Incidencia y mortalidad del cáncer cutáneo en España: revisión sistemática y metaanálisis

Tejera‐Vaquerizo, Antonio; Descalzo, Miguel Ángel; Otero-Rivas, M.M.; Posada-García, C; Rodríguez-Pazos, L.; Pastushenko, Ievgenia; Marcos‐Gragera, Rafael; García‐Doval, I.

doi:10.1016/j.ad.2015.12.008

Cited by 147 publications

(23 citation statements)

References 26 publications

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“…Between September 2014 and June 2015, two hundred and ten primary and secondary public school teachers were selected by convenience. Ten teachers were excluded from the study for the following reasons: incomplete surveys and ineligibility . Finally, 200 participants were recruited by convenience: 100 PET and 100 non‐PET matching for age and for gender (using three age groups: 30–39 years, N = 40 PET (12 women) and N = 40 non‐PET (12 women); 40–49 years, N = 38 PET (12 women) and N = 38 non‐PET (12 women); 50–60 years, N = 22 PET (three women) and N = 22 non‐PET (three women)).…”

Section: Resultsmentioning

confidence: 99%

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Sun Protection Habits and Sun Exposure of Physical Education Teachers in the South of Spain

Castro‐Maqueda

Manzanedo

Fernández-Santos

et al. 2019

Photochem & Photobiology

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The high prevalence and increasing incidence of skin cancer (SC) is a significant public health problem. We can address its main risk factor, which is incident and accumulated solar radiation, and its damages by disseminating knowledge and promoting changes in habits and attitudes toward the sun. The influence of teachers in the education of young people is crucial. Physical education teachers (PET) spend the majority of their time outdoors, thereby exposing themselves to solar radiation daily and greatly increasing the risk of SC. We carried out a case–control study matching for age and gender through surveys about photoexposure and photoprotection habits on a sample of 200 teachers (100 PET and 100 non‐PET) on South of Spain. The results confirmed that there is a significant difference in sun exposure during the workday; PET group showed higher exposure (P < 0.01). We ascertained that photoprotection habits are deficient across the population. These data contribute to the understanding of the danger associated with poor sun protection among teachers (primary and secondary school teachers) and its mitigation. It is also worth noting that future prevention campaigns will be necessary for the subsequent correct transmission of the habits to students.

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Section: Resultsmentioning

confidence: 99%

“…For this reason, it is estimated that the SC mortality rate in Mediterranean countries will increase by 80–100% over the next 15 years . The incidence rate of basal cell carcinoma, the most common of all SCs, has reached 253.23/100 000 persons per year in Spain .…”

Section: Introductionmentioning

confidence: 99%

Sun Protection Habits and Sun Exposure of Physical Education Teachers in the South of Spain

Castro‐Maqueda

Manzanedo

Fernández-Santos

et al. 2019

Photochem & Photobiology

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“…Although the incidence of non-melanotic skin cancers (NMSCs) is not typically counted in cancer registries, the Girona (Spain) Cancer registry has collected data on all non-melanoma skin cancers since 1994. In this database, the incidence rate of basal cell carcinoma was 113 per 100 000 PY, squamous cell carcinoma was 38, melanoma 8.76 and MCC was 0.28 per 100 000 PY [73].…”

Section: (D) How Rare Is Merkel Cell Carcinoma?mentioning

confidence: 98%

Merkel cell polyomavirus and Merkel cell carcinoma

DeCaprio

2017

Phil. Trans. R. Soc. B

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Merkel cell polyomavirus (MCPyV) causes the highly aggressive and relatively rare skin cancer known as Merkel cell carcinoma (MCC). MCPyV also causes a lifelong yet relatively innocuous infection and is one of 14 distinct human polyomaviruses species. Although polyomaviruses typically do not cause illness in healthy individuals, several can cause catastrophic diseases in immunocompromised hosts. MCPyV is the only polyomavirus clearly associated with human cancer. How MCPyV causes MCC and what oncogenic events must transpire to enable this virus to cause MCC is the focus of this essay.This article is part of the themed issue 'Human oncogenic viruses'.

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“…Despite these promising results, a part of patients develops pharmacological resistance significantly reducing the effectiveness to these treatments ( Sandri et al, 2016 ; Kalal et al, 2017 ). Several studies showed a very high mortality rate for cutaneous melanoma ranging from 2.17 to 2.7 per 100,000 persons ( McCourt et al, 2014 ; Tejera-Vaquerizo et al, 2016 ; Brunssen et al, 2017 ). This high mortality rate is mainly linked to the aggressiveness of cutaneous melanomas ( Mathieu et al, 2012 ), to the development of drug resistance ( Lim et al, 2017 ) and to their high invasive and metastatic powers ( Aladowicz et al, 2013 ).…”

Section: Introductionmentioning

confidence: 99%

MMP-9 as a Candidate Marker of Response to BRAF Inhibitors in Melanoma Patients With BRAFV600E Mutation Detected in Circulating-Free DNA

et al. 2018

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The BRAFV600E mutation is associated with melanoma development and its detection in circulating-free DNA cannot be observed in all melanoma patients harboring this mutation in tumor specimens. Beside the circulating-free DNA BRAFV600E mutation, other markers of therapeutic response should be identified. Matrix metalloproteinase-9 (MMP-9) could be one of them as its role as indicator of invasiveness in melanoma have been explored. In this study, MMP-9 was evaluated in melanoma cells after treatment with dabrafenib. In vitro data were validated in 26 melanoma patients, of which 14 treated with BRAF inhibitor alone and 12 treated with both BRAF and MEK inhibitors, by ELISA assay and droplet digital PCR for measuring MMP-9 serum levels and circulating-free DNA BRAFV600E mutation, respectively. Statistical analyses were performed to evaluate the prognostic significance of MMP-9, progression-free survival (PFS) and overall survival (OS) according to the BRAFV600E mutation and MMP-9 levels. The performed analyses showed that MMP-9 and pEKR1-2 were statistically down-regulated in melanoma cells after treatment with dabrafenib. Circulating-free DNA BRAFV600E mutation was detected in 11 out of 26 melanoma patients showing higher levels of MMP-9 compared to those with undetectable BRAFV600E mutation. Furthermore, higher levels of MMP-9 and circulating-free DNA BRAFV600E mutation were associated with lower PFS and OS. Finally, the monitoring of therapy showed that MMP-9 significantly decreased at T1 and T2, but not at T-last, for the patients with detectable circulating-free DNA BRAFV600E mutation. In conclusion, high levels of MMP-9 and circulating-free DNA BRAFV600E mutation are associated with poor PFS and OS. MMP-9 may represent a promising indicator of response to BRAF inhibitors in combination with the detection of BRAFV600E mutation.

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Incidencia y mortalidad del cáncer cutáneo en España: revisión sistemática y metaanálisis

Cited by 147 publications

References 26 publications

Sun Protection Habits and Sun Exposure of Physical Education Teachers in the South of Spain

Sun Protection Habits and Sun Exposure of Physical Education Teachers in the South of Spain

Merkel cell polyomavirus and Merkel cell carcinoma

MMP-9 as a Candidate Marker of Response to BRAF Inhibitors in Melanoma Patients With BRAFV600E Mutation Detected in Circulating-Free DNA

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