Incidence and factors associated with mortality of neonatal sepsis

Kardana, I Made

doi:10.14238/pi51.3.2011.144-8

Cited by 36 publications

(39 citation statements)

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“…3 The Neonatology Department of Sanglah Hospital, Denpasar reported in 2009 that of 159 neonatal deaths, 42.7% of deaths were due to respiratory distress, 17.6% due to sepsis, and 9.4% due to low birth weight and other causes. 4 The initial handling of neonatal emergencies (resuscitation) and the availability of the NICU are critical to the prognosis and the likelihood of death in neonates. 5 Some health centers have developed a scoring system to determine severity of illness in neonates.…”

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Predictive value of Score for Neonatal Acute Physiology and Perinatal Extension II for neonatal mortality in Sanglah Hospital, Denpasar, Indonesia

Aryana¹,

Kardana²,

Adipura³

2017

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Background Neonatal mortality, which is largely caused by severe illness, is the biggest contributor to overall infant mortality. The World Health Organization (WHO) estimated that 4 million neonates die yearly worldwide, often due to severe infection and organ system immaturity. Neonates with severe illness require treatment in the neonatal intensive care unit (NICU), in which a reliable assessment tool for illness severity is needed to guide intensive care requirements and prognosis. Neonatal disease severity scoring systems have been developed, including Score for Neonatal Acute Physiology and Perinatal Extension II (SNAppE II), but it has never been validated in our setting. Objective To study the prognostic value of SNAppE II as a predictor of neonatal mortality in Sanglah Hospital, Denpasar, Indonesia. Methods This prospective cohort study was conducted in the NICU of Sanglah Hospital, Denpasar from November 2014 to February 2015. All neonates, except those with congenital anomaly, were observed during the first 12 hours of admission and their outcomes upon discharge from the NICU was recorded. We assessed the SNAppE II cut-off point to predict neonatal mortality. The calibration of SNAppE II was done using the HosmerLemeshow goodness-of-fit test, and discrimination of SNAppE II was determined from the receiver-operator characteristic (ROC) curve and area under the curve (AUC) value calculation. Results During the period of study, 63 children were eligible, but 5 were excluded because of major congenital abnormalities. The SNAppE II optimum cut-off point of 37 gave a high probability of mortality and the ROC showed an AUC of 0.92 (95%CI 0.85 to 0.99). The Hosmer-Lemeshow goodness-of-fit test showed a good calibration with p=1.0 Conclusion The SNAppE II has a good predictive ability for neonatal mortality in Sanglah Hospital, Denpasar, Indonesia.[Paediatr Indones. 2016;56:257-61.

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Predictive value of Score for Neonatal Acute Physiology and Perinatal Extension II for neonatal mortality in Sanglah Hospital, Denpasar, Indonesia

Aryana¹,

Kardana²,

Adipura³

2017

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“…9 Penelitian di Denpasar juga melaporkan insiden sepsis neonatorum lebih tinggi pada bayi laki-laki dibandingkan perempuan. 10,11 Lawn dkk 12 melaporkan bahwa terdapat pengaruh jenis kelamin terhadap insiden sepsis neonatorum, lebih banyak dijumpai pada bayi laki-laki daripada bayi perempuan. Hal tersebut disebabkan oleh peran faktor sex-linked pada kerentanan pejamu terhadap infeksi.…”

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“…Pada periode JanuariDesember 2008 di RSUP Sanglah, angka mortalitas sepsis neonatorum 28,3%. 10 Masih di rumah sakit yang sama, mortalitas sepsis neonatorum periode JanuariDesember 2010 30,4%.…”

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Hubungan Kadar Neuron-Specific Enolase Serum dengan Mortalitas pada Sepsis Neonatorum

Hartanto

Masloman

Rompis

et al. 2016

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Latar belakang. Sepsis neonatorum menyebabkan respons inflamasi berlebih sehingga terjadi kerusakan sawar darah otak, disfungsi serebrovaskular dan oksigenasi, gangguan neurotransmiter, degenerasi sel neuron, edema serebral yang berakhir pada kematian sel. Penelitian sebelumnya mendapatkan peningkatan kadar NSE serum pada pasien anak dengan sepsis berat dan syok septik. Tujuan. Mengetahui hubungan kadar NSE serum dengan mortalitas pada sepsis neonatorum. Metode. Digunakan metode analitik observasional kohort prospektif dari bulan Agustus 2015 sampai November 2015. Sampel diambil secara konsekutif dan didapatkan 42 bayi dengan sepsis neonatorum. Analisis statistik diuji dengan regresi logistik dan korelasi Pearson. Orang tua atau wali diminta menandatangani informed consent. Penelitian ini dilaksanakan dibawah persetujuan komite etik. Hasil. Terdapat hubungan antara kadar NSE serum dengan mortalitas (koefisien korelasi r pb =0,738 dengan nilai p<0,001). Cutt-off point kadar NSE serum yaitu 21,9 µg/L dengan sensitivitas 91,3% dan spesifisitas 94,7% dalam menentukan mortalitas pada sepsis neonatorum. Kesimpulan. Semakin tinggi kadar NSE serum maka semakin besar peluang bayi dengan sepsis akan meninggal. Sari Pediatri 2016; 17(6):450-4. Kata kunci: neuron-specific enolase, mortalitas, sepsis neonatorumBackground. Neonatal sepsis causes excessive inflammatory responses, which in turn causes damage to the blood brain barrier, cerebrovascular dysfunction and oxygenation, neurotransmitter disorders, neuron degeneration, and cerebral edema, that ended in the cell death. Previous studies showed elevated levels of serum NSE in pediatric patients with severe sepsis and septic shock. Objective. To determine the relationship of serum NSE levels with mortality in neonatal sepsis. Method. We conducted an observational analytical study with prospective cohort approach from August 2015 until November 2015. Samples were taken consecutively. Forty-two infants with neonatal sepsis were enrolled into the study. The relationship between serum NSE levels with mortality was tested with logistic regression analysis and Pearson correlation test. Informed consent was obtained from parents or guardians. This study was approved by ethical comittee. Results. There is a significant correlation between serum NSE levels with mortality in neonatal sepsis (correlation coefficient r pb = 0.738 with p <0.001). Cut-off point of serum NSE levels to determine risk of mortality is 21.9 µg/L with a sensitivity of 91.3% and specificity of 94.7%. Conclusion. This study shows that the higher levels of serum NSE, the greater chances of newborns with sepsis will die. Sari Pediatri 2016; 17(6):450-4.

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“…In general, neonatal sepsis, sepsis neonatorum or neonatal septicemia are synonyms that being used to describe a systemic response of a neonate to infection [1]. Multiple maternal, neonatal and environmental factors play a role in the development of neonatal sepsis (2].…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of neutrophil CD64 in low birth weight neonates with sepsis

Sayed

Kamal

Hakim

et al. 2019

Annals of Neonatology Journal

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Introduction: Neonatal sepsis represents a major health problem with high mortality and morbidity rates. Although early diagnosis of neonatal sepsis is very important for proper management yet it remains a difficult task. Neutrophil CD64 (nCD64) is used as a marker for the diagnosis of sepsis, requiring a small sample volume, short turnaround time. Objectives: In this study we aimed to study the diagnostic performance of nCD64 against routine markers in low birth weight neonates (LBWN) with sepsis. Patients and methods: A case control study was conducted on 40 LBWN suspected clinically to have early onset neonatal sepsis against 20 neonates clinically free of sepsis as control. Investigations included CBC, CRP, blood culture andnCD64 expression. Results: among the studied markers of sepsis; immature neutrophil count, immature /mature ratio, immature/total ratio, CRP and nCD64 were significantly higher in suspected group than control (p value 0.007, 0.001, 0.002, 0.001, and 0.001 respectively). Among the group of neonates with suspected sepsis, blood culture of 11 cases (27.5%) did not show growth. nCD64 showed the highest sensitivity and specificity; 100% each. Immature neutrophil count and total leucocytic count showed the lowest sensitivity 40% and mature neutrophil showed the lowest specificity 45%. The expression of nCD64 in those neonates who died as a complication of sepsis was significantly higher than those who survived (p value 0.001). Conclusion: nCD64 is a reliable marker for the diagnosis of early onset neonatal sepsis in LBWN with a significant predictive value for disease course.

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Incidence and factors associated with mortality of neonatal sepsis

Cited by 36 publications

References 0 publications

Predictive value of Score for Neonatal Acute Physiology and Perinatal Extension II for neonatal mortality in Sanglah Hospital, Denpasar, Indonesia

Predictive value of Score for Neonatal Acute Physiology and Perinatal Extension II for neonatal mortality in Sanglah Hospital, Denpasar, Indonesia

Hubungan Kadar Neuron-Specific Enolase Serum dengan Mortalitas pada Sepsis Neonatorum

Prognostic value of neutrophil CD64 in low birth weight neonates with sepsis

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