Incidence of influenza during pregnancy and association with pregnancy and perinatal outcomes in three middle-income countries: a multisite prospective longitudinal cohort study

Dawood, Fatimah S.; Kittikraisak, Wanitchaya; Patel, Archana; Hunt, Danielle; Suntarattiwong, Piyarat; Wesley, Meredith G; Thompson, Mark G.; Soto, Giselle; Mundhada, Shailendra; Arriola, Carmen Sofia; Azziz‐Baumgartner, Eduardo; Brummer, Tana; Cabrera, Santiago; Chang, Howard H.; Deshmukh, Madhavi; Ellison, Damon W.; Florian, Richard; Gonzales, Oswaldo; Kurhe, Kunal; Kaoiean, Surasak; Rawangban, Boonsong; Lindstrom, Stephen; Llajaruna, Edwin; Mott, Joshua A.; Saha, Siddhartha Sankar; Prakash, Amber; Mohanty, Sumit; Sinthuwattanawibool, Chalinthorn; Tinoco, Yeny

doi:10.1016/s1473-3099(20)30592-2

Cited by 71 publications

(78 citation statements)

References 23 publications

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“…These associations remained significant when adjusted for confounders by multiple logistic regression. Our findings agree with 2 recently published studies (7,8) showing an association of SARI, including influenza, among pregnant women with low birthweights. Pregnant mothers who had SARI were more likely to require medical assistance during labor than those who did not have SARI.…”

Section: Discussionsupporting

confidence: 93%

Perinatal Outcomes of Asynchronous Influenza Vaccination, Ceará, Brazil, 2013–2018

Filho¹,

Francisco²,

Lima³

et al. 2021

Emerg. Infect. Dis.

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R espiratory infections are a leading cause of disease and death worldwide (1,2), especially among young children and older adults. However, the adverse effects of respiratory infections on pregnant women and fetal development are understudied, particularly in low-and middle-income countries. Respiratory infections in pregnant women can negatively affect birth outcomes, early childhood growth, and neurodevelopment (3).Infl uenza epidemics are associated with excess rates of pneumonia, related hospitalizations, and death (4). Pregnant women and their infants are at heightened risk for severe infl uenza (5,6). In 2020, Regan et al. ( 7) conducted a retrospective cohort study of pregnant women from Australia, Canada, Israel, and the United States; results showed hospitalizations for acute respiratory or febrile illnesses were associated with low birthweight but not small-for-gestational-age births. A prospective cohort study of pregnant women in India, Peru, and Thailand showed infl uenza during pregnancy is associated with late pregnancy loss and reduced mean birthweight (8). A meta-analysis ( 9) found that during the 2009 pandemic of infl uenza A(H1N1)pdm09, the risk for infl uenza hospitalization was 2-fold higher for women who were pregnant than those who were not. Children born to mothers infected during pregnancy face potential adverse consequences for physical and neurocognitive development. These consequences resemble the growth and developmental challenges described in children born to undernourished mothers in global settings with high rates of pneumonia and diarrhea (10-14).In 2018, Almeida et al. (15) revealed that 12 of 27 states in Brazil demonstrate annual seasonal infl uenza activity. States along the coast generally have seasonal infl uenza patterns, whereas states in the North and Central West regions exhibit no readily identifi able seasonality, probably because landlocked states might have more complex and diffi cult to detect transmission patterns. In the semiarid state of Ceará, which has a population of ≈8.8 million persons, peak seasonal infl uenza

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Section: Discussionsupporting

confidence: 93%

Perinatal Outcomes of Asynchronous Influenza Vaccination, Ceará, Brazil, 2013–2018

Filho¹,

Francisco²,

Lima³

et al. 2021

Emerg. Infect. Dis.

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“…Key issues around pregnancy and delivery were addressed in Global burden of disease studies [16][17][18]. A number of related studies from this region were reviewed [19][20][21][22].…”

Section: Discussionmentioning

confidence: 99%

Comparing the Effectiveness of Transrectal Misoprostol with Intravenous Oxytocin in Active Management of Third Stage of Labour in Preventing Post-partum Hemorrhage

Patel

Borkar

2021

JPRI

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Background: PPH which is 500 ml or more blood loss in 24 hours of birth . Uterine atony has been the commonest cause of PPH. To prevent PPH uterotonics like oxytocin and misoprostol should be given. Intravenous route of oxytocin has rapid effect, but is associated with cardiovascular side effects like rise in heart rate and decrease in blood pressure. Slower rate of absorption, lower peak levels and reduced adverse effects is seen with misoprostol given rectally when compared to sublingual and oral routes. This study aims to compare the effectiveness of transrectal misoprostol and intravenous oxytocin in preventing post-partum haemorrhage. Objectives: To compare the effectiveness of 600mcg transrectal misoprostol with 10IU intravenous oxytocin in active management of third stage of labour in preventing PPH and recommend technique for active management of third stage of labour in preventing PPH. Methodology: Women randomized into two groups for prevention of PPH and are given 600ug of misoprostol per rectally and 10IU oxytocin intravenously. Duration of third stage, the blood volume in kidney tray and additional blood loss in sterile surgical pads for 24hrs will be noted. The blood loss due to episiotomy will be taken as 50ml.Need of additional uterotonics(oxytocin or misoprostol), blood transfusion, removal of placenta manually, haemoglobin before and after delivery will be noted. Monitoring of patients for vital signs, uterine tone, fundal height and vaginal bleeding for 2 hour will be done. Result: The expected outcome of the study will be a significant difference in the blood loss during third stage of labour and 24 hours in post-partum period when uterotonics like oxytocin or misoprostol are used in managing third stage of labour actively. Conclusion: Our study will show the effect of intravenous oxytocin and transrectal misoprostol in managing third stage of labour actively to prevent post-partum hemorrhage.

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“…Influenza immunization programs expanded to include pregnant women following the 2012 WHO SAGE recommendations, 38 given increased risk of severe maternal disease and mortality as well as increased risk of pregnancy loss, preterm birth, and low birthweight birth. 39,40 Evidence indicates that maternal influenza immunization prevents influenza illnesses in pregnant women and their infants, [41][42][43] although data about severe illness prevention in LMICs are limited. 44,45 The PAHO and partners have conducted operational research studies in LAC to define optimal strategies to improve vaccination of pregnant women (and health workers).…”

Section: Strengthening Influenza Surveillance Monitoring and Data Utilizationmentioning

confidence: 99%

Seasonal Influenza Prevention and Control Progress in Latin America and the Caribbean in the Context of the Global Influenza Strategy and the COVID-19 Pandemic

Vicari

Olson

Vilajeliu

et al. 2021

The American Journal of Tropical Medicine and Hygiene

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Each year in Latin America and the Caribbean, seasonal influenza is associated with an estimated 36,500 respiratory deaths and 400,000 hospitalizations. Since the 2009 influenza A(H1N1) pandemic, the Region has made significant advances in the prevention and control of seasonal influenza, including improved surveillance systems, burden estimates, and vaccination of at-risk groups. The Global Influenza Strategy 2019–2030 provides a framework to strengthen these advances. Against the backdrop of this new framework, the University of Colorado convened in October 2020 its Immunization Advisory Group of Experts to review and discuss current surveillance, prevention, and control strategies for seasonal influenza in Latin America and the Caribbean, also in the context of the COVID-19 pandemic. This review identified five areas for action and made recommendations specific to each area. The Region should continue its efforts to strengthen surveillance and impact evaluations. Existing data on disease burden, seasonality patterns, and vaccination effectiveness should be used to inform decision-making at the country level as well as advocacy efforts for programmatic resources. Regional and country strategic plans should be prepared and include specific targets for 2030. Existing investments in influenza prevention and control, including for immunization programs, should be optimized. Finally, regional partnerships, such as the regional networks for syndromic surveillance and vaccine effectiveness evaluation (SARInet and REVELAC-i), should continue to play a critical role in continuous learning and standardization by sharing experiences and best practices among countries.

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Incidence of influenza during pregnancy and association with pregnancy and perinatal outcomes in three middle-income countries: a multisite prospective longitudinal cohort study

Cited by 71 publications

References 23 publications

Perinatal Outcomes of Asynchronous Influenza Vaccination, Ceará, Brazil, 2013–2018

Perinatal Outcomes of Asynchronous Influenza Vaccination, Ceará, Brazil, 2013–2018

Comparing the Effectiveness of Transrectal Misoprostol with Intravenous Oxytocin in Active Management of Third Stage of Labour in Preventing Post-partum Hemorrhage

Seasonal Influenza Prevention and Control Progress in Latin America and the Caribbean in the Context of the Global Influenza Strategy and the COVID-19 Pandemic

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