Incidence trends and survival outcomes of penile squamous cell carcinoma: evidence from the Surveillance, Epidemiology and End Results population-based data

Qi, Feng; Wei, Xiao‐Hong; Zheng, Yuxiao; Ren, Xiaohan; Li, Xiao; Zhao, Erkang

doi:10.21037/atm-20-1802

Cited by 14 publications

(5 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There were relatively few studies focusing on the trend of penile cancer mortality. A retrospective study, whose data were from the Netherlands during 1989-2006, suggested a slight decrease in mortality (11,29). Similarly, a decrease in mortality was also observed in England for 1979-2009 (30).…”

Section: Discussionmentioning

confidence: 94%

See 1 more Smart Citation

Trends in Incidence, Mortality, and Survival of Penile Cancer in the United States: A Population-Based Study

et al. 2022

View full text Add to dashboard Cite

PurposeThe aim of this study is to investigate the trends in incidence and mortality, and explore any change in survival of penile cancer in the United States.MethodsWe obtained data from the Surveillance, Epidemiology, and End Results (SEER) database (2000–2018) utilizing the SEER Stat software. The joinpoint regression was used to analyze the secular trend of incidence and incidence-based mortality (IBM) stratified by age, race, and summary stage. The 5-year relative survival rate was also calculated.ResultThe age-adjusted rates of penile cancer patients were 0.38 (0.37–0.39) and 0.21 (0.2–0.21) for overall incidence and IBM, respectively. The 5-year relative survival rates were 67.7%, 66.99%, and 65.67% for the calendar periods of 2000–2004, 2005–2009, and 2010–2014, respectively. No significant changes in incidence by era were observed from 2000 to 2018 [annual percentage change (APC) = 0.5%, p = 0.064]. The IBM rate of penile cancer showed an initial significant increase from 2000 to 2002 (APC = 78.6%, 95% CI, −1.7–224.6) followed by a deceleration rate of 4.6% (95% CI, 3.9–5.3) during 2002 to 2018. No significant improvement in 5-year relative survival was observed. The trends by age, race, and summary stage in incidence and IBM were significantly different.ConclusionThis study, using population-level data from the SEER database, showed an increasing trend in IBM and no significant improvement in the 5-year relative survival rate. Meanwhile, the incidence of penile cancer exhibited a relatively stable trend during the study period. These results might be due to the lack of significant progress in the treatment and management of penile cancer patients in the United States in recent decades. More efforts, like increasing awareness among the general population and doctors, and centralized management, might be needed in the future to improve the survival of this rare disease.

show abstract

Section: Discussionmentioning

confidence: 94%

“…Another possible explanation for this result was that the main population of penile cancer patients was aging. For example, previous studies showed that the most common age of penile cancer patients was between 50 and 70 years (29,39). However, patients aged 75+ years were the main population age group in our study.…”

Section: Discussionmentioning

confidence: 99%

Trends in Incidence, Mortality, and Survival of Penile Cancer in the United States: A Population-Based Study

et al. 2022

View full text Add to dashboard Cite

show abstract

“…6,7 American data assessed using the Survival, Epidemiology and End Results (SEER) program has demonstrated similar or lesser values for the occurrence of penile cancer with suggestions of multifactorial increases in incidence over time. 15,16 Canadian Cancer Statistics data from 2018 indicated an overall incidence rate of approximately 1.05/100,000 when calculated from the Statistics Canada male population at this time. 13 These reports are consistent with current epidemiological interpretations of lower incidence amongst developed nations.…”

Section: Discussionmentioning

confidence: 94%

A population-based analysis of the epidemiology of penile cancer in Newfoundland and Labrador

Janes,

Johnston

2023

CUAJ

View full text Add to dashboard Cite

Introduction: Penile cancers are a rare subset of carcinomas accounting for <1% of all diagnosed malignancies. There have been recent reports of increasing incidence globally; however, there is limited Canadian literature pertaining to these neoplasms. The province of Newfoundland and Labrador (NL) represents an important entity to study, possessing the highest national incidence of cancer, along with a plethora of relevant risk factors for penile cancer. Methods: A retrospective chart analysis of all patients with a diagnosis of penile cancer in NL between the years of 2006 and 2018 was conducted. The main outcomes included overall incidence, proportion with metastatic disease, tumor demographics, and overall survival (OS). Incidence among the male population was calculated using Statistics Canada annual reports. Results: An identified 81 cases satisfied the inclusion criteria, with a median age at diagnosis of 65 (interquartile range 20) years. Crude incidence of penile cancer ranged from 1.20 to 4.27/100 000 males in 2007 and 2010, respectively, while the average age-standardized incidence was 2.34/100 000 males across the study timeframe. Metastatic disease was noted in 17 (21.0%) patients, with a five-year OS of 74% for all penile malignancies, decreasing to 66% in those with invasive squamous cell carcinoma. Conclusions: The incidence of penile cancer in our population was higher than reported Western jurisdictions and showed frequent rates of metastatic spread. These observations are likely multifactorial, resultant of chronic inflammation paired with high rates of modifiable risk factors and diagnostic delays. An evident need for greater examination and improved reporting of these malignancies in the province was identified.

show abstract

“…Tumour grade has been shown to be an independent prognostic indictor for penile squamous cell carcinoma, with a higher grade tumour associated with a poorer prognosis. 13 The impact of p16 status on survival outcomes Current evidence suggests that HPV infection in penile cancer carries a better 5-year recurrence-free survival and overall survival than patients who are HPV negative. 12 14 15 HPV infection is also associated with improved loco-regional control of penile squamous cell carcinoma.…”

Section: Hpv Prevalence In An Irish Penile Cancer Cohortmentioning

confidence: 99%

The relationship of human papillomavirus positivity with tumor characteristics in an Irish penile cancer population

Browne

Foley

O'Kelly

et al. 2022

CUAJ

View full text Add to dashboard Cite

Introduction: Penile cancer is a rare malignancy, with a European-wide annual incidence rate of 1/100 000 males. Approximately one-third of cases are attributable to human papillomavirus (HPV) infection. p16INK4a is a recognized surrogate marker for HPV infection in penile cancer. University Hospital Waterford (UHW) is the national referral center for penile cancer in Ireland. We report the prevalence of HPV infection and histological characteristics of an Irish penile cancer cohort using p16INK4a as a surrogate marker. Methods: Patients who attended UHW for penile cancer surgery between June 2015 and November 2020 were entered into a prospectively maintained database. Clinical, histopathological, and outcome data were collected. Results: Over the study period, 70 patients with a histological diagnosis of penile squamous cell carcinoma had staining for p16INK4a, of whom 64% were positive. p16INK4a positive patients were significantly younger at diagnosis, with a mean age of 61±15 years compared to 68±12 (p <0.05). Of note, 97% of tumors with high-risk histology were p16INK4a positive (p<0.001). p16INK4a positivity was more prevalent among higher-grade tumors (p<0.02). Interestingly, p16INK4a status was not associated with recurrence-free or overall survival. Conclusions: Our data is representative of the Irish landscape in penile cancer over the last five years. Using p16INK4a staining, we demonstrate a high rate of HPV prevalence in penile cancer cases in our patient cohort, which is associated with prognostically worse tumor subtypes. This would suggest that HPV vaccination of adolescent boys is a useful public health intervention in preventing penile cancer in the Irish male population.

show abstract

Incidence trends and survival outcomes of penile squamous cell carcinoma: evidence from the Surveillance, Epidemiology and End Results population-based data

Cited by 14 publications

References 23 publications

Trends in Incidence, Mortality, and Survival of Penile Cancer in the United States: A Population-Based Study

Trends in Incidence, Mortality, and Survival of Penile Cancer in the United States: A Population-Based Study

A population-based analysis of the epidemiology of penile cancer in Newfoundland and Labrador

The relationship of human papillomavirus positivity with tumor characteristics in an Irish penile cancer population

Contact Info

Product

Resources

About