Incidental Gall Bladder Carcinoma in Laparoscopic Cholecystectomy: A Report of 6 Cases and a Review of the Literature

Jetley, Sujata; Sabina, K; H, Mj; Zs, Jairajpuri

doi:10.7860/jcdr/2012/5001.2677

Cited by 28 publications

(47 citation statements)

References 15 publications

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“…In the present study, although the disease was more commonly detected in females, however the male: female ratio was comparatively higher (0.52) than other Indian studies by Sujata and Amanullah et al [8,12]. The mean age of incidental carcinoma detection in our study was 57.8 years, however, in other studies from various parts of world including Saudi, Japan, China and Italy the mean age of presentation is higher than 65 years [7,11,13,14].…”

Section: Discussioncontrasting

confidence: 76%

Incidental Detection of Carcinoma Gall Bladder in Laparoscopic Cholecystectomy Specimens: A Thirteen Year Study of 23 Cases and Literature Review

Gulwani

Gupta

Kaur

2015

Indian J Surg Oncol

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Carcinoma of gall bladder is the most common malignancy of the biliary tract worldwide and is usually associated with poor prognosis. In this era of laparoscopic cholecystectomy, there has been increase in detection of early stage incidental gall bladder carcinoma in cholecystectomy specimens. A retrospective study was carried out in tertiary care hospital in central India. A total of 2990 patients underwent laparoscopic cholecystectomy during the year 2001-2013. Hospital records and histopathology reports of these patients were studied in detail. Twenty three cases of gall bladder carcinoma were detected incidentally accounting for an incidence of 0.76 %. It was more common in females with an M: F ratio of 1:1.9. Mean age of presentation was 57.8 years. Gall stones were present in 22 cases and one patient presented with features of acute cholecystitis. Three patients had associated xanthogranulomatous inflammation and 10 had associated intestinal metaplasia. It is not uncommon to encounter incidental malignancies of gall bladder in laparoscopic cholecystectomy specimens sent to histopathology for presumably benign disease. Histopathology reports must include comments on extent of infiltration, perineural invasion, tumor differentiation and nodal involvement for oncologist information and subsequent management of patients.

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Section: Discussioncontrasting

confidence: 76%

Incidental Detection of Carcinoma Gall Bladder in Laparoscopic Cholecystectomy Specimens: A Thirteen Year Study of 23 Cases and Literature Review

Gulwani

Gupta

Kaur

2015

Indian J Surg Oncol

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“…A possible relationship has been assessed, and focuses mainly on the longstanding chronic inflammation caused by gallstones. 18 In the present study, three of four UPGC cases had chronic cholecystitis. However, we could not undertake further analyses because of the small number of cancer cases.…”

mentioning

confidence: 99%

Incidental findings during routine pathological evaluation of gallbladder specimens: review of 1,747 elective laparoscopic cholecystectomy cases

Başak

Hasbahçeci

Canbak

et al. 2016

annals

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INTRODUCTION Cholecystectomy for benign gallbladder diseases can lead to previously undiagnosed gallbladder cancer during histopathological evaluation. Despite some controversy over its usefulness, histopathological evaluation of all gallbladder specimens is common in most hospitals. We evaluated the results of routine pathology of the gallbladder after cholecystectomy for benign gallbladder diseases with regard to unexpected primary gallbladder cancer (UPGC). METHODS Patients undergoing cholecystectomy because of benign gallbladder diseases between 2009 and 2013 were enrolled in this study. All gallbladder specimens were sent to the pathology department, and histopathological reports were examined in detail. The impact of demographic features on pathological diagnoses and prevalence of UPGC assessed. Data on additional interventions and postoperative survival for patients with UPGC were collected. RESULTS We enrolled 1,747 patients (mean age, 48.7±13.6 years). Chronic cholecystitis was the most common diagnosis (96.3%) and was associated significantly with being female (p=0.001). Four patients had UPGC (0.23%); one was stage T3 at the time of surgery, and the remaining three cases were stage T2. CONCLUSIONS Routine histopathological examination of the gallbladder is valuable for identification of cancer that requires further postoperative management.

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“…On macroscopic examination, this entity showed marked thickening of gall bladder. In a study made by Sujata et al [13] to determine spectrum of histopathological lesion in cholecystectomy specimens found 0.5% cases of follicular cholecystitis. In the present study 2 cases (0.2%) of follicular cholecystitis were found.…”

Section: Discussionmentioning

confidence: 99%

Study of Various Histopathological Lesions In Resected Gall Bladder Specimen: A Study In Consecutive 898 Cholecystectomies

Verma

Gupta²

2017

int.jour.sci.res.mana

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The histopathological spectrum of gall bladder is extremely variable depending on sex, race, age, countriesand institutes. There is a wide spectrum of pathologies affecting the gall bladder ranging from congenitalanomalies, calculi and its complications, non inflammatory, inflammatory to the neoplasticlesions.Gallstones are one of the major causes of morbidity and mortality all over the world. Cholelithiasis isvery common particularly in fatty, fertile and female of forty to fifty and affects male and children also . Gallstone may lead to several complications such as cholecystitis, hydrops, mucocele, internal biliary fistulaand carcinoma.Other histological alterations include acute cholecystitis, chronic cholecystitis and its variantssuch as lymphoplasmacytic and sclerosing cholecystitis, follicular cholecystitis, eosinophilic cholecystitisand xanthogranulomatous cholecystitis.Gall bladder carcinoma ranks 6 th in the gastrointestinal malignanttumour and due to non specific clinical presentation it is rarely diagnosed at an early stage . Most of theincidentally detected carcinoma are surgically resectable, with a good survival rate. Though simplecholecystectomy is said to be sufficient in stages T is and T 1a carcinomas, radical resection is stronglyrecommended in stages beyond that. This reflects the importance of histopathological study of allcholecystectomy specimens, irrespective of clinical impression.Cholecystectomy performed with provisionaldiagnosis of benign disease based on clinical, ultrasonological and computerized tomographic scanningmisses a significant numbers of early malignant lesions of gall bladder, as histopathological detection ofcarcinoma is a gold standard and will continue to be superior to clinical and radiological examination

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Incidental Gall Bladder Carcinoma in Laparoscopic Cholecystectomy: A Report of 6 Cases and a Review of the Literature

Cited by 28 publications

References 15 publications

Incidental Detection of Carcinoma Gall Bladder in Laparoscopic Cholecystectomy Specimens: A Thirteen Year Study of 23 Cases and Literature Review

Incidental Detection of Carcinoma Gall Bladder in Laparoscopic Cholecystectomy Specimens: A Thirteen Year Study of 23 Cases and Literature Review

Incidental findings during routine pathological evaluation of gallbladder specimens: review of 1,747 elective laparoscopic cholecystectomy cases

Study of Various Histopathological Lesions In Resected Gall Bladder Specimen: A Study In Consecutive 898 Cholecystectomies

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