Incidence, Persistence, Clearance, and Correlates of Genital Human Papillomavirus Infection and Anogenital Warts in a Cohort of Men Living With Human Immunodeficiency Virus in South Africa

Chikandiwa, Admire; Pisa, Pedro T.; Müller, Etienne; Tamalet, Catherine; Mayaud, Philippe; Chersich, Matthew; Delany‐Moretlwe, Sinead

doi:10.1097/olq.0000000000000979

Cited by 13 publications

(10 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The incidence rate of anal HPV infection was 16.0 cases/ 100 person-years among those without HPV at baseline, and was 26.8 cases/100 person-years for getting any new HPV genotype among all participants, showing that HPV incidence was high in men with HIV. The incidence rate in our study was similar to a cohort study in America (21.3 cases/100 person-years) [14], higher than a South African study (2.9 cases/100 person-years) [15], and lower than a South-East Asian study (34.1 cases/100 person-years) [8]. We also found that the incidence rate among HIV-positive homosexual men in this study was lower than that of MSM in Guangdong, China (29.6 vs. 37.6 cases/100 person-years) [16], which had a younger study population.…”

Section: Discussionsupporting

confidence: 87%

Incidence, clearance, and factors associated with anal human papilloma virus infection among men with HIV

Zhang,

Sun,

Chen

et al. 2023

Aids

View full text Add to dashboard Cite

Objectives: This study aims to estimate the incidence and persistence/clearance of anal HPV infection and related factors among men with HIV in Taizhou, China. Design: A prospective cohort study Methods: Men with HIV were recruited and followed up from 2016 to 2021. Questionnaire surveys were used to collect social-demographic and behavioral characteristics, and anal swabs were collected for HPV Genotyping. Results: A total of 675 men with HIV were recruited and followed up. After an average follow-up time of 1.75 years, HPV39 (3.8/100 person-years), HPV52 (3.6/100 person-years), HPV51 (3.1/100 person-years), HPV58 (2.5/100 person-years) and HPV16 (2.4 cases/100 person-years) in the high-risk types showed the highest incidence rate. In marriage with woman (aHR = 0.44, 95% CI: 0.20–0.99) showed an inverse association with HPV incidence, while bisexuality or undetermined sexual orientation (aHR = 2.62, 95% CI: 1.08–6.36) showed a positive association. For those infected at baseline, the top three high-risk HPV with the lowest clearance density were HPV52 (32.2/100 person-years), HPV58 (38.1/100 person-years), and HPV16 (43.5/100 person-years). Daily consumption of 1–28 grams alcohol (aHR = 0.62, 95% CI: 0.41∼0.95) showed an inverse association with HPV clearance, while illicit drug use (aHR = 3.24, 95% CI: 1.59∼6.59) showed a positive association. Conclusions: Anal HPV infection and clearance were both active in men with HIV in China. Marriage status and sexuality were associated with the incidence of HPV infection, while substance use including alcohol and illicit drug were associated with HPV clearance. More studies are needed to explore the risk factors of HPV persistence.

show abstract

Section: Discussionsupporting

confidence: 87%

Incidence, clearance, and factors associated with anal human papilloma virus infection among men with HIV

Zhang,

Sun,

Chen

et al. 2023

Aids

View full text Add to dashboard Cite

show abstract

“…The appearance of CW is, therefore, the result of viral multiplication persistence but remains transient until 1–2 dozen months ( 34 , 36 , 39 ). This viral persistence rate and therefore the relative risk of CW occurrence is proportional to age [66% in children and 92% in adults ( 40 )], as children are either not exposed or are less exposed than adults to viral persistence risks, including any sexual practices, smoking, use of hormonal contraceptives, and other infections ( 41 – 44 ).…”

Section: Epidemiology Of Hpv Infection and Related Diseasesmentioning

confidence: 99%

“…Regionally, SSA appears to have slightly higher AGW incidence and prevalence rates ( 60 ), especially among people with multi-sexual partners and those who are immunocompromised ( 41 – 44 ). In developed regions, the incidence of AGW incidence appears low (around 1.5% in the USA) and seems to decrease because of vaccine implementation ( 49 ).…”

Section: Epidemiology Of Hpv Infection and Related Diseasesmentioning

confidence: 99%

Epidemiology and Burden of Human Papillomavirus and Related Diseases, Molecular Pathogenesis, and Vaccine Evaluation

Kombe

Zahid

et al. 2021

Front. Public Health

350

276

View full text Add to dashboard Cite

Diagnosed in more than 90% of cervical cancers, the fourth deadliest cancer in women, human papillomavirus (HPV) is currently the most common pathogen responsible for female cancers. Moreover, HPV infection is associated with many other diseases, including cutaneous and anogenital warts, and genital and upper aerodigestive tract cancers. The incidence and prevalence of these pathologies vary considerably depending on factors including HPV genotype, regional conditions, the study population, and the anatomical site sampled. Recently, features of the cervicovaginal microbiota are found to be associated with the incidence of HPV-related diseases, presenting a novel approach to identify high-risk women through both blood and cervical samples. Overall, the HPV repartition data show that HPV infection and related diseases are more prevalent in developing countries. Moreover, the available (2-, 4-, and 9-valent) vaccines based on virus-like particles, despite their proven effectiveness and safety, present some limitations in terms of system development cost, transport cold chain, and oncogenic HPV variants. In addition, vaccination programs face some challenges, leading to a considerable burden of HPV infection and related diseases. Therefore, even though the new (9-valent) vaccine seems promising, next-generation vaccines as well as awareness programs associated with HPV vaccination and budget reinforcements for immunization are needed.

show abstract

“…To our knowledge, there are no other data on the effect of mental health parameters on response to AGW treatment. As far as other parameters are concerned, AGW clearance has been associated with high vs low CD4+ count in men living with human immunodeficiency virus, 25 while increased recurrence rates of AGW have been associated with smoking. 26 Cryotherapy is one of the most commonly used provideradministered treatments for AGW because it is simple, inexpensive and safe.…”

Section: Discussionmentioning

confidence: 99%

The effect of anxiety, psychopathological symptoms and personality traits on response to treatment in male patients with anogenital warts: a prospective study

Tyros

Papageorgiou

Κανελλέας

et al. 2021

Acad Dermatol Venereol

View full text Add to dashboard Cite

Background In the era of precision medicine, identification of possible predictive factors of clinical response to treatment is fundamental. This need is particularly strong for anogenital warts (AGW), because there are several treatment modalities with different clearance and recurrence rates. However, data regarding the effect of mental health parameters on response to treatment in patients with AGW are lacking. Objectives The purpose of the present study was to evaluate the association between patients’ mental health parameters and AGW treatment outcomes. Methods This was a single‐centre, prospective study that included newly diagnosed male patients with AGW. At their initial visit, all patients completed the State‐Trait Anxiety Inventory (STAI), the Symptom Checklist‐90‐Revised (SCL‐90‐R) and the Eysenck Personality Questionnaire (EPQ) questionnaires, which evaluate anxiety, psychopathological manifestations and personality traits, respectively. All patients received cryotherapy until clearance of lesions and were followed up for 18 months for detection of recurrences. Results The study included 167 male patients. The mean number of days for AGW clearance was 89 ± 65. During the 18‐month follow‐up, 28% of participants showed a recurrence, after a mean number of 150 ± 132 days. No statistically significant association was detected between questionnaires scores and (a) time needed for AGW clearance, (b) time until 1st recurrence and (c) number of recurrences. Conclusion If confirmed, our findings indicate that we may not need to modify our AGW treatment plan according to a patient’s mental health profile.

show abstract

Incidence, Persistence, Clearance, and Correlates of Genital Human Papillomavirus Infection and Anogenital Warts in a Cohort of Men Living With Human Immunodeficiency Virus in South Africa

Cited by 13 publications

References 30 publications

Incidence, clearance, and factors associated with anal human papilloma virus infection among men with HIV

Incidence, clearance, and factors associated with anal human papilloma virus infection among men with HIV

Epidemiology and Burden of Human Papillomavirus and Related Diseases, Molecular Pathogenesis, and Vaccine Evaluation

The effect of anxiety, psychopathological symptoms and personality traits on response to treatment in male patients with anogenital warts: a prospective study

Contact Info

Product

Resources

About