Incidental dedifferentiated mediastinal liposarcoma on F-18-fluciclovine PET/CT

Boatright, Christine; Walker, Christopher M.; Donald, J.; Cui, Wei; Nagji, Alykhan S.

doi:10.1016/j.clinimag.2019.08.004

Cited by 5 publications

(5 citation statements)

References 23 publications

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“…4 Puede complementarse con resonancia magnética del tórax, angiotomografía, eventualmente PET scan para la caracterización del tumor y la extensión de enfermedad. 5 El diagnóstico histológico mediante biopsia percutánea con aguja cortante es ideal para el estudio anatomopatológico, inmunohistoquímica y biomarcadores, de ser necesario. La participación del comité de tumores es trascendental para recomendaciones del manejo oncológico del paciente.…”

Section: Discussionunclassified

Liposarcoma gigante mediastinal. Cirugía radical con abordaje Clamshell y manejo en la Unidad de Cuidados Críticos

Amorin,

Guillen Zeballos,

Quispe Soto

et al. 2024

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Section: Discussionunclassified

Liposarcoma gigante mediastinal. Cirugía radical con abordaje Clamshell y manejo en la Unidad de Cuidados Críticos

Amorin,

Guillen Zeballos,

Quispe Soto

et al. 2024

Respirar

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“…In the study cohort, all tested DDL tumors (16/16, 100%) exhibited MDM2 amplification. However, only 11 of 52 (21.1%) historical cases were subjected to FISH analysis, and all of them displayed positive results (10,18,40,(42)(43)(44)(45)(46)(47). We endorsed ancillary tests for cases in rare locations, such as the mediastinum, lung and/or ambiguous morphology.…”

Section: Discussionmentioning

confidence: 99%

“…It should be mentioned that IMT-like features are a recently described histologic pattern of DDL, while none of the intrathoracic cases have been described in the English literature ( 37 – 39 ). In the 52 reported DDLs, 10 of them (10/52, 19.2%) exhibited low-grade dedifferentiation ( 9 , 10 , 12 , 40 – 42 ). Notably, 1 case was DDL with leiomyosarcomatous differentiation, mimicking smooth muscle tumor and pulmonary adenofibroma histologically.…”

Section: Discussionmentioning

confidence: 99%

Primary intrathoracic liposarcomas: A clinicopathologic and molecular study of 43 cases in one of the largest medical centers of China

Xie

Jing²,

Zhao³

et al. 2022

Front. Oncol.

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IntroductionPrimary intrathoracic liposarcoma is extremely rare, and most published series lack genetic analyses. The aim of our study is to better understand the clinicopathologic and genetic features of these rare lesions.Materials and methodsForty-three primary intrathoracic liposarcomas were identified and most cases were analyzed by systematic genetic studies, including fluorescence in situ hybridization (FISH), whole-exome sequencing (WES), and Sanger sequencing.ResultsThis series included 27 males and 16 females (ratios, 1.68:1) aged 24-73 years (median, 53 years). Tumors mainly occurred in the mediastinum (n=23, 53.5%), followed by pleural cavity (n=16, 37.2%) and lung (n=4, 9.3%). The study included 21 well-differentiated liposarcomas (WDLs), 19 dedifferentiated liposarcomas (DDLs), 2 myxoid pleomorphic liposarcomas (MPLs) and 1 pleomorphic liposarcoma (PL), without identification of myxoid liposarcoma. FISH analysis identified MDM2 amplification in 17 of 18 WDLs (94.4%) and all DDLs (16/16, 100.0%). The MDM2-nonamplified WDL was CDK4-nonamplified but FRS2-amplified. WES and Sanger sequencing found somatic TP53 mutation in the 2 MPLs. Follow-up information was available for 33 of 38 cases (86.8%). Thirteen patients (39.4%) showed no evidence of disease, 10 patients (30.3%) were alive with disease, and 8 patients (24.2%) died of disease. Fourteen cases developed recurrence and 1 with metastasis.ConclusionsWDL/DDL was the overwhelming subtype in this location, followed by MPL and PL. Analysis of the FRS2 gene, in combination with MDM2 and other genes of 12q13-15, may more precisely characterize WDL/DDLs. MPL is the most fatal subtype of this site. Further studies are needed to explore the role of TP53 in the pathogenesis of MPL.

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“…Hence, the tumor was best classified as type AB (type B2 for the B component) with coexisting type B3. Because its approval for detection of recurrent prostate cancer, 18 F-fluciclovine has demonstrated focal uptake in many nonprostatic neoplasms among various organ systems 1–8 . Uptake can also occur in benign infectious and inflammatory processes, such as prostatic hyperplasia, osteoid osteomas, and acute appendicitis 9–12 .…”

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confidence: 99%

“…Because its approval for detection of recurrent prostate cancer, 18 F-fluciclovine has demonstrated focal uptake in many nonprostatic neoplasms among various organ systems. [1][2][3][4][5][6][7][8] Uptake can also occur in benign infectious and inflammatory processes, such as prostatic hyperplasia, osteoid osteomas, and acute appendicitis. 9-12 A recent report by Robertson et al 13 presents a case of 18 F-fluciclovine uptake in a thymoma, and Fallanca et al 14 present a thymoma picked up incidentally on 11 C-choline PET/CT.…”

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confidence: 99%

Incidental Uptake of 18F-Fluciclovine by Type AB Thymoma

Somnay

Dalal

2022

Clin Nucl Med

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Biochemical recurrence of prostate cancer, detected by a rising PSA, may reflect intraprostatic or extraprostatic recurrence. 18 F-Fluciclovine (Axumin), a synthetic amino acid substrate in tumor metabolism, has frequently been used for to localize recurrent prostate cancers. We present a 71-year-old man with biochemical recurrence of prostate cancer but no convincing imaging findings on 18 F-fluciclovine PET/CT. Of note, however, was an incidental uptake within the anterior mediastinum, which was found on biopsy to be a type AB thymoma. With this, we stress that awareness of false-positive uptake patterns is crucial for accurate diagnosis of recurrent prostate cancer.

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Incidental dedifferentiated mediastinal liposarcoma on F-18-fluciclovine PET/CT

Cited by 5 publications

References 23 publications

Liposarcoma gigante mediastinal. Cirugía radical con abordaje Clamshell y manejo en la Unidad de Cuidados Críticos

Liposarcoma gigante mediastinal. Cirugía radical con abordaje Clamshell y manejo en la Unidad de Cuidados Críticos

Primary intrathoracic liposarcomas: A clinicopathologic and molecular study of 43 cases in one of the largest medical centers of China

Incidental Uptake of 18F-Fluciclovine by Type AB Thymoma

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