Incidence and Remission of Asthma in Schoolchildren: Report From the Obstructive Lung Disease in Northern Sweden Studies

Rönmark, Eva; Jonsson, E. Niclas; Platts-Mills, Thomas A.E.; Lundbäck, Bo

doi:10.1542/peds.107.3.e37

Cited by 62 publications

(52 citation statements)

References 35 publications

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“…However, in the present analysis quitting smoking was found to favour remission of asthma. This finding is supported by RÖ NMARK et al [7], who concluded that remission of asthma is associated with cessation of smoking.…”

Section: Asthma Remission In Northern Europe M Holm Et Alsupporting

confidence: 56%

“…One of the few studies on asthma remission rate in adults investigated a cohort of 300 middle-aged and elderly subjects [7]. This study reported remission (no use of asthma medicines, no recurrent wheezing and no attacks of shortness of breath) in 6% of subjects at a follow-up 10 yrs after a validated diagnosis of current asthma, equivalent to a remission rate of six per 1,000 person-yrs.…”

Section: Discussionmentioning

confidence: 99%

“…Those with mild asthma had an increased ''risk'' of remission. In another study of Swedish children, RÖ NMARK et al [7] found that a negative skin-prick test at baseline predicted remission of asthma. In the Swedish part of the European Community Respiratory Health Survey (ECRHS), young age appeared to predict remission [8].…”

mentioning

confidence: 97%

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Remission of asthma: a prospective longitudinal study from northern Europe (RHINE study)

Holm

Omenaas²,

Gíslason³

et al. 2007

Eur Respir J

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The aim of the present study was to investigate the remission rate of adult asthma in a general population sample in relation to age, sex, asthma symptoms, allergic rhinitis and smoking.A follow-up of the random population samples from the European Community Respiratory Health Survey in Northern Europe was conducted from 1999-2001 on 1,153 individuals (aged 26-53 yrs) with reported asthma. Remission was defined as no asthmatic symptoms in two consecutive years and no current use of asthma medication. Remission rates per 1,000 personyrs were calculated and Cox regression models, adjusting for confounders, were used to estimate hazard ratios (HR) with 95% confidence intervals (CI).An average remission rate of 20.2 per 1,000 person-yrs was found. There was no significant difference according to sex; the remission rates were 21.7 and 17.8 per 1,000 person-yrs in females and males, respectively. An increased remission rate was observed among subjects who quit smoking during the observation period. Subjects not reporting any asthma symptom at baseline had an increased remission rate. In the Cox regression model, ex-smoking (HR 1.65, 95% CI 1.01-2.71) was associated with increased remission rate, and reporting any asthma symptom at baseline was associated with decreased remission rate (HR 0.7, 95% CI 0.40-0.90).In conclusion, the present prospective longitudinal study showed that quitting smoking and the presence of mild disease appeared to favour remission.

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Section: Asthma Remission In Northern Europe M Holm Et Alsupporting

confidence: 56%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Remission of asthma: a prospective longitudinal study from northern Europe (RHINE study)

Holm

Omenaas²,

Gíslason³

et al. 2007

Eur Respir J

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“…large-scale studies on the epidemiology of COPD, asthma and type-1 allergy in Northern Sweden which started in 1985. (13,14) Today, longitudinal studies of a number of cohorts are under way, including a total of approximately 40,000 children, adults, and elderly persons. The first survey of the second cohort of the OLIN studies included pulmonary function tests performed from 1993 to 1995 on 1,900 subjects born in 1925-26, 1940-41, 1955-56 and 1970-71.…”

Section: Study Samplementioning

confidence: 99%

Factors affecting chronic obstructive pulmonary disease (COPD)-related costs: a multivariate analysis of a Swedish COPD cohort

et al. 2008

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Methods: A cohort of 179 subjects with COPD was interviewed over the telephone on four occasions about their annual use of COPD-related resources. The data set and the explanatory variables were analysed by means of multivariate regression techniques for six different types of cost: societal (or total), direct (health care) and indirect (productivity), and three subcomponents of direct costs -hospitalisation, outpatient, and medication.Results: Poor lung function, dyspnoea and asthma were independently associated with higher costs. Poor lung function (severity of COPD) significantly increased all six examined cost types. Dyspnoea (breathing problems) also did this, though to a varying extent. The presence of reported asthma increased total, direct, outpatient and medication costs. Conclusions:Poor lung function and, to a lesser extent, extent of dyspnoea and concomitant asthma, were all strongly associated with higher COPD-related costs. Strong efforts should be made to prevent the progression of COPD and its symptoms.Word count: 178

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“…5,16 The Obstructive Lung Disease in Northern Sweden studies have reported on the prevalence and incidence of asthma, allergic diseases and sensitization in children, as well as associated factors such as damp housing, environmental tobacco smoke, and traffic-related air pollution since 1996. 12,[17][18][19][20][21] In the current study, a well-defined cohort of asthmatic children derived from the first pediatric Obstructive Lung Disease in Northern Sweden Studies cohort was followed annually from age 7-to 8-years to age 19 years. The aim was to study the remission and persistence of asthma, as well as to determine any correlated factors.…”

mentioning

confidence: 99%

Remission and Persistence of Asthma Followed From 7 to 19 Years of Age

Andersson

Hedman²,

Bjerg

et al. 2013

Pediatrics

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BACKGROUND AND OBJECTIVE: To date, a limited number of population-based studies have prospectively evaluated the remission of childhood asthma. This work was intended to study the remission and persistence of childhood asthma and related factors. METHODS: In 1996, a questionnaire was distributed to the parents of all children aged 7 to 8 years in 3 municipalities in northern Sweden, and 3430 (97%) participated. After a validation study, 248 children were identified as having asthma; these children were reassessed annually until age 19 years when 205 (83%) remained. During the follow-up period lung function, bronchial challenge testing, and skin prick tests were performed. Remission was defined as no use of asthma medication and no wheeze during the past 12 months as reported at endpoint and in the 2 annual surveys preceding endpoint (ie, for ≥3 years). RESULTS: At age 19 years, 21% were in remission, 38% had periodic asthma, and 41% persistent asthma. Remission was more common among boys. Sensitization to furred animals and a more severe asthma (asthma score ≥2) at age 7 to 8 years were both inversely associated with remission, odds ratio 0.14 (95% confidence interval 0.04–0.55) and 0.19 (0.07–0.54), respectively. Among children with these 2 characteristics, 82% had persistent asthma during adolescence. Asthma heredity, damp housing, rural living, and smoking were not associated with remission. CONCLUSIONS: The probability of remission of childhood asthma from age 7- to 8-years to age 19 years was largely determined by sensitization status, particularly sensitization to animals, asthma severity, and female gender, factors all inversely related to remission.

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Incidence and Remission of Asthma in Schoolchildren: Report From the Obstructive Lung Disease in Northern Sweden Studies

Cited by 62 publications

References 35 publications

Remission of asthma: a prospective longitudinal study from northern Europe (RHINE study)

Remission of asthma: a prospective longitudinal study from northern Europe (RHINE study)

Factors affecting chronic obstructive pulmonary disease (COPD)-related costs: a multivariate analysis of a Swedish COPD cohort

Remission and Persistence of Asthma Followed From 7 to 19 Years of Age

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