Incidencia de bacterias multi-resistentes en unidades de cuidados intensivos de hospitales chilenos

Acuña, Mauricio; Cifuentes, Marcela; Silva, Francisco; Rojas, Álvaro; Cerda, Jaime; Labarca, Jaime

doi:10.4067/s0716-10182017000600570

Cited by 3 publications

(1 citation statement)

References 8 publications

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“…La propagación mundial de las ERC es una amenaza importante para las poblaciones de pacientes vulnerables en todo el mundo. 6 En Chile, un estudio realizado por el Grupo Colaborativo de Resistencia Bacteriana, sobre incidencia de bacterias multi-resistentes en 20 unidades de cuidado intensivo de adulto en el período enero de 2014-octubre de 2015, informó que la incidencia de ERC, alcanzó una mediana de 1,77, pero la incidencia fue variable con un intervalo entre 0,0 y 8,68 x 1.000 pacientes-día 7 .…”

Section: Antimicrobianosunclassified

Costo-efectividad de ceftazidima/avibactam versus colistin + meropenem en el tratamiento de infecciones por enterobacterias resistentes a carbapenémicos en Chile

A¹,

Fandiño²

2021

Rev. chil. infectol.

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Section: Antimicrobianosunclassified

Costo-efectividad de ceftazidima/avibactam versus colistin + meropenem en el tratamiento de infecciones por enterobacterias resistentes a carbapenémicos en Chile

A¹,

Fandiño²

2021

Rev. chil. infectol.

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Nosocomial Acinetobacter baumannii infection in children in adult versus pediatric intensive care units

Kim

Yoon

2020

Pediatrics International

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Background: We hypothesized that children treated in adult intensive care units (ICUs) might be at increased risk of hospital-acquired infection. We therefore compared the incidence of Acinetobacter baumannii infection in children treated in pediatric ICUs (PICUs) and in those treated in adult ICUs. Methods: Patients aged <18 years admitted to PICUs or adult ICUs between March 2009 and June 2017 were enrolled. We retrospectively investigated A. baumannii isolates and calculated the A. baumannii incidence during ICU admission. Cox regression was used to identify possible risk factors for A. baumannii infection. Results: Eight hundred and thirty ICU cases were included; 508 were treated in PICUs ("PICU group") and 322 in adult ICUs ("adult-ICU group"). Acinetobacter baumannii was isolated 19 (3.7%) and 23 (7.1%) times in the PICU and adult-ICU groups, respectively. Incidence densities for A. baumannii acquisition in PICU and adult-ICU groups were 1.63 and 5.62 per 1,000 ICU days, respectively. In the Cox regression model, the hazard ratio for A. baumannii acquisition associated with treatment in PICUs was 0.33 (95% confidence interval: 0.17-0.61; P = 0.001). In multivariate analysis after adjusting for age and sex, treatment in PICU remained significantly associated with a reduced risk of A. baumannii infection (hazard ratio: 0.40; 95%; confidence interval: 0.20-0.76). Conclusions: Pediatric patients treated in a PICU had a lower rate and incidence density of A. baumannii nosocomial infection than those treated in adult ICUs, suggesting that PICUs provide better infection control for children than adult ICUs.

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Bacterial Resistance in Hospital-Acquired Infections Acquired in the Intensive Care Unit: A Systematic Review

Loaiza

Ruiz

Patiño

et al. 2023

Acta Med. (Hradec Kralove, Czech Repub.)

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Purpose: In this review we present the status of the prevalence of bacteria resistant to antibiotics and the main antibiotic resistance genes that are reported in infections acquired in intensive care units (ICU) around the world. Methods: A systematic review based on the PRISMA guide was carried out, from the Science Direct, Redalyc, Scopus, Hinari, Scielo, Dialnet, PLOS, ProQuest, Taylor, Lilacs and PubMed/Medline databases. Inclusion criteria of this review were original research study published in a scientific journal in a 10-year time span from 1 January 2017 and 30 April 2022. Results: A total of 1686 studies were identified, but only 114 studies were considered eligible for inclusion. Klebsiella pneumoniae and Escherichia coli resistant to carbapenems and producers of extended-spectrum β-lactamases (ESBL) are the most frequently isolated pathogens in ICUs in Asia, Africa and Latin America. The blaOXA and blaCTX were antibiotic resistance genes (ARG) most commonly reported in different geographic regions (in 30 and 28 studies, respectively). Moreover, multidrug-resistant (MDR) strains were reported in higher frequency in hospital-acquired infections. Reports of MDR strains vary between continents, with the majority of publications being in Asia and between countries, with Egypt and Iran being highlighted. There is a predominance of few bacterial clones with MDR phenotype, for example, clonal complex 5 Methicillin-Resistant Staphylococcus aureus (CC5-MRSA) circulates frequently in hospitals in the United States, clone ST23-K. pneumoniae is reported in India and Iran, and clone ST260 carbapenemase-producing P. aeruginosa in the United States and Estonia. Conclusion: Our systematic review reveals that ESBL- and carbapenemase-producing K. pneumoniae and E. coli are the most problematic bacteria that are reported, mainly in tertiary hospitals in Asia, Africa, and Latin America. We have also found propagation of dominant clones with a high degree of MDR, becoming a problem due to its high capacity to cause morbidity, mortality and additional hospital costs.

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Incidencia de bacterias multi-resistentes en unidades de cuidados intensivos de hospitales chilenos

Cited by 3 publications

References 8 publications

Costo-efectividad de ceftazidima/avibactam versus colistin + meropenem en el tratamiento de infecciones por enterobacterias resistentes a carbapenémicos en Chile

Costo-efectividad de ceftazidima/avibactam versus colistin + meropenem en el tratamiento de infecciones por enterobacterias resistentes a carbapenémicos en Chile

Nosocomial Acinetobacter baumannii infection in children in adult versus pediatric intensive care units

Bacterial Resistance in Hospital-Acquired Infections Acquired in the Intensive Care Unit: A Systematic Review

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