel which is designed with thinner struts bless up the corrosion resistance, device radiopacity and resulting strength 23 . Currently in clinical trials cobalt alloys are launched.…”

Section: Cobalt -Chromium Alloy Stentmentioning

confidence: 99%

“…The AMS stent composed of bioabsorbable WE43 magnesium-alloy stent that have the property of marinating strength which is similar to that of 316L stainless steel 23 .With 63 patients in the PROGRESS-AMS trial, in the human the first metallic bioabsorbable stent was implanted which is balloon expandable and has a 165 μm thickness 27 . In trials it was found that there was rapid absorption of magnesium stents in humans and also the mechanical support was lasted for about days and/or weeks which caused it too short in order to prevent restenosis.…”

Section: Bioabsorbable Magnesium Stentmentioning

confidence: 99%

An Evolutionary Appraisal of the Efficacy of Coronary Artery Stents relevant to the Treatment of Coronary Heart Diseases

Amin

Ali

Minhas

2013

Int J of Biomed & Adv Res

View full text Add to dashboard Cite

Inception to actualization: Next generation coronary stent coatings incorporating nanotechnology

Cited by 59 publications

References 123 publications

Biofunctionalization of REDV elastin-like recombinamers improves endothelialization on CoCr alloy surfaces for cardiovascular applications

Biofunctionalization of REDV elastin-like recombinamers improves endothelialization on CoCr alloy surfaces for cardiovascular applications

Friction behaviour of hydrophilic lubricious coatings for medical device applications

An Evolutionary Appraisal of the Efficacy of Coronary Artery Stents relevant to the Treatment of Coronary Heart Diseases

Contact Info

Product

Resources

About