Musculoskeletal disorders are injuries over a period of time due to workers' exposure to some multifactorial work hazards. The major causes of musculoskeletal injuries are long work involving forceful, repeating movements, and maintaining awkward body postures. This paper focuses on the associated prevalence, complications, predisposing factors, related output performance, and management of musculoskeletal disorders among health-related professionals. Work-related musculoskeletal disorders (WMSD) are unhealthy situations that occur in work environments to workers thereby leading to health hazards. Which in most cases leads to high costs to employers, for instance, absenteeism lost productivity and increased health care, disability, worker’s compensation costs, and so on. MSD cases are more severe than the average nonfatal injury or illness. Nurses have the highest incident rate of WMSD but are not fatal and are followed by physicians, pharmacists, laboratory scientists, and physiotherapists in that order. The body parts of these health workers associated with WMSD include both the upper and lower limbs, with the structure of the upper limb being the most affected. Therefore, relevant measures should be taken by policymakers to adjust workplace ergonomics and staff welfare should be paramount to reduce musculoskeletal injuries among professional health workers, and they should be enlightened on proper workplace ergonomics.