Incidence of Carcinoma Prostate in Transurethral Resection Specimen in a Teaching Hospital of Nepal

Abstract

Introduction: As suggested through several autopsy studies there is a high prevalence of latent prostate cancer in the population. A much smaller proportion of prostate cancer is detected because of clinical symptoms. This study was done to identify the rates of incidentally detected prostate cancer in patients undergoing surgical management of Benign Prostatic Hyperplasia (BPH) in our centre.
 
 Methods: A retrospective review was done on all transurethral resections of the prostate (TURP) cases from May 2014 to May 2015 at a single tertiary care institution. One hundred and three men, aged 40 to 88 year, underwent TURP and their specimens were sent for the histopathological analysis.
 
 Results: Five (4.85%) patients were diagnosed with the prostate cancer. All the five patients had Gleason score of seven or more. Two patients had moderately differentiated adenocarcinoma with Gleason score of seven. Three patients had poorly differentiated adenocarcinoma with Gleason score of eight or above. The Prostate cancer was seen only in the age group above 65 years but it was not statistically significant.
 
 Conclusion: Our series demonstrated that 4.85% of patients had latent prostate cancer. It occurs mainly in men above 65 years of age though this was not statistically significant.

Histomorphological spectrum of prostatic lesions: a retrospective analysis of transurethral resection of prostate specimens

“…Thapa N et al and Begum Z et al also evaluated only TURP specimens in their respective studies. 12,13 Thapa N et al in their study found 92.2% cases were of BPH, 4.8% were prostatic cancers and these observations were comparable with our findings. 12 Begum Z et al also observed almost similar percentage of BPH and adenocarcinoma cases constituting 96% and 4% respectively.…”

“…12,13 Thapa N et al in their study found 92.2% cases were of BPH, 4.8% were prostatic cancers and these observations were comparable with our findings. 12 Begum Z et al also observed almost similar percentage of BPH and adenocarcinoma cases constituting 96% and 4% respectively. 13 The age of the patients in our study ranged from 39 years to 92 years.…”

“…This corroborates with findings of Shirish C et al, Thapa N et al and Josephine A. 1,12,14 BPH cases were maximum in the seventh decade in our study which was similar to observations made by Kasliwal N et al, Arya RC et al, Kumar M et al [15][16][17] PIN was noted in our study, between 61-80 years with maximum number of HGPIN cases in 71-80 years age group and LGPIN cases in 61-70 years age group. This correlates with the study of Khatib W et al 18 We observed that the commonly affected age group by malignancy was 71-80 years which was similar to findings of Kasliwal N et al and Deshmukh BD et al 15,19 BPH represents nodular enlargement of the prostate caused by hyperplasia of glandular and stromal components.…”

“…Five of these cases had poorly differentiated adenocarcinoma with Gleason's score of more than 7 while 3 cases had moderately differentiated adenocarcinoma with Gleason's score of 7. Comparable results were reported by Thapa N et al and Begum Z et al 12,13 …”

“…However, in PSA era, the rate of detection of incidental prostate cancer on TURP has been reported to be 4.1-16.7%. 9,12,27 Most prostatic cancers arise from peripheral zone and tumors detected exclusively in transitional zone account only for 2-7%. In the present study, prostatic carcinoma was diagnosed in 8 patients (3.26%).…”