Incidence and risk predictors analysis of adverse donor reactions in whole blood donation

Prakash, Satya; Das, Pankaj; Mishra, Debasish; Routray, Suman Sudha; Naik, Archana; Mukherjee, Somnath

doi:10.1016/j.tracli.2020.09.003

Cited by 7 publications

(9 citation statements)

References 21 publications

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“…studies have shown that female donors have a higher probability of ADRs. [9][10][11] But in our study, the rate of ADRs among females is higher than among males except for 2020, which may be affected by COVID-19. Based on this, we can not confirm that the ADRs in Shenzhen are related to gender.…”

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confidence: 59%

Sociodemographic Factors Related to Adverse Donor Reactions in Shenzhen

Sun,

Yu,

et al. 2023

IJGM

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Background:The adverse donor reaction (ADR) means the uncomfortable feeling felt by blood donors during the whole process of blood donation, which can affect the blood donation behavior of blood donors. So, it is very necessary for blood centers to monitor and prevent it. Methods: Data about ADRs in Shenzhen Blood Center from January 2018 to December 2022 were collected, and correlation analysis was conducted using SPSS 24.0 software. Results: From January 2018 to December 2022, a total of 1265 ADRs occurred in 642,767 blood donations in Shenzhen Blood Center, with an incidence of 0.20%. Most of the ADRs were mild and occurred during blood collections (>90%). The ADR rate of young individuals aged 18-29 years old was the highest (p<0.0001). In addition, a higher ADR rate was observed in first-time blood donors, whole blood donors, and blood donors who donated in the mobile sites (p<0.05). Conclusion:The occurrence of ADRs is related to the sociodemographic factors of blood donors, including age, donation type, donation history, and donation sites. Shenzhen Blood Centers should pay special attention to the process of blood donation among young blood donors aged 18-29 years old, first-time blood donors, whole-blood donors, and blood donors who donate at mobile sites to further reduce the occurrence of ADRs.

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confidence: 59%

Sociodemographic Factors Related to Adverse Donor Reactions in Shenzhen

Sun,

Yu,

et al. 2023

IJGM

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“…Female gender was the second most frequent factor in predicting VVRs in this study: the adverse reaction rate of females was significantly higher than that of males, a factor that has been noted by other researchers. 1,20 Autonomic nerve function differs in males vs females, and the physiological response of the female body to rapid reduction of blood volume is more sensitive than that of the male body. 21 Other possible reasons include the generally smaller circulating blood volume in females vs males: providing the same plasma donation volume, females are more likely to have VVRs.…”

Section: Discussionmentioning

confidence: 99%

Development and validation of a nomogram for predicting the risk of vasovagal reactions after plasma donation

Zhao

Dong²,

Dong³

et al. 2023

J of Clinical Apheresis

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Background and ObjectivesVasovagal reactions (VVRs) are the most common adverse reactions and are frequently associated with serious donor adverse events. Even mild VVRs can lead to a significant reduction in the likelihood of subsequent donations. The purpose of this study is to explore the factors related to the occurrence of VVRs after plasma donation and to construct a nomogram to identify individuals at risk for VVRs to improve the safety of plasma donors.Materials and MethodsWe collected the donation data from July 2019 to June 2020 from a plasma center in Sichuan, China, to explore the independent risk factors for vasovagal reactions. From these data, we constructed and validated a predictive model for vasovagal reactions.ResultsVVRs after plasma donation occurred 737 times in 120 448 plasma donations (0.66%). Gender, season, donor status, weight, pulse, duration of donation, and cycle were independent risk factors for VVRs (P< 0.05). The concordance index (C‐index) of a logistic model in the derivation cohort was 0.916, with a Hosmer‐Lemeshow goodness‐of‐fit probability of 0.795. The C‐index of a logistic model in the validation cohort was 0.916, with a Hosmer‐Lemeshow goodness‐of‐fit probability of 0.224. The calibration curve showed that the predicted results were in good agreement with the actual observed results.ConclusionThis study preliminarily constructed and verified a prediction model for VVRs after plasma donation. The model nomogram is practical and can identify high‐risk donors.

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“…Notably, donor studies report highly varied incidences of AE, ranging from 0.1% to 36% of donations, although most are of little clinical significance 14,15,17–19 . Not surprisingly, a consensus was only recently reached for reporting donation AE 20 and for grading their severity 21 …”

Section: Introductionmentioning

confidence: 99%

Adverse effects of therapeutic phlebotomies: Prospective study of 587 procedures

Romón,

Domíguez‐García,

Fernández

et al. 2024

Transfusion

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BackgroundTherapeutic phlebotomy (TP), a widely used medical procedure, can be performed on diverse patients with iron overload or polyglobulia. However, its adverse events are not well known as most of the information on phlebotomy is derived from healthy blood donors (0.1%–5.3%). In contrast, TP is applicable to a broader, more complex population with comorbidities and old age. To ascertain the incidence of adverse events in phlebotomies, we conducted a prospective study on patients who attended our Unit.Study Design and MethodsWe prospectively gathered data from patients referred to our Unit for TP. Data regarding demographics, health status, and adverse events within at least 24 h of phlebotomy were gathered via a structured questionnaire during each visit.ResultsBetween August 2021 and September 2022, 189 patients underwent 587 procedures. Most patients were men, over 60 (57.3%) had comorbidities, and 93% underwent at least two procedures during the study period. Twenty patients (10.8%) presented 25 adverse events (4.3% of phlebotomies), usually vasovagal reactions, none of which were clinically relevant, and all were managed by nursing staff on site, with full patient recovery.DiscussionThe rate of adverse events (<5%) in patients undergoing TP was low and comparable to that seen in healthy blood donors. Consequently, even old patients and those with some comorbidities can safely undergo TP when the process is carefully managed.

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Incidence and risk predictors analysis of adverse donor reactions in whole blood donation

Cited by 7 publications

References 21 publications

Sociodemographic Factors Related to Adverse Donor Reactions in Shenzhen

Sociodemographic Factors Related to Adverse Donor Reactions in Shenzhen

Development and validation of a nomogram for predicting the risk of vasovagal reactions after plasma donation

Adverse effects of therapeutic phlebotomies: Prospective study of 587 procedures

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